scholarly journals Concise Review: The Plasticity of Stem Cell Niches: A General Property Behind Tissue Homeostasis and Repair

Stem Cells ◽  
2014 ◽  
Vol 32 (4) ◽  
pp. 852-859 ◽  
Author(s):  
Patricia Rojas-Ríos ◽  
Acaimo González-Reyes
Keyword(s):  
Stem Cell ◽  
General Property ◽  
Tissue Homeostasis ◽  
Concise Review ◽  
Stem Cell Niches

scholarly journals The Evolutionary Trade-off between Stem Cell Niche Size, Aging, and Tumorigenesis

2016 ◽  
Author(s):  
Vincent L. Cannataro ◽  
Scott A. McKinley ◽  
Colette M. St. Mary
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Genetic Drift ◽  
Stem Cell Niche ◽  
Tissue Homeostasis ◽  
Trade Off ◽  
Expected Effect ◽  
Cell Niche ◽  
Tissue Aging ◽  
Stem Cell Niches

AbstractMany epithelial tissues within large multicellular organisms are continually replenished by small independent populations of stem cells. These stem cells divide within their niches and differentiate into the constituent cell types of the tissue, and are largely responsible for maintaining tissue homeostasis. Mutations can accumulate in stem cell niches and change the rate of stem cell division and differentiation, contributing to both aging and tumorigenesis. Here, we create a mathematical model of the intestinal stem cell niche, crypt system, and epithelium. We calculate the expected effect of fixed mutations in stem cell niches and their expected effect on tissue homeostasis throughout the intestinal epithelium over the lifetime of an organism. We find that, due to the small population size of stem cell niches, fixed mutations are expected to accumulate via genetic drift and decrease stem cell fitness, leading to niche and tissue attrition, and contributing to organismal aging. We also explore mutation accumulation at various stem cell niche sizes, and demonstrate that an evolutionary trade-off exists between niche size, tissue aging, and the risk of tumorigenesis; where niches exist at a size that minimizes the probability of tumorigenesis, at the expense of accumulating deleterious mutations due to genetic drift. Finally, we show that the probability of tumorigenesis and the extent of aging trade-off differently depending on whether mutational effects confer a selective advantage, or not, in the stem cell niche.

scholarly journals Adult stem cell niches for tissue homeostasis

2021 ◽  
Author(s):  
Giuliana Mannino ◽  
Cristina Russo ◽  
Grazia Maugeri ◽  
Giuseppe Musumeci ◽  
Nunzio Vicario ◽  
...  
Keyword(s):  
Stem Cell ◽  
Adult Stem Cell ◽  
Tissue Homeostasis ◽  
Stem Cell Niches

scholarly journals Concise Review: Conceptualizing Paralogous Stem-Cell Niches and Unfolding Bone Marrow Progenitor Cell Identities

Stem Cells ◽  
2017 ◽  
Vol 36 (1) ◽  
pp. 11-21 ◽  
Author(s):  
Kevin G. Chen ◽  
Kory R. Johnson ◽  
Ronald D.G. McKay ◽  
Pamela G. Robey
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Progenitor Cell ◽  
Bone Marrow Progenitor Cell ◽  
Concise Review ◽  
Bone Marrow Progenitor ◽  
Stem Cell Niches

scholarly journals Evidence for lung epithelial stem cell niches

2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Matt L. Donne ◽  
Andrew J. Lechner ◽  
Jason R. Rock
Keyword(s):  
Stem Cell ◽  
Epithelial Stem Cell ◽  
Lung Epithelial ◽  
Stem Cell Niches

Adhesion within the stem cell niches

2009 ◽  
Vol 21 (5) ◽  
pp. 623-629 ◽  
Author(s):  
Karine Raymond ◽  
Marie-Ange Deugnier ◽  
Marisa M Faraldo ◽  
Marina A Glukhova
Keyword(s):  
Stem Cell ◽  
Stem Cell Niches
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