Modified Starches as Direct Compression Excipients - Effect of Physical and Chemical Modifications on Tablet Properties: A Review

2018 ◽  
Vol 71 (1-2) ◽  
pp. 1800040 ◽  
Author(s):  
Mariam V. Lawal
Keyword(s):  
Direct Compression ◽  
Chemical Modifications ◽  
Modified Starches ◽  
Tablet Properties ◽  
Physical And Chemical

scholarly journals Karakterisasi sifat fisiko kimia pati bengkuang (Pachirrhyzus erosus) dan pati ganyong (Canna edulis Kerr) modifikasi [Characteristization on physico-chemical properties of modified canna (Canna edulis Kerr.) and jicama (Pachirrhyzus erosus) starches]

2021 ◽  
Vol 26 (1) ◽  
pp. 25
Author(s):  
Sri Haryani Anwar ◽  
Yeni Chandra Dewi ◽  
Novi Safriani
Keyword(s):  
Chemical Properties ◽  
National Standard ◽  
Chemical Modifications ◽  
Solubility In Water ◽  
Food Industries ◽  
Swelling Power ◽  
Physico Chemical ◽  
Moisture Treatment ◽  
Modified Starches ◽  
Physical And Chemical

Modification of native starch is needed mainly to increase its solubility in water thus broaden its application in food industries. On the other hand, modification of canna and jicama starches have rarely been applied. Physical and chemical modifications of starches are conducted to modify starch characteristics. The research aimed to investigate the physico-chemical properties of canna and jicama starches that had been modified chemically and physically. Chemical modifications which were conducted included modification via substitution with Octenyl Succinate Anhydride (OSA) and hydrolysis using hydrochloric acid (HCl), while physical modification was conducted via the Heat Moisture Treatment (HMT). The starch physico-chemical characteristics evaluated were degree of acid (DA), swelling power, degree of substitution (DS), moisture, ash, fat, and fiber contents. The analysis results showed that moisture, ash, fat, and fiber contents of native canna and jicama starches were not significantly different from those of modified ones. The result also revealed that the type of starches and modification methods increased the swelling power significantly (P≤0,05). The DS of modified canna dan jicama starches were 0.0246% and 0.0176%, respectively. While the DA of modified canna and jicama starches were 0.14% and 0.18%, respectively. This DA values of modified starches by HCL hydrolysis had meet the Indonesian National Standard (SNI 01-2593-1992) which is maximum of 5% for food application.Keywords: canna starch, jicama starch, HMT modification, modified starch, OSA modification 

Study of physical and chemical modifications induced by 50MeV Li3+ ion beam in polymers

2014 ◽  
Vol 94 ◽  
pp. 54-57 ◽  
Author(s):  
Paramjit Singh ◽  
Satyendra Kumar ◽  
Rajendra Prasad ◽  
Rajesh Kumar
Keyword(s):  
Ion Beam ◽  
Chemical Modifications ◽  
Physical And Chemical

scholarly journals Effect of a co-processed excipient on the disintegration and drug release profile of ibuprofen tablets

Bio-Research ◽  
2020 ◽  
Vol 18 (1) ◽  
Author(s):  
BB Mohammed ◽  
EJ John ◽  
NK Ajuji
Keyword(s):  
Drug Release ◽  
Release Profile ◽  
Angle Of Repose ◽  
Oral Dosage ◽  
Direct Compression ◽  
Drug Release Profile ◽  
Disintegration Time ◽  
Crushing Strength ◽  
Tablet Properties ◽  
Spray Dried

Tablets at present, remain the most preferred oral dosage form because of many advantages they offer to formulators as well as physicians and patients. The objective of this work was to determine the effect of co-processing on the disintegration and drug-release profile of ibuprofen tablets prepared from a co-processed excipient. The co-processed excipient (CE) containing lactose, gelatin and mucin in the ratio 90:9:1 was prepared using co-fusion. The excipient was evaluated for its physicochemical properties and then used to formulate tablets with the addition of a disintegrant by direct compression. The tablets were evaluated for their tablet properties and compared with tablets prepared with cellactose- 80® (CEL) and spray dried lactose® (SDL) and a physical mix (PM) of the co-processed ingredient. Results from evaluation of CE showed that flow rate, angle of repose, Carr’s index and Hausner’s ratio were 5.28 g/sec, 20.30o, 23.75 % and 1.31, respectively. Tablets prepared with CE had friability (0%), crushing strength (5.25) KgF, disintegration time (3 mins) and T50% (2 mins). For CEL, friability (0.4 %), crushing strength (7.25) KgF, disintegration time (1 min) and T50% (2 mins); SDL, friability (1.57 %), crushing strength (7.50) KgF, disintegration time (4 mins) and T50% (2 mins) and PM, friability (2.38 %), crushing strength (5.00) KgF, disintegration time (1 min) and T50% (2 mins). In conclusion, the disintegration time and drug release profile for CE was not superior but compared favorably with CEL, SDL and PM.  

