scholarly journals Somatic MIWI2 Hinders Direct Lineage Reprogramming From Fibroblast to Hepatocyte

Stem Cells ◽  
2019 ◽  
Vol 37 (6) ◽  
pp. 803-812 ◽  
Author(s):  
Xiaojie Shi ◽  
Zipei Xiao ◽  
Francesco Zonta ◽  
Wei Wang ◽  
Yue Wan ◽  
...  
Keyword(s):  
Lineage Reprogramming

scholarly journals Direct lineage reprogramming of post-mitotic callosal neurons into corticofugal neurons in vivo

2013 ◽  
Vol 15 (2) ◽  
pp. 214-221 ◽  
Author(s):  
Caroline Rouaux ◽  
Paola Arlotta
Keyword(s):  
Lineage Reprogramming

Somatic Lineage Reprogramming

2021 ◽  
pp. a040808
Author(s):  
Hannah Shelby ◽  
Tara Shelby ◽  
Marius Wernig
Keyword(s):  
Lineage Reprogramming

scholarly journals Profiling of the reprogramome and quantification of fibroblast reprogramming to pluripotency

2020 ◽  
Author(s):  
Kejin Hu ◽  
Lara Ianov ◽  
David Crossman
Keyword(s):  
Mathematical Model ◽  
Pluripotent Stem Cells ◽  
Human Fibroblasts ◽  
Ectopic Expression ◽  
Rna Seq ◽  
Cellular Morphogenesis ◽  
Lineage Reprogramming ◽  
Full Complement ◽  
Wnt Pathways ◽  
Cellular Feature

ABSTRACTPluripotent state can be established via reprogramming of somatic nuclei by factors within an oocyte or by ectopic expression of a few transgenes. Considered as being extensive and intensive, the full complement of genes to be reprogrammed, however, has never been defined, nor has the degree of reprogramming been determined quantitatively. Here, we propose a new concept of reprogramome, which is defined as the full complement of genes that need to be reprogrammed to the expression levels found in pluripotent stem cells (PSCs). This concept in combination with RNA-seq enables us to precisely profile reprogramome and sub-reprogramomes, and study the reprogramming process with the help of other available tools such as GO analyses. With reprogramming of human fibroblasts into PSCs as an example, we have defined the full complement of the human fibroblast-to-PSC reprogramome. Furthermore, our analyses of the reprogramome revealed that WNT pathways and genes with roles in cellular morphogenesis have to be extensively and intensely reprogrammed for the establishment of pluripotency. We further developed the first mathematical model to quantitate the overall reprogramming, as well as reprogramming in a specific cellular feature such as WNT signaling pathways and genes regulating cellular morphogenesis. We anticipate that our concept and mathematical model may be applied to study and quantitate other reprogramming (pluripotency reprogramming from other somatic cells, and lineage reprogramming), as well as transcriptional and epigenetic differences between any two types of cells including cancer cells and their normal counterparts.

scholarly journals Advances in cell lineage reprogramming

2013 ◽  
Vol 56 (3) ◽  
pp. 228-233 ◽  
Author(s):  
JunNian Zhou ◽  
Wen Yue ◽  
XueTao Pei
Keyword(s):  
Cell Lineage ◽  
Lineage Reprogramming

scholarly journals A two-step lineage reprogramming strategy to generate functionally competent human hepatocytes from fibroblasts

Cell Research ◽  
2019 ◽  
Vol 29 (9) ◽  
pp. 696-710 ◽  
Author(s):  
Bingqing Xie ◽  
Da Sun ◽  
Yuanyuan Du ◽  
Jun Jia ◽  
Shicheng Sun ◽  
...  
Keyword(s):  
Human Hepatocytes ◽  
Lineage Reprogramming

Direct Lineage Reprogramming: Harnessing Cell Plasticity between Liver and Pancreas

2019 ◽  
Vol 12 (7) ◽  
pp. a035626 ◽  
Author(s):  
Silvia Ruzittu ◽  
David Willnow ◽  
Francesca M. Spagnoli
Keyword(s):  
Cell Plasticity ◽  
Lineage Reprogramming ◽  
Liver And Pancreas

Pluripotent Reprogramming and Lineage Reprogramming: Promises and Challenges in Cardiovascular Regeneration

2014 ◽  
Vol 20 (4) ◽  
pp. 304-313 ◽  
Author(s):  
Wen-Jun He ◽  
Qian Hou ◽  
Qing-Wang Han ◽  
Wei-Dong Han ◽  
Xiao-Bing Fu
Keyword(s):  
Cardiovascular Regeneration ◽  
Lineage Reprogramming

scholarly journals Human Hepatocytes with Drug Metabolic Function Induced from Fibroblasts by Lineage Reprogramming

2014 ◽  
Vol 14 (3) ◽  
pp. 394-403 ◽  
Author(s):  
Yuanyuan Du ◽  
Jinlin Wang ◽  
Jun Jia ◽  
Nan Song ◽  
Chengang Xiang ◽  
...  
Keyword(s):  
Human Hepatocytes ◽  
Metabolic Function ◽  
Lineage Reprogramming
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