scholarly journals Concise Review: Primary Cilia: Control Centers for Stem Cell Lineage Specification and Potential Targets for Cell-Based Therapies

Stem Cells ◽  
2016 ◽  
Vol 34 (6) ◽  
pp. 1445-1454 ◽  
Author(s):  
Josephine C. Bodle ◽  
Elizabeth G. Loboa
Keyword(s):  
Stem Cell ◽  
Primary Cilia ◽  
Cell Lineage ◽  
Lineage Specification ◽  
Concise Review ◽  
Stem Cell Lineage

Hematopoietic stem cell lineage specification

2016 ◽  
Vol 23 (4) ◽  
pp. 311-317 ◽  
Author(s):  
Marie Pouzolles ◽  
Leal Oburoglu ◽  
Naomi Taylor ◽  
Valérie S. Zimmermann
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Cell Lineage ◽  
Lineage Specification ◽  
Hematopoietic Stem ◽  
Stem Cell Lineage

scholarly journals Chromatin dynamics regulate mesenchymal stem cell lineage specification and differentiation to osteogenesis

2017 ◽  
Vol 1860 (4) ◽  
pp. 438-449 ◽  
Author(s):  
Hai Wu ◽  
Jonathan A.R. Gordon ◽  
Troy W. Whitfield ◽  
Phillip W.L. Tai ◽  
Andre J. van Wijnen ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Cell Lineage ◽  
Lineage Specification ◽  
Chromatin Dynamics ◽  
Stem Cell Lineage

scholarly journals Stem Cell Lineage Specification: You Become What You Eat

2014 ◽  
Vol 20 (3) ◽  
pp. 389-391 ◽  
Author(s):  
Clifford D.L. Folmes ◽  
Andre Terzic
Keyword(s):  
Stem Cell ◽  
Cell Lineage ◽  
Lineage Specification ◽  
Stem Cell Lineage

scholarly journals Bi-directional cell-pericellular matrix interactions direct stem cell fate

2018 ◽  
Vol 9 (1) ◽  
Author(s):  
Silvia A. Ferreira ◽  
Meghna S. Motwani ◽  
Peter A. Faull ◽  
Alexis J. Seymour ◽  
Tracy T. L. Yu ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Fate ◽  
Cell Lineage ◽  
Local Environment ◽  
Pericellular Matrix ◽  
Lineage Specification ◽  
Reciprocal Interactions ◽  
Stem Cell Lineage ◽  
Matrix Interactions ◽  
Insight Into

Abstract Modifiable hydrogels have revealed tremendous insight into how physical characteristics of cells’ 3D environment drive stem cell lineage specification. However, in native tissues, cells do not passively receive signals from their niche. Instead they actively probe and modify their pericellular space to suit their needs, yet the dynamics of cells’ reciprocal interactions with their pericellular environment when encapsulated within hydrogels remains relatively unexplored. Here, we show that human bone marrow stromal cells (hMSC) encapsulated within hyaluronic acid-based hydrogels modify their surroundings by synthesizing, secreting and arranging proteins pericellularly or by degrading the hydrogel. hMSC’s interactions with this local environment have a role in regulating hMSC fate, with a secreted proteinaceous pericellular matrix associated with adipogenesis, and degradation with osteogenesis. Our observations suggest that hMSC participate in a bi-directional interplay between the properties of their 3D milieu and their own secreted pericellular matrix, and that this combination of interactions drives fate.

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