scholarly journals Functional Cross-Talk Between the Cellular Prion Protein and the Neural Cell Adhesion Molecule is Critical for Neuronal Differentiation of Neural Stem/Precursor Cells

Stem Cells ◽  
2014 ◽  
Vol 32 (6) ◽  
pp. 1674-1687 ◽  
Author(s):  
Kanella Prodromidou ◽  
Florentia Papastefanaki ◽  
Theodoros Sklaviadis ◽  
Rebecca Matsas
Keyword(s):  
Cell Adhesion ◽  
Neuronal Differentiation ◽  
Prion Protein ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Neural Cell Adhesion Molecule ◽  
Neural Cell ◽  
Precursor Cells ◽  
Cellular Prion Protein ◽  
Neural Cell Adhesion

scholarly journals Neural Cell Adhesion Molecule Induces Intracellular Signaling via Multiple Mechanisms of Ca2+ Homeostasis

2006 ◽  
Vol 17 (5) ◽  
pp. 2278-2286 ◽  
Author(s):  
Darya Kiryushko ◽  
Irina Korshunova ◽  
Vladimir Berezin ◽  
Elisabeth Bock
Keyword(s):  
Cell Adhesion ◽  
Neuronal Differentiation ◽  
Adhesion Molecule ◽  
Intracellular Signaling ◽  
Hippocampal Neurons ◽  
Cell Adhesion Molecule ◽  
Neural Cell Adhesion Molecule ◽  
Neural Cell ◽  
Src Family Kinases ◽  
Neural Cell Adhesion

The neural cell adhesion molecule (NCAM) plays a pivotal role in the development of the nervous system, promoting neuronal differentiation via homophilic (NCAM–NCAM) as well as heterophilic (NCAM-fibroblast growth factor receptor [FGFR]) interactions. NCAM-induced intracellular signaling has been shown to affect and be dependent on the cytoplasmic Ca2+ concentration ([Ca2+]i). However, the molecular basis of this remains unclear. In this study, we determined [Ca2+]i regulating mechanisms involved in intracellular signaling induced by NCAM. To mimic the effect of homophilic NCAM interaction on [Ca2+]i in vitro, we used a peptide derived from a homophilic binding site of NCAM, termed P2, which triggers signaling cascades similar to those activated by NCAM–NCAM interaction. We found that P2 increased [Ca2+]i in primary hippocampal neurons. This effect depended on two signaling pathways. The first pathway was associated with activation of FGFR, phospholipase Cγ, and production of diacylglycerol, and the second pathway involved Src-family kinases. Moreover, NCAM-mediated Ca2+ entry required activation of nonselective cation and T-type voltage-gated Ca2+ channels. These channels, together with the Src-family kinases, were also involved in neuritogenesis induced by physiological, homophilic NCAM interactions. Thus, unanticipated mechanisms of Ca2+ homeostasis are shown to be activated by NCAM and to contribute to neuronal differentiation.

scholarly journals The Prion Protein Controls Polysialylation of Neural Cell Adhesion Molecule 1 during Cellular Morphogenesis

PLoS ONE ◽  
2015 ◽  
Vol 10 (8) ◽  
pp. e0133741 ◽  
Author(s):  
Mohadeseh Mehrabian ◽  
Dylan Brethour ◽  
Hansen Wang ◽  
Zhengrui Xi ◽  
Ekaterina Rogaeva ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Prion Protein ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Neural Cell Adhesion Molecule ◽  
Neural Cell ◽  
Cellular Morphogenesis ◽  
Neural Cell Adhesion ◽  
Cell Adhesion Molecule 1
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