scholarly journals DESIGN AND IN VITRO EVALUATION OF EXTENDED RELEASE TABLET OF NATEGLINIDE

2018 ◽  
Vol 8 (5-s) ◽  
pp. 235-239
Author(s):  
NILESH M MAHAJAN ◽  
Kalyanee Wanaskar ◽  
Yogesh Bhutada ◽  
Raju Thenge ◽  
Vaibhav Adhao
Keyword(s):  
Drug Release ◽  
Extended Release ◽  
In Vitro Release ◽  
Matrix Tablet ◽  
Direct Compression ◽  
In Vitro Drug Release ◽  
Release Studies ◽  
Tablet Properties ◽  
Vitro Release

The aim of present study is to formulate and evaluate extended release matrix tablet of Nateglinide by direct compression method using different polymer like HPMC K4 and HPMC K15. Matrix tablet of nateglidine were prepared in combination with the polymer HPMC K4, HPMC K15, along with the excipients and the formulations were evaluated for tablet properties and in vitro drug release studies. Nateglinide matrix tablet prepared by using polymer such as HPMC K4 and HPMC K15,  it was found that HPMC K15 having higher viscosity as compare to HPMC K4 therefore different concentration of polymer were studied to extend the drug release up to 12 h. The tablets of Nateglinide prepared by direct compression had acceptable physical characteristics and satisfactory drug release. The study demonstrated that as far as the formulations were concerned, the selected polymers proved to have an acceptable flexibility in terms of in-vitro release profile. In present the study the percent drug release for optimize batch was found to 94.62%.  Hence it can be conclude that Nateglinide extended release matrix tablet can prepared by using HPMC. The swollen tablet also maintains its physical integrity during the drug release study Keywords: Tablet, in-vitro drug release, Nateglinide, HPMC

scholarly journals Acetylation and Evaluation of Taro Boloso-I Starch as Directly Compressible Excipient in Tablet Formulation

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Afewerk Getachew ◽  
Zewdu Yilma ◽  
Solomon Abrha
Keyword(s):  
The United States ◽  
High Yield ◽  
Lower Sensitivity ◽  
Direct Compression ◽  
Flow Properties ◽  
Tablet Formulations ◽  
Starch Modifications ◽  
Physical And Chemical ◽  
Evaluation Parameters ◽  
States Pharmacopeia

Taro Boloso-I (TB1), a newly improved Colocasia esculenta variety, is a potential source of starch with high yield. However, to improve some limitations of the native starches (NS), such as flowability and compactibility, different physical and chemical starch modifications have been employed. Acetylation is one of the chemical modifications which improves the flow and compaction of the NS, which are prerequisite during direct compression (DC) of tablets. Hence, in this study, TB1 starch was acetylated using acetic anhydride and evaluated as an ideal excipient for direct compression. Starch acetates (SA) with a degree of substitution (DS) of 0.072 (SA1) and 0.695 (SA2) were produced and evaluated. FTIR spectra of the SAs were used to verify the acetylation of the NS. Powder flow evaluation parameters showed significant improvement in the flow properties of the NS following acetylation. In addition, the swelling power, solubility, and compactibility were also improved. Tensile strength (TS) of the tablets comprising SAs only, SA1 (41.40) and SA2 (63.43 Kg/cm2), was significantly higher than tablets made of the NS (31.96) and Starch 1500® (15.12 Kg/cm2). The SAs also showed lower sensitivity towards lubrication than the NS and Starch 1500® as lower lubricant sensitivity ratios were recorded. In addition, tablets comprising the SAs satisfactorily accommodated at least up to 50 % w/w paracetamol—compared to 30 % w/w by Starch 1500®—upon DC processing. The paracetamol tablets comprising SAs also complied with the United States Pharmacopeia specifications for disintegration and dissolution studies. Therefore, taking all the facts into consideration, the SAs could be potential DC excipients in tablet formulations.

