A Study of Hydroxyethyl Starch. Part V. Some Physicochemical and Biological Properties of Hydroxyethyl Starch Isolated from the Blood and Urine, and Limit Hydroxyethyl Starch

1984 ◽  
Vol 36 (8) ◽  
pp. 269-272
Author(s):  
M. Yoshida ◽  
T. Nozaka ◽  
T. Kishikawa
Keyword(s):  
Hydroxyethyl Starch ◽  
Biological Properties ◽  
Physicochemical And Biological Properties

scholarly journals The Influence of Bloom Index, Endotoxin Levels and Polyethylene Glycol Succinimidyl Glutarate Crosslinking on the Physicochemical and Biological Properties of Gelatin Biomaterials

Biomolecules ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1003
Author(s):  
Zhuning Wu ◽  
Stefanie H. Korntner ◽  
Jos Olijve ◽  
Anne Maria Mullen ◽  
Dimitios I. Zeugolis
Keyword(s):  
Elastic Modulus ◽  
Polyethylene Glycol ◽  
Enzymatic Degradation ◽  
Structural Integrity ◽  
Biological Response ◽  
Biological Properties ◽  
Compression Stress ◽  
Free Amine ◽  
Amine Content ◽  
Physicochemical And Biological Properties

In the medical device sector, bloom index and residual endotoxins should be controlled, as they are crucial regulators of the device’s physicochemical and biological properties. It is also imperative to identify a suitable crosslinking method to increase mechanical integrity, without jeopardising cellular functions of gelatin-based devices. Herein, gelatin preparations with variable bloom index and endotoxin levels were used to fabricate non-crosslinked and polyethylene glycol succinimidyl glutarate crosslinked gelatin scaffolds, the physicochemical and biological properties of which were subsequently assessed. Gelatin preparations with low bloom index resulted in hydrogels with significantly (p < 0.05) lower compression stress, elastic modulus and resistance to enzymatic degradation, and significantly higher (p < 0.05) free amine content than gelatin preparations with high bloom index. Gelatin preparations with high endotoxin levels resulted in films that induced significantly (p < 0.05) higher macrophage clusters than gelatin preparations with low endotoxin level. Our data suggest that the bloom index modulates the physicochemical properties, and the endotoxin content regulates the biological response of gelatin biomaterials. Although polyethylene glycol succinimidyl glutarate crosslinking significantly (p < 0.05) increased compression stress, elastic modulus and resistance to enzymatic degradation, and significantly (p < 0.05) decreased free amine content, at the concentration used, it did not provide sufficient structural integrity to support cell culture. Therefore, the quest for the optimal gelatin crosslinker continues.

The depolymerization of chitosan: effects on physicochemical and biological properties

2004 ◽  
Vol 281 (1-2) ◽  
pp. 45-54 ◽  
Author(s):  
Shirui Mao ◽  
Xintao Shuai ◽  
Florian Unger ◽  
Michael Simon ◽  
Dianzhou Bi ◽  
...  
Keyword(s):  
Biological Properties ◽  
Physicochemical And Biological Properties

Rational design and fabrication of a β-dicalcium silicate-based multifunctional cement with potential for root canal filling treatment

2014 ◽  
Vol 2 (24) ◽  
pp. 3830-3838 ◽  
Author(s):  
Xianyan Yang ◽  
Min Liu ◽  
Yu Zhao ◽  
Hongyu Jia ◽  
Sanzhong Xu ◽  
...  
Keyword(s):  
Root Canal ◽  
Rational Design ◽  
Biological Properties ◽  
Dicalcium Silicate ◽  
Root Canal Therapy ◽  
Root Canal Filling ◽  
Physicochemical And Biological Properties

Gypsum-introduced, CaO-rich dicalcium silicate-based cements exhibit multifunctional physicochemical and biological properties and meet some challenging criteria in root canal therapy.

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