scholarly journals In Reply to the Letter to the Editor from Anderson et al.: An Induced Pluripotent Stem Cell Patient Specific Model of Complement Factor H (Y402H) Polymorphism Displays Characteristic Features of Age-Related Macular Degeneration and Indicates a Beneficial

Stem Cells ◽  
2018 ◽  
Vol 36 (4) ◽  
pp. 627-629
Author(s):  
Dean Hallam ◽  
David Rawlings ◽  
David Steel ◽  
Lyle Armstrong ◽  
Majlinda Lako
Keyword(s):  
Induced Pluripotent Stem Cell ◽  
Specific Model ◽  
Factor H ◽  
Age Related Macular Degeneration ◽  
Patient Specific ◽  
Complement Factor ◽  
Age Related ◽  
Characteristic Features ◽  
Induced Pluripotent ◽  
Y402h Polymorphism

Complement factor H Y402H polymorphism and characteristics of exudative age-related macular degeneration lesions

2008 ◽  
Vol 86 (4) ◽  
pp. 390-394 ◽  
Author(s):  
Sanna Seitsonen ◽  
Irma Järvelä ◽  
Seppo Meri ◽  
Petri Tommila ◽  
Päivi Ranta ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Factor H ◽  
Age Related Macular Degeneration ◽  
Complement Factor H ◽  
Complement Factor ◽  
Age Related ◽  
Y402h Polymorphism

scholarly journals Association of complement factor H Y402H polymorphism and age-related macular degeneration in Brazilian patients

2010 ◽  
Vol 88 (5) ◽  
pp. e165-e169 ◽  
Author(s):  
Anderson G. Teixeira ◽  
Aldacilene S. Silva ◽  
Fabio L.H. Lin ◽  
Roberta Velletri ◽  
Lorena Bavia ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Factor H ◽  
Age Related Macular Degeneration ◽  
Complement Factor H ◽  
Complement Factor ◽  
Age Related ◽  
Y402h Polymorphism

scholarly journals Analysis of the association between CFH Y402H polymorphism and response to intravitreal ranibizumab in patients with neovascular age-related macular degeneration (nAMD)

2018 ◽  
Vol 18 (3) ◽  
pp. 260-267 ◽  
Author(s):  
Nur Afiqah Mohamad ◽  
Vasudevan Ramachandran ◽  
Patimah Ismail ◽  
Hazlita Mohd Isa ◽  
Yoke Mun Chan ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Total Sample ◽  
Factor H ◽  
Age Related Macular Degeneration ◽  
Response To Treatment ◽  
Complement Factor ◽  
Variable Response ◽  
Intravitreal Ranibizumab ◽  
Age Related ◽  
Y402h Polymorphism

Pharmacogenetic studies indicate that a variable response to anti-vascular endothelial growth factor (VEGF) therapy in patients with neovascular form of AMD (nAMD) may be due to polymorphisms in the complement factor H gene (CFH). This study is the first to investigate the association between CFH Y402H polymorphism and the response to ranibizumab therapy in Malaysian patients with nAMD. We included 134 patients with nAMD, examined between September 2014 and February 2016. The diagnosis of nAMD was confirmed by ophthalmologic examination, before ranibizumab therapy was started. Each patient received an intravitreal injection of 0.5 mg/0.05 ml ranibizumab following a treat-and-extend (TE) regimen. Best-corrected visual acuity (BCVA) and central retinal thickness (CRT) were recorded after 3 and 6 months following the first injection and compared with the baseline values. Genotyping of Y402H (rs1061170) polymorphism was performed using PCR-RFLP and the amplified product was digested with MluCI restriction enzyme. Association between the Y402H genotypes and response to treatment was determined by a logistic regression analysis of responder (n = 49) and non-responder (n = 84) group. Significantly worse mean BCVA was observed for the CC genotype compared to the TT + CT genotype in the total sample after 6-month follow-up (p = 0.018). Comparing the baseline and 6-month point measurements, improved mean BCVA was observed in responder group, while worse mean BCVA was recorded for non-responder group. However, our regression analysis, adjusted for confounding factors, showed no significant association between the Y402H genotypes and response to treatment in nAMD patients under the recessive model (p > 0.05). Overall, our results suggest that factors other than Y402H polymorphism may be involved in the progression of nAMD after treatment with anti-VEGF agents, in Malaysian population.

Y402H Polymorphism in Complement Factor H and Age-Related Macular Degeneration in the Tunisian Population

2013 ◽  
Vol 49 (4) ◽  
pp. 177-184 ◽  
Author(s):  
I. Habibi ◽  
I. Sfar ◽  
F. Kort ◽  
H. Aounallah-Skhiri ◽  
A. Chebil ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Factor H ◽  
Age Related Macular Degeneration ◽  
Complement Factor H ◽  
Tunisian Population ◽  
Complement Factor ◽  
Age Related ◽  
Y402h Polymorphism
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