scholarly journals An Endogenous Vitamin K-Dependent Mechanism Regulates Cell Proliferation in the Brain Subventricular Stem Cell Niche

Stem Cells ◽  
2012 ◽  
Vol 30 (4) ◽  
pp. 719-731 ◽  
Author(s):  
Aurore Gely-Pernot ◽  
Valérie Coronas ◽  
Thomas Harnois ◽  
Laetitia Prestoz ◽  
Nathalie Mandairon ◽  
...  
2021 ◽  
Vol 12 ◽  
Author(s):  
Mónica L. García-Gómez ◽  
Adriana Garay-Arroyo ◽  
Berenice García-Ponce ◽  
María de la Paz Sánchez ◽  
Elena R. Álvarez-Buylla

The root stem cell niche (SCN) of Arabidopsis thaliana consists of the quiescent center (QC) cells and the surrounding initial stem cells that produce progeny to replenish all the tissues of the root. The QC cells divide rather slowly relative to the initials, yet most root tissues can be formed from these cells, depending on the requirements of the plant. Hormones are fundamental cues that link such needs with the cell proliferation and differentiation dynamics at the root SCN. Nonetheless, the crosstalk between hormone signaling and the mechanisms that regulate developmental adjustments is still not fully understood. Developmental transcriptional regulatory networks modulate hormone biosynthesis, metabolism, and signaling, and conversely, hormonal responses can affect the expression of transcription factors involved in the spatiotemporal patterning at the root SCN. Hence, a complex genetic–hormonal regulatory network underlies root patterning, growth, and plasticity in response to changing environmental conditions. In this review, we summarize the scientific literature regarding the role of hormones in the regulation of QC cell proliferation and discuss how hormonal signaling pathways may be integrated with the gene regulatory network that underlies cell fate in the root SCN. The conceptual framework we present aims to contribute to the understanding of the mechanisms by which hormonal pathways act as integrators of environmental cues to impact on SCN activity.


Science ◽  
2011 ◽  
Vol 334 (6058) ◽  
pp. 990-992 ◽  
Author(s):  
E. M. Fast ◽  
M. E. Toomey ◽  
K. Panaram ◽  
D. Desjardins ◽  
E. D. Kolaczyk ◽  
...  

2013 ◽  
Vol 22 (7) ◽  
pp. 1027-1041 ◽  
Author(s):  
Paula Grazielle Chaves da Silva ◽  
Jeanne L. Benton ◽  
David C. Sandeman ◽  
Barbara S. Beltz

Spine ◽  
2009 ◽  
Vol 34 (21) ◽  
pp. 2278-2287 ◽  
Author(s):  
Helena B. Henriksson ◽  
Maria Thornemo ◽  
Camilla Karlsson ◽  
Olle Hägg ◽  
Katarina Junevik ◽  
...  

Development ◽  
2018 ◽  
Vol 145 (17) ◽  
pp. dev156315 ◽  
Author(s):  
Eugene A. Albert ◽  
Olga A. Puretskaia ◽  
Nadezhda V. Terekhanova ◽  
Anastasia Labudina ◽  
Christian Bökel

2012 ◽  
Vol 109 (4) ◽  
pp. 1317-1322 ◽  
Author(s):  
M. V. Gomez-Gaviro ◽  
C. E. Scott ◽  
A. K. Sesay ◽  
A. Matheu ◽  
S. Booth ◽  
...  

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