scholarly journals Stromal Tissue Rigidity Promotes Mesenchymal Stem Cell-Mediated Corneal Wound Healing Through the Transforming Growth Factor β Signaling Pathway

Stem Cells ◽  
2016 ◽  
Vol 34 (10) ◽  
pp. 2525-2535 ◽  
Author(s):  
Yun-Hsiang Yang ◽  
Ting-Lieh Hsieh ◽  
Andrea Tung-Qian Ji ◽  
Wei-Tse Hsu ◽  
Chia-Yu Liu ◽  
...  
Keyword(s):  
Wound Healing ◽  
Stem Cell ◽  
Growth Factor ◽  
Mesenchymal Stem Cell ◽  
Signaling Pathway ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Corneal Wound Healing ◽  
Corneal Wound ◽  
Stromal Tissue

scholarly journals Corneal Wound Healing Effects of Mesenchymal Stem Cell Secretome Delivered Within a Viscoelastic Gel Carrier

2019 ◽  
Vol 8 (5) ◽  
pp. 478-489 ◽  
Author(s):  
Gabriella Maria Fernandes‐Cunha ◽  
Kyung‐Sun Na ◽  
Ilham Putra ◽  
Hyun Jong Lee ◽  
Sarah Hull ◽  
...  
Keyword(s):  
Wound Healing ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Corneal Wound Healing ◽  
Corneal Wound

scholarly journals Extracellular Vesicles in the Cornea: Insights from Other Tissues

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Tina B. McKay ◽  
Vincent Yeung ◽  
Audrey E. K. Hutcheon ◽  
Xiaoqing Guo ◽  
James D. Zieske ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Wound Healing ◽  
Growth Factor ◽  
Extracellular Vesicles ◽  
Transforming Growth Factor ◽  
Phospholipid Bilayer ◽  
Human Cornea ◽  
Corneal Wound Healing ◽  
Communication Signal ◽  
Corneal Wound

Extracellular vesicles (EVs) are phospholipid bilayer-bound particles secreted by cells that have been found to be important in mediating cell-cell communication, signal transduction, and extracellular matrix remodeling. Their role in both physiological and pathological processes has been established in different tissues throughout the human body. The human cornea functions as a transparent and refractive barrier that protects the intraocular elements from the external environment. Injury, infection, or disease may cause the loss of corneal clarity by altering extracellular matrix organization within the stroma that may lead to detrimental effects on visual acuity. Over the years, numerous studies have identified many of the growth factors (e.g., transforming growth factor-β1, thrombospondin-1, and platelet-derived growth factor) important in corneal wound healing and scarring. However, the functional role of bound factors encapsulated in EVs in the context of corneal biology is less defined. In this review, we describe the discovery and characterization of EVs in the cornea. We focus on EV-matrix interactions, potential functions during corneal wound healing, and the bioactivity of mesenchymal stem cell-derived EVs. We also discuss the development of EVs as stable, drug-loaded therapeutics for ocular applications.

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