scholarly journals Characterization of a Population of Cells in the Bone Marrow that Phenotypically Mimics Hematopoietic Stem Cells: Resting Stem Cells or Mystery Population?

Stem Cells ◽  
1998 ◽  
Vol 16 (1) ◽  
pp. 38-48 ◽  
Author(s):  
Troy D. Randall ◽  
Irving L. Weissman
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Hematopoietic Stem Cells ◽  
Hematopoietic Stem

Characterization of a novel decellularized bone marrow scaffold as an inductive environment for hematopoietic stem cells

2019 ◽  
Vol 7 (4) ◽  
pp. 1516-1528 ◽  
Author(s):  
Juares E. Romero Bianco ◽  
Renata Giardini Rosa ◽  
Ada Congrains-Castillo ◽  
Paulo P. Joazeiro ◽  
Stephen D. Waldman ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Hematopoietic Stem Cells ◽  
Bovine Bone ◽  
Hematopoietic Stem ◽  
Bone Marrow Study ◽  
Increasing Demand

Due to the increasing demand for a bone marrow study model, we developed a natural scaffold from decellularized bovine bone marrow (DeBM).

Preliminary phenotypic characterization of hematopoietic and non-hematopoietic stem cells from stimulated bone marrow without expansion for its use in cellular therapy

Cytotherapy ◽  
2021 ◽  
Vol 23 (5) ◽  
pp. S81
Author(s):  
C. Mancias-Guerra ◽  
I. Velasco-Ruiz ◽  
S. Sanchez-Garcia ◽  
R. Huerta-Rangel ◽  
N. Mendez-Ramirez ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Hematopoietic Stem Cells ◽  
Cellular Therapy ◽  
Phenotypic Characterization ◽  
Hematopoietic Stem

The Impact of Age and Gender on Hematopoietic Stem Cells and Immune Contexture of the Bone Marrow Microenvironment

2020 ◽  
pp. 1-6
Author(s):  
Rebar N. Mohammed
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Hematopoietic Stem Cells ◽  
Immune Cells ◽  
Absolute Number ◽  
Cell Number ◽  
Hematopoietic Stem ◽  
The Absolute ◽  
And Gender ◽  
The Impact

Hematopoietic stem cells (HSCs) are a rare population of cells that reside mainly in the bone marrow and are capable of generating and fulfilling the entire hematopoietic system upon differentiation. Thirty-six healthy donors, attending the HSCT center to donate their bone marrow, were categorized according to their age into child (0–12 years), adolescence (13–18 years), and adult (19–59 years) groups, and gender into male and female groups. Then, the absolute number of HSCs and mature immune cells in their harvested bone marrow was investigated. Here, we report that the absolute cell number can vary considerably based on the age of the healthy donor, and the number of both HSCs and immune cells declines with advancing age. The gender of the donor (male or female) did not have any impact on the number of the HSCs and immune cells in the bone marrow. In conclusion, since the number of HSCs plays a pivotal role in the clinical outcome of allogeneic HSC transplantations, identifying a younger donor regardless the gender is critical.

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