scholarly journals Concise Review: Liver Regenerative Medicine: From Hepatocyte Transplantation to Bioartificial Livers and Bioengineered Grafts

Stem Cells ◽  
2016 ◽  
Vol 35 (1) ◽  
pp. 42-50 ◽  
Author(s):  
Clara T. Nicolas ◽  
Raymond D. Hickey ◽  
Harvey S. Chen ◽  
Shennen A. Mao ◽  
Manuela Lopera Higuita ◽  
...  
Keyword(s):  
Regenerative Medicine ◽  
Hepatocyte Transplantation ◽  
Concise Review ◽  
Bioartificial Livers

scholarly journals Concise Review: Canine Diabetes Mellitus as a Translational Model for Innovative Regenerative Medicine Approaches

2019 ◽  
Vol 8 (5) ◽  
pp. 450-455 ◽  
Author(s):  
Maryam Moshref ◽  
Bonnie Tangey ◽  
Chen Gilor ◽  
Klearchos K. Papas ◽  
Peter Williamson ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Regenerative Medicine ◽  
Translational Model ◽  
Concise Review ◽  
Canine Diabetes Mellitus

scholarly journals iPSC-Derived Liver Organoids: A Journey from Drug Screening, to Disease Modeling, Arriving to Regenerative Medicine

2020 ◽  
Vol 21 (17) ◽  
pp. 6215
Author(s):  
Cristina Olgasi ◽  
Alessia Cucci ◽  
Antonia Follenzi
Keyword(s):  
Regenerative Medicine ◽  
Disease Modeling ◽  
Three Dimensional ◽  
Cell Types ◽  
High Rate ◽  
Limiting Factor ◽  
Congenital Diseases ◽  
Induced Pluripotent ◽  
Liver Organoids ◽  
Bioartificial Livers

Liver transplantation is the most common treatment for patients suffering from liver failure that is caused by congenital diseases, infectious agents, and environmental factors. Despite a high rate of patient survival following transplantation, organ availability remains the key limiting factor. As such, research has focused on the transplantation of different cell types that are capable of repopulating and restoring liver function. The best cellular mix capable of engrafting and proliferating over the long-term, as well as the optimal immunosuppression regimens, remain to be clearly well-defined. Hence, alternative strategies in the field of regenerative medicine have been explored. Since the discovery of induced pluripotent stem cells (iPSC) that have the potential of differentiating into a broad spectrum of cell types, many studies have reported the achievement of iPSCs differentiation into liver cells, such as hepatocytes, cholangiocytes, endothelial cells, and Kupffer cells. In parallel, an increasing interest in the study of self-assemble or matrix-guided three-dimensional (3D) organoids have paved the way for functional bioartificial livers. In this review, we will focus on the recent breakthroughs in the development of iPSCs-based liver organoids and the major drawbacks and challenges that need to be overcome for the development of future applications.

scholarly journals Concise Review: Multifaceted Characterization of Human Mesenchymal Stem Cells for Use in Regenerative Medicine

2017 ◽  
Vol 6 (12) ◽  
pp. 2173-2185 ◽  
Author(s):  
Rebekah M. Samsonraj ◽  
Michael Raghunath ◽  
Victor Nurcombe ◽  
James H. Hui ◽  
Andre J. van Wijnen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Regenerative Medicine ◽  
Human Mesenchymal Stem Cells ◽  
Concise Review

scholarly journals Concise Review: Adipose-Derived Stem Cells as a Novel Tool for Future Regenerative Medicine

Stem Cells ◽  
2012 ◽  
Vol 30 (5) ◽  
pp. 804-810 ◽  
Author(s):  
Hiroshi Mizuno ◽  
Morikuni Tobita ◽  
A. Cagri Uysal
Keyword(s):  
Stem Cells ◽  
Regenerative Medicine ◽  
Adipose Derived Stem Cells ◽  
Concise Review

scholarly journals Concise Review: Human Dermis as an Autologous Source of Stem Cells for Tissue Engineering and Regenerative Medicine

2015 ◽  
Vol 4 (10) ◽  
pp. 1187-1198 ◽  
Author(s):  
Natalia Vapniarsky ◽  
Boaz Arzi ◽  
Jerry C. Hu ◽  
Jan A. Nolta ◽  
Kyriacos A. Athanasiou
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Regenerative Medicine ◽  
Concise Review ◽  
Human Dermis

scholarly journals Concise Review: Cell-Based Strategies in Bone Tissue Engineering and Regenerative Medicine

2013 ◽  
Vol 3 (1) ◽  
pp. 98-107 ◽  
Author(s):  
Jinling Ma ◽  
Sanne K. Both ◽  
Fang Yang ◽  
Fu-Zhai Cui ◽  
Juli Pan ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Regenerative Medicine ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Concise Review
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