scholarly journals CYCLIC BUTYLENE TEREPHTHALATE AND PROMISING FIELD OF APPLICATION

2017 ◽  
Vol 60 (7) ◽  
pp. 4
Author(s):  
Nikolay A. Chukov ◽  
Muslim A. Mikitaev ◽  
Mukhamed Kh. Ligidov ◽  
Musa T. Bashorov ◽  
Vladimir N. Shogenov ◽  
...  
Keyword(s):  
Carbon Fibers ◽  
Atmospheric Pressure ◽  
Ring Opening ◽  
Glass Fibers ◽  
Ring Opening Polymerization ◽  
Chemical Modifications ◽  
Butylene Terephthalate ◽  
Cyclic Butylene Terephthalate ◽  
Physical And Chemical ◽  
Structure Properties

Due to its unique characteristics, cyclic butylene terephthalate is used in novel developments of chemical industry. This article represents the review of the latest achievements in the field of processing, structure, properties of cyclic butylene terephthalate, its physical and chemical modifications as well as composites and nanocomposites based on it. In recent years, cyclic butylene terephthalate oligomers have drawn the attention of scientists. The oligomers can be acquired through the chemical reaction of cyclo-depolymerization and used as materials for ring-opening polymerization reactions. This method of polymerization has a variety of advantages compared to a standard method of synthesis polyesters. One of the main advantages of this method includes the capability to make polymerization reactions at standard atmospheric pressure, low required temperature, no side effects and obtaining a completely finished product as an outcome. The unique qualities of cyclic butylene terephthalate make it a promising material to be used as matrix for a variety of nano- and microcomposites and super concentrate. This study analyzes some of the examples of applying CBT as a super concentrate for creating materials like carbon nanotubes, laminated silicates, carbon fibers and glass fibers. In the majority of studies, the addition of nano-sized fillers into CBT leads to amplification of mechanical properties. In the cases of usage as fillers for carbon fibers and glass fibers, the possibility of replacing thermosetting resins with CBT is currently being researched. It could possibly lead to increase in manufacturability of carbon fibers and fiberglass and increase its possible area of application. Cyclic butylene terephthalate can also be used as a viscosity modifier for synthetic rubbers. In this case it can be both plasticizer and enhancing agent.For citation:Chukov N.A., Mikitaev M.A., Ligidov M.Kh., Bashorov M.T., Shogenov V.N., Pakhomov S.I. Cyclic butylene terephthalate and promising field of application. Izv. Vyssh. Uchebn. Zaved. Khim. Khim. Tekhnol. 2017. V. 60. N 7. P. 4-13.

scholarly journals Chemical modifications of castor oil: A review

2019 ◽  
Vol 102 (3) ◽  
pp. 199-217
Author(s):  
Ntsako Portia Chauke ◽  
Hembe Elie Mukaya ◽  
Diakanua Bavon Nkazi
Keyword(s):  
Renewable Resources ◽  
Castor Oil ◽  
Fossil Fuels ◽  
Chemical Properties ◽  
Environmental Concerns ◽  
Chemical Modifications ◽  
Plant Oil ◽  
Natural Oils ◽  
Physical And Chemical ◽  
And Chemical Properties

The necessity of using petrochemicals for the development of polymers has been deteriorating because of the depletion in fossil fuels and environmental concerns such as the effect of greenhouse gases, global warming, and increasing population. Research has shown a shift from petroleum-based fuels to plant oil–based fuels in order to shift to renewable resources. Natural oils such as castor oil have shown competitive physical and chemical properties as compared to fossil fuels. The use of natural oils has gained a lot of research interest due to the fact that they are renewable, affordable, and environmentally friendly. Bio-oils are versatile because they have various derivatives and can be used in different grades based on the application in various industries such as agriculture, food, paper, and electronics. Bio-binders have been considered as the most promising materials for the different applications. In this review, the processes of chemical modifications of castor oil are discussed.

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