scholarly journals Concise Review: Stem Cell Therapies for Amyotrophic Lateral Sclerosis: Recent Advances and Prospects for the Future

Stem Cells ◽  
2014 ◽  
Vol 32 (5) ◽  
pp. 1099-1109 ◽  
Author(s):  
J. Simon Lunn ◽  
Stacey A. Sakowski ◽  
Eva L. Feldman
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Stem Cell ◽  
Stem Cell Therapies ◽  
Cell Therapies ◽  
Concise Review ◽  
Recent Advances ◽  
The Future ◽  
Lateral Sclerosis

scholarly journals Concise Review: Using Fat to Fight Disease: A Systematic Review of Nonhomologous Adipose-Derived Stromal/Stem Cell Therapies

Stem Cells ◽  
2018 ◽  
Vol 36 (9) ◽  
pp. 1311-1328 ◽  
Author(s):  
Marjorie E. Bateman ◽  
Amy L. Strong ◽  
Jeffrey M. Gimble ◽  
Bruce A. Bunnell
Keyword(s):  
Systematic Review ◽  
Stem Cell ◽  
Stem Cell Therapies ◽  
Cell Therapies ◽  
Concise Review ◽  
Stromal Stem Cell

The future of stem cell therapies for Parkinson disease

2020 ◽  
Vol 21 (2) ◽  
pp. 103-115 ◽  
Author(s):  
Malin Parmar ◽  
Shane Grealish ◽  
Claire Henchcliffe
Keyword(s):  
Stem Cell ◽  
Parkinson Disease ◽  
Stem Cell Therapies ◽  
Cell Therapies ◽  
The Future

scholarly journals Concise Review: Stem Cell Therapies for Neuropathic Pain

2013 ◽  
Vol 2 (5) ◽  
pp. 394-399 ◽  
Author(s):  
Veronica R. Fortino ◽  
Daniel Pelaez ◽  
Herman S. Cheung
Keyword(s):  
Neuropathic Pain ◽  
Stem Cell ◽  
Stem Cell Therapies ◽  
Cell Therapies ◽  
Concise Review

scholarly journals Risk Factors and Emerging Therapies in Amyotrophic Lateral Sclerosis

2019 ◽  
Vol 20 (11) ◽  
pp. 2616 ◽  
Author(s):  
Natalia Nowicka ◽  
Jakub Juranek ◽  
Judyta K. Juranek ◽  
Joanna Wojtkiewicz
Keyword(s):  
Risk Factors ◽  
Amyotrophic Lateral Sclerosis ◽  
Motor Neurons ◽  
Sod1 Gene ◽  
Stem Cell Therapies ◽  
Cell Therapies ◽  
Emerging Therapies ◽  
Emerging Treatments ◽  
Phase Ii And Iii ◽  
Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a fatal progressive neurodegenerative disease characterized by a permanent degeneration of both upper and lower motor neurons. Many different genes and pathophysiological processes contribute to this disease, however its exact cause remains unclear. Therefore, it is necessary to understand this heterogeneity to find effective treatments. In this review, we focus on selected environmental and genetic risk factors predisposing to ALS and highlight emerging treatments in ALS therapy. Of numerous defective genes associated with ALS, we focus on four principal genes that have been identified as definite causes of ALS: the SOD1 gene, C9orf72, TDP-43, as well as the recently identified TBK1. We also provide up-to-date information on selected environmental factors that have historically been considered as key players in ALS development and pathogenesis. In parallel to our survey of known risk factors, we also discuss emerging ALS stem cell therapies and experimental medicines currently undergoing phase II and III clinical trials.

scholarly journals Stem cell therapies for acute spinal cord injury in humans: a review

2019 ◽  
Vol 46 (3) ◽  
pp. E10 ◽  
Author(s):  
Michael C. Jin ◽  
Zachary A. Medress ◽  
Tej D. Azad ◽  
Vanessa M. Doulames ◽  
Anand Veeravagu
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Stem Cell ◽  
Cell Biology ◽  
Stem Cell Biology ◽  
Stem Cell Therapies ◽  
Cell Therapies ◽  
Recent Advances ◽  
Cord Injury

Recent advances in stem cell biology present significant opportunities to advance clinical applications of stem cell–based therapies for spinal cord injury (SCI). In this review, the authors critically analyze the basic science and translational evidence that supports the use of various stem cell sources, including induced pluripotent stem cells, oligodendrocyte precursor cells, and mesenchymal stem cells. They subsequently explore recent advances in stem cell biology and discuss ongoing clinical translation efforts, including combinatorial strategies utilizing scaffolds, biogels, and growth factors to augment stem cell survival, function, and engraftment. Finally, the authors discuss the evolution of stem cell therapies for SCI by providing an overview of completed (n = 18) and ongoing (n = 9) clinical trials.

scholarly journals The Kynurenine Pathway in Stem Cell Biology

2013 ◽  
Vol 6 ◽  
pp. IJTR.S12626 ◽  
Author(s):  
Simon P. Jones ◽  
Gilles J. Guillemin ◽  
Bruce J. Brew
Keyword(s):  
Stem Cell ◽  
Cell Biology ◽  
Critical Role ◽  
Kynurenine Pathway ◽  
Stem Cell Biology ◽  
Stem Cell Therapies ◽  
Cell Therapies ◽  
Functional Behavior ◽  
Lateral Sclerosis

The kynurenine pathway (KP) is the main catabolic pathway of the essential amino acid tryptophan. The KP has been identified to play a critical role in regulating immune responses in a variety of experimental settings. It is also known to be involved in several neuroinflammatory diseases including Huntington's disease, amyotrophic lateral sclerosis, and Alzheimer's disease. This review considers the current understanding of the role of the KP in stem cell biology. Both of these fundamental areas of cell biology have independently been the focus of a burgeoning research interest in recent years. A systematic review of how the two interact has not yet been conducted. Several inflammatory and infectious diseases in which the KP has been implicated include those for which stem cell therapies are being actively explored at a clinical level. Therefore, it is highly relevant to consider the evidence showing that the KP influences stem cell biology and impacts the functional behavior of progenitor cells.

scholarly journals Concise review: Clinical programs of stem cell therapies for liver and pancreas

Stem Cells ◽  
2013 ◽  
Vol 31 (10) ◽  
pp. 2047-2060 ◽  
Author(s):  
Giacomo Lanzoni ◽  
Tsunekazu Oikawa ◽  
Yunfang Wang ◽  
Cai-Bin Cui ◽  
Guido Carpino ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Therapies ◽  
Cell Therapies ◽  
Concise Review ◽  
Liver And Pancreas
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