scholarly journals Numb Regulates Glioma Stem Cell Fate and Growth by Altering Epidermal Growth Factor Receptor and Skp1-Cullin-F-Box Ubiquitin Ligase Activity

Stem Cells ◽  
2012 ◽  
Vol 30 (7) ◽  
pp. 1313-1326 ◽  
Author(s):  
Xiuli Jiang ◽  
Hongyan Xing ◽  
Tae-Min Kim ◽  
Yuchae Jung ◽  
Wei Huang ◽  
...  
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Stem Cell ◽  
Growth Factor ◽  
Cell Fate ◽  
Ubiquitin Ligase ◽  
Growth Factor Receptor ◽  
Glioma Stem Cell ◽  
Stem Cell Fate ◽  
Ubiquitin Ligase Activity ◽  
Epidermal Growth

scholarly journals CG6015 controls spermatogonia transit-amplifying divisions by epidermal growth factor receptor signaling in Drosophila testes

2021 ◽  
Vol 12 (5) ◽  
Author(s):  
Jun Yu ◽  
Qianwen Zheng ◽  
Zhiran Li ◽  
Yunhao Wu ◽  
Yangbo Fu ◽  
...  
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Stem Cell ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Growth Factor Receptor ◽  
Gene Set Enrichment Analysis ◽  
Germline Stem Cell ◽  
Egfr Signaling ◽  
Egfr Signaling Pathway ◽  
Epidermal Growth

AbstractSpermatogonia transit-amplifying (TA) divisions are crucial for the differentiation of germline stem cell daughters. However, the underlying mechanism is largely unknown. In the present study, we demonstrated that CG6015 was essential for spermatogonia TA-divisions and elongated spermatozoon development in Drosophila melanogaster. Spermatogonia deficient in CG6015 inhibited germline differentiation leading to the accumulation of undifferentiated cell populations. Transcriptome profiling using RNA sequencing indicated that CG6015 was involved in spermatogenesis, spermatid differentiation, and metabolic processes. Gene Set Enrichment Analysis (GSEA) revealed the relationship between CG6015 and the epidermal growth factor receptor (EGFR) signaling pathway. Unexpectedly, we discovered that phosphorylated extracellular regulated kinase (dpERK) signals were activated in germline stem cell (GSC)-like cells after reduction of CG6015 in spermatogonia. Moreover, Downstream of raf1 (Dsor1), a key downstream target of EGFR, mimicked the phenotype of CG6015, and germline dpERK signals were activated in spermatogonia of Dsor1 RNAi testes. Together, these findings revealed a potential regulatory mechanism of CG6015 via EGFR signaling during spermatogonia TA-divisions in Drosophila testes.

scholarly journals Active targeting co-delivery of therapeutic Sur siRNA and an antineoplastic drug via epidermal growth factor receptor-mediated magnetic nanoparticles for synergistic programmed cell death in glioblastoma stem cells

2020 ◽  
Vol 4 (2) ◽  
pp. 574-588
Author(s):  
Xueqin Wang ◽  
Ruifang Li ◽  
Yongxia Zhu ◽  
Zichao Wang ◽  
Huiru Zhang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cell Death ◽  
Epidermal Growth Factor Receptor ◽  
Stem Cell ◽  
Magnetic Nanoparticles ◽  
Growth Factor ◽  
Growth Factor Receptor ◽  
Active Targeting ◽  
Glioblastoma Stem Cell ◽  
Epidermal Growth

An EGFR-targeted theranostic composite, and targeted co-delivery of therapeutic siRNAs and DOX for glioblastoma stem cell treatments.

scholarly journals Expression of fringe is down regulated by Gurken/Epidermal Growth Factor Receptor signalling and is required for the morphogenesis of ovarian follicle cells

2000 ◽  
Vol 113 (21) ◽  
pp. 3781-3794 ◽  
Author(s):  
D. Zhao ◽  
D. Clyde ◽  
M. Bownes
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Cell Fate ◽  
Ovarian Follicle ◽  
Growth Factor Receptor ◽  
Signal Transduction Pathway ◽  
Follicle Cells ◽  
Egg Chambers ◽  
Epidermal Growth

Signalling by the Gurken/Epidermal Growth Factor Receptor (Grk/EGFR) pathway is involved in epithelial cell fate decision, morphogenesis and axis establishment in Drosophila oogenesis. In the search for genes downstream of the Grk/EGFR signal transduction pathway (STP), we isolated a number of genes that are components of other STPs. One of them is a known gene, called fringe (fng). Drosophila fng encodes a putative secreted protein that is required at other development stages for mediating interactions between dorsal and ventral cells via Notch signalling. Here we show that fng has a dynamic expression pattern in oogenesis and that its expression in specific groups of follicle cells along the anterior-posterior and dorsal-ventral axes is defined by the repression of fng by Grk. Interfering with fng expression using antisense RNA experiments resulted in a typical fng mutant phenotype in the wing, and malformed egg chambers and abnormal organisation of the follicle cells in the ovaries, revealing that fng is essential in oogenesis for the proper formation of the egg chamber and for epithelial morphogenesis. This has been confirmed by re-examination of fng mutants and analysis of fng mutant clones in oogenesis.

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