scholarly journals Thrombopoietin/TGF-β1 Loop Regulates Megakaryocyte Extracellular Matrix Component Synthesis

Stem Cells ◽  
2016 ◽  
Vol 34 (4) ◽  
pp. 1123-1133 ◽  
Author(s):  
Vittorio Abbonante ◽  
Christian A. Di Buduo ◽  
Cristian Gruppi ◽  
Alessandro Malara ◽  
Umberto Gianelli ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Extracellular Matrix Component ◽  
Matrix Component ◽  
Tgf Β1

scholarly journals Hyperglycaemia and aberrated insulin signalling stimulate tumour progression via induction of the extracellular matrix component hyaluronan

2017 ◽  
Vol 141 (4) ◽  
pp. 791-804 ◽  
Author(s):  
Sören Twarock ◽  
Christina Reichert ◽  
Ulrike Peters ◽  
Daniel J. Gorski ◽  
Katharina Röck ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Insulin Signalling ◽  
Tumour Progression ◽  
Extracellular Matrix Component ◽  
Matrix Component

scholarly journals NRF2 Activation Inhibits Both TGF-β1- and IL-13-Mediated Periostin Expression in Fibroblasts: Benefit of Cinnamaldehyde for Antifibrotic Treatment

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Yasutaka Mitamura ◽  
Mika Murai ◽  
Chikage Mitoma ◽  
Masutaka Furue
Keyword(s):  
Dermal Fibroblasts ◽  
Treatment Modalities ◽  
Oxygen Species ◽  
Extracellular Matrix Component ◽  
Fibrotic Disease ◽  
Matrix Component ◽  
Nrf2 Activation ◽  
Life Threatening ◽  
Fibrotic Diseases ◽  
Tgf Β1

Systemic fibrosing or sclerotic disorders are life-threatening, but only very limited treatment modalities are available for them. In recent years, periostin (POSTN), a major extracellular matrix component, was established by several studies as a novel key player in the progression of systemic fibrotic disease. In this research, we revealed the involvement of oxidative stress in the expression of POSTN induced by TGF-β1 and IL-13 in dermal fibroblasts. We found that the antioxidant cinnamaldehyde activated the NRF2/HMOX1 pathway. Cinnamaldehyde also alleviated TGF-β1- and IL-13-mediated production of reactive oxygen species and subsequent POSTN upregulation in dermal fibroblasts. In contrast, NRF2 silencing abolished the cinnamaldehyde-mediated downregulation of POSTN. These results suggest that cinnamaldehyde is a broad inhibitor of POSTN expression covering both TGF-β1 and IL-13 signaling. Cinnamaldehyde may thus be beneficial for the treatment of systemic fibrotic diseases.

The impact of age on cardiac function and extracellular matrix component expression in adverse post-infarction remodeling in mice

2019 ◽  
Vol 119 ◽  
pp. 193-202 ◽  
Author(s):  
Felix Nagel ◽  
David Santer ◽  
Stefan Stojkovic ◽  
Christoph Kaun ◽  
Anne-Kristin Schaefer ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Cardiac Function ◽  
Extracellular Matrix Component ◽  
Matrix Component ◽  
The Impact

scholarly journals Cartilage link protein 1 (Crtl1), an extracellular matrix component playing an important role in heart development

2007 ◽  
Vol 310 (2) ◽  
pp. 291-303 ◽  
Author(s):  
Elaine E. Wirrig ◽  
Brian S. Snarr ◽  
Mastan R. Chintalapudi ◽  
Jessica L. O'Neal ◽  
Aimee L. Phelps ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Heart Development ◽  
Extracellular Matrix Component ◽  
Matrix Component ◽  
Link Protein
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