scholarly journals Expanded Hematopoietic Progenitor Cells Reselected for High Aldehyde Dehydrogenase Activity Demonstrate Islet Regenerative Functions

Stem Cells ◽  
2016 ◽  
Vol 34 (4) ◽  
pp. 873-887 ◽  
Author(s):  
Ayesh K. Seneviratne ◽  
Gillian I. Bell ◽  
Stephen E. Sherman ◽  
Tyler T. Cooper ◽  
David M. Putman ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Dehydrogenase Activity ◽  
Aldehyde Dehydrogenase ◽  
Hematopoietic Progenitor Cells ◽  
Hematopoietic Progenitor ◽  
Aldehyde Dehydrogenase Activity

scholarly journals Circulating Progenitor Cells Can Be Reliably Identified on the Basis of Aldehyde Dehydrogenase Activity

2007 ◽  
Vol 50 (23) ◽  
pp. 2243-2248 ◽  
Author(s):  
Thomas J. Povsic ◽  
Katherine L. Zavodni ◽  
Francine L. Kelly ◽  
Shoukang Zhu ◽  
Pascal J. Goldschmidt-Clermont ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Dehydrogenase Activity ◽  
Aldehyde Dehydrogenase ◽  
Aldehyde Dehydrogenase Activity

1079 PURIFICATION OF LIVER PROGENITOR CELLS BY USING ALDEHYDE DEHYDROGENASE ACTIVITY

2011 ◽  
Vol 54 ◽  
pp. S427
Author(s):  
L. Dollé ◽  
J. Mei ◽  
C. Empsen ◽  
J. Best ◽  
E. Van Rossen ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Dehydrogenase Activity ◽  
Aldehyde Dehydrogenase ◽  
Aldehyde Dehydrogenase Activity

scholarly journals Human progenitor cells with high aldehyde dehydrogenase activity efficiently engraft into damaged liver in a novel model

Hepatology ◽  
2009 ◽  
Vol 49 (6) ◽  
pp. 1992-2000 ◽  
Author(s):  
Ping Zhou ◽  
Sara Hohm ◽  
Yetunde Olusanya ◽  
David A. Hess ◽  
Jan Nolta
Keyword(s):  
Progenitor Cells ◽  
Dehydrogenase Activity ◽  
Aldehyde Dehydrogenase ◽  
Novel Model ◽  
Aldehyde Dehydrogenase Activity

scholarly journals Inhibition of Aldehyde Dehydrogenase-Activity Expands Multipotent Myeloid Progenitor Cells with Vascular Regenerative Function

Stem Cells ◽  
2018 ◽  
Vol 36 (5) ◽  
pp. 723-736 ◽  
Author(s):  
Tyler T. Cooper ◽  
Stephen E. Sherman ◽  
Miljan Kuljanin ◽  
Gillian I. Bell ◽  
Gilles A. Lajoie ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Dehydrogenase Activity ◽  
Aldehyde Dehydrogenase ◽  
Myeloid Progenitor ◽  
Myeloid Progenitor Cells ◽  
Aldehyde Dehydrogenase Activity

scholarly journals Direct demonstration of elevated aldehyde dehydrogenase in human hematopoietic progenitor cells

Blood ◽  
1990 ◽  
Vol 75 (10) ◽  
pp. 1947-1950 ◽  
Author(s):  
MB Kastan ◽  
E Schlaffer ◽  
JE Russo ◽  
OM Colvin ◽  
CI Civin ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Progenitor Cells ◽  
Cell Lines ◽  
Aldehyde Dehydrogenase ◽  
Bone Marrow Cells ◽  
Flow Cytometric Analysis ◽  
Hematopoietic Progenitor Cells ◽  
Hematopoietic Progenitor ◽  
Flow Cytometric ◽  
Direct Demonstration

Abstract Relative levels of cytoplasmic aldehyde dehydrogenase (ALDH) were determined in selected subpopulations of normal human bone marrow cells using a flow cytometric assay that simultaneously detects a cell surface antigen (as a marker of cell lineage and developmental stage) and the level of ALDH. The intracellular level of this enzyme has been shown to be directly related to cellular resistance to activated cyclophosphamide and is believed to be important in the survival of cells capable of repopulating marrow in autologous bone marrow transplant procedures. Western blot analysis and flow cytometric analysis of four murine cell lines with known ALDH levels were used to establish the relation between ALDH content and fluorescence with an affinity-purified anti-mouse ALDH antibody. An affinity purified anti- human ALDH antibody, characterized by immunoblotting of cytosolic extracts of cell lines with known ALDH content, was used to determine relative ALDH levels in the marrow subpopulations. We found that hematopoietic progenitor cells express the highest level of ALDH, while lymphocytes express the lowest level. Immature erythroid cells express ALDH at a level intermediate between progenitor cells and lymphocytes.

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