Concise Review: Stem Cell Trials Using Companion Animal Disease Models

Stem Cells ◽  
2016 ◽  
Vol 34 (7) ◽  
pp. 1709-1729 ◽  
Author(s):  
Andrew M. Hoffman ◽  
Steven W. Dow
Keyword(s):  
Stem Cell ◽  
Companion Animal ◽  
Disease Models ◽  
Animal Disease ◽  
Concise Review ◽  
Animal Disease Models

Murine and human cathepsin B exhibit similar properties: possible implications for drug discovery

2009 ◽  
Vol 390 (2) ◽  
pp. 175-179 ◽  
Author(s):  
Dejan Caglič ◽  
Gregor Kosec ◽  
Lea Bojič ◽  
Thomas Reinheckel ◽  
Vito Turk ◽  
...  
Keyword(s):  
Mouse Models ◽  
Cathepsin B ◽  
Drug Targets ◽  
Biochemical Properties ◽  
Disease Models ◽  
Preclinical Studies ◽  
Animal Disease ◽  
Transgenic Mouse Models ◽  
Animal Disease Models ◽  
Human Cathepsin

Abstract Validation of drug targets and subsequent preclinical studies are usually carried out on animal disease models, with mouse being the most commonly used. However, results from mouse models cannot always be directly related to human disease. Major discrepancies between the properties of murine and human variants were observed during the evaluation of compounds targeting cathepsins S and K. It is important, therefore, to know whether similar differences exist between murine and human cathepsin B. Thus, both enzymes were expressed and biochemically characterized. The enzymes exhibited similar biochemical properties, indicating that cathepsin B transgenic mouse models could be useful for studying its role in human pathologies.

Neuropeptide Expression in Animal Disease Models

2002 ◽  
pp. 117-120
Author(s):  
Tomas Hökfelt ◽  
Margarita Diez ◽  
Tiejun Shi ◽  
Jari Koistinaho ◽  
Dora Games ◽  
...  
Keyword(s):  
Disease Models ◽  
Animal Disease ◽  
Animal Disease Models

scholarly journals Enhanced COMP catabolism detected in serum of patients with arthritis and animal disease models through a novel capture ELISA

2012 ◽  
Vol 20 (8) ◽  
pp. 854-862 ◽  
Author(s):  
Y. Lai ◽  
X.-P. Yu ◽  
Y. Zhang ◽  
Q. Tian ◽  
H. Song ◽  
...  
Keyword(s):  
Disease Models ◽  
Animal Disease ◽  
Capture Elisa ◽  
Animal Disease Models

scholarly journals Concise Review: Increasing the Validity of Cerebrovascular Disease Models and Experimental Methods for Translational Stem Cell Research

Stem Cells ◽  
2017 ◽  
Vol 35 (5) ◽  
pp. 1141-1153 ◽  
Author(s):  
Johannes Boltze ◽  
Franziska Nitzsche ◽  
Jukka Jolkkonen ◽  
Gesa Weise ◽  
Claudia Pösel ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cerebrovascular Disease ◽  
Stem Cell Research ◽  
Experimental Methods ◽  
Disease Models ◽  
Concise Review
Sign in / Sign up

Export Citation Format

Share Document