Mesenchymal Stem/Stromal Cells Inhibit the NLRP3 Inflammasome by Decreasing Mitochondrial Reactive Oxygen Species

Stem Cells ◽  
2014 ◽  
Vol 32 (6) ◽  
pp. 1553-1563 ◽  
Author(s):  
Joo Youn Oh ◽  
Jung Hwa Ko ◽  
Hyun Ju Lee ◽  
Ji Min Yu ◽  
Hosoon Choi ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Stromal Cells ◽  
Nlrp3 Inflammasome ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Mitochondrial Reactive Oxygen Species

scholarly journals Shiga Toxin/Lipopolysaccharide Activates Caspase-4 and Gasdermin D to Trigger Mitochondrial Reactive Oxygen Species Upstream of the NLRP3 Inflammasome

Cell Reports ◽  
2018 ◽  
Vol 25 (6) ◽  
pp. 1525-1536.e7 ◽  
Author(s):  
Jaye M. Platnich ◽  
Hyunjae Chung ◽  
Arthur Lau ◽  
Christina F. Sandall ◽  
Adom Bondzi-Simpson ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Shiga Toxin ◽  
Nlrp3 Inflammasome ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Mitochondrial Reactive Oxygen Species

scholarly journals Attenuating Effect of Chlorella Extract on NLRP3 Inflammasome Activation by Mitochondrial Reactive Oxygen Species

2021 ◽  
Vol 8 ◽  
Author(s):  
Yuya Nakashima ◽  
Kazuhito Gotoh ◽  
Soichi Mizuguchi ◽  
Daiki Setoyama ◽  
Yurie Takata ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Nlrp3 Inflammasome ◽  
Reactive Oxygen ◽  
Food Supplement ◽  
Inflammasome Activation ◽  
Oxygen Species ◽  
Mitochondrial Reactive Oxygen Species ◽  
Nlrp3 Inflammasome Activation

The NOD-like receptor family, pyrin domain-containing protein 3 (NLRP3) inflammasome has been linked to the pathogenesis of a wide variety of human diseases. Although many drugs and inhibitors have been developed to treat NLRP3-associated diseases, only limited clinical data support their efficacy and safety. Chlorella, a unicellular green alga that is widely and safely used as a food supplement, contains various antioxidants. In this study, we obtained a fat-soluble extract from Chlorella (CE) and demonstrated that it reduced NLRP3 inflammasome activation by inhibiting mitochondrial reactive oxygen species and caspase-1 activation. In addition, CE supplementation attenuated lipopolysaccharide-induced interleukin 1β transcription through activation of hypoxia-inducible factor 1α in vitro and in vivo. As Chlorella is a safe and useful food supplement, it may be a practical pharmacological approach for treating NLRP3-driven diseases.

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