Front Cover: Implementation of analytical quality‐by‐design and green analytical chemistry approaches for the development of robust and ecofriendly UHPLC analytical method for quantification of chrysin

2020 ◽  
Vol 3 (9) ◽  
Author(s):  
Teenu Sharma ◽  
Atul Jain ◽  
Sumant Saini ◽  
OP Katare ◽  
Bhupinder Singh
Keyword(s):  
Analytical Chemistry ◽  
Analytical Method ◽  
Quality By Design ◽  
Green Analytical Chemistry ◽  
Analytical Quality ◽  
Front Cover

scholarly journals Implementing Green Analytical Methodologies Using Solid-Phase Microextraction: A Review

Molecules ◽  
2020 ◽  
Vol 25 (22) ◽  
pp. 5297
Author(s):  
Kayla M. Billiard ◽  
Amanda R. Dershem ◽  
Emanuela Gionfriddo
Keyword(s):  
Analytical Chemistry ◽  
Sample Preparation ◽  
Analytical Method ◽  
Analytical Methods ◽  
Solid Phase Microextraction ◽  
Method Development ◽  
Assessment Tool ◽  
Solid Phase ◽  
Assessment Tools ◽  
Green Analytical Chemistry

Implementing green analytical methodologies has been one of the main objectives of the analytical chemistry community for the past two decades. Sample preparation and extraction procedures are two parts of analytical method development that can be best adapted to meet the principles of green analytical chemistry. The goal of transitioning to green analytical chemistry is to establish new methods that perform comparably—or superiorly—to traditional methods. The use of assessment tools to provide an objective and concise evaluation of the analytical methods’ adherence to the principles of green analytical chemistry is critical to achieving this goal. In this review, we describe various sample preparation and extraction methods that can be used to increase the greenness of a given analytical method. We gave special emphasis to modern microextraction technologies and their important contributions to the development of new green analytical methods. Several manuscripts in which the greenness of a solid-phase microextraction (SPME) technique was compared to other sample preparation strategies using the Green Analytical Procedure Index (GAPI), a green assessment tool, were reviewed.

scholarly journals Analytical Quality by Design with the Lifecycle Approach: A Modern Epitome for Analytical Method Development

2019 ◽  
Vol 65 (2) ◽  
pp. 37-44 ◽  
Author(s):  
Maher Abdulrazzaq Alhakeem ◽  
Mihaela Violeta Ghica ◽  
Cristina Dinu Pîrvu ◽  
Valentina Anuța ◽  
Lăcrămioara Popa
Keyword(s):  
Risk Assessment ◽  
Analytical Method ◽  
Method Development ◽  
Quality By Design ◽  
Control Process ◽  
Analytical Techniques ◽  
Analytical Quality ◽  
Comprehensive Knowledge ◽  
Development Concept ◽  
Target Profile

AbstractQuality by Design is the methodical method to development concept that starts with the predefined objects. The method put emphasis on the process of development of a product, the control process, which is built on risk management and comprehensive knowledge of science. The concept of QbD applied to analytical method development is known now as AQbD (Analytical Quality by Design). Comprehension of the Analytical Target Profile (ATP) and the risk assessment for the variables that can have an impact on the productivity of the developed analytical method can be the main principles of the AQbD. Inside the method operable design region (MODR), the AQbD permits the movements of the analytical methods. This paper has been produced to discuss various views of analytical scientists, the comparison with conventional methods, and the phases of the analytical techniques.

scholarly journals GREEN ANALYTICAL METHOD FOR QUANTIFICATION OF SECNIDAZOLE IN TABLETS BY HPLC-UV

2018 ◽  
Vol 2 (2) ◽  
pp. 20-26
Author(s):  
Jéssica Lima ◽  
Ana Kogawa ◽  
Hérida Regina Nunes Salgado
Keyword(s):  
Analytical Chemistry ◽  
Particle Size ◽  
Analytical Method ◽  
Mobile Phase ◽  
Toxic Waste ◽  
Green Analytical Chemistry ◽  
Injection Volume ◽  
As Stress ◽  
Routine Quality Control

A simple, rapid, economic and green analytical method was validated for the determination of secnidazole in tablets. The aim was to contribute to the green analytical chemistry since it has low use of organic solvent and low production of toxic waste. For the HPLC-UV method, the mobile phase was a mixture of purified water + 0.7 % acetic acid and ethanol (78:22, v/v), flow rate was 1.3 mL min-1 on column CN Phenomenex Luna (250 x 4.60 mm, 5 μm particle size), injection volume was 20 μL with UV detection at 318 nm and retention time of 4.26 minutes. The method was linear over the concentration range of 5-100 μg mL-1 (r = 0.9998) with limits of detection and quantitation of 0.533 e 1.615 μg mL-1, respectively. The precision of the method showed RSD less than 2 %. The accuracy determined by the average recoveries was 99.58 %. The secnidazole tablets were subjected to oxidation, acid, alkaline, neutral and photolysis degradation as stress conditions and the method was considered as indicative of stability. The method is adequate and safe to be a great alternative method in routine quality control analyzes for determination and quantification of secnidazole tablets.

Green analytical solutions for sample preparation: solid phase microextraction and related techniques

2020 ◽  
Vol 5 (8) ◽  
Author(s):  
Emanuela Gionfriddo
Keyword(s):  
Analytical Chemistry ◽  
Sample Preparation ◽  
Analytical Method ◽  
Analytical Methods ◽  
Solid Phase Microextraction ◽  
Method Development ◽  
Solid Phase ◽  
Green Analytical Chemistry ◽  
Chemistry Community

AbstractFor at least three decades, the analytical chemistry community is striving to apply the principles of Green Chemistry to the development of analytical methods. Many efforts have been made to outline the concept of Green Analytical Chemistry, which helped to redefine analytical procedures and drastically changed the philosophy of analytical method development. This book chapter describes the 12 principles of Green Analytical Chemistry and various methodologies for the assessment of the greenness of analytical methods. The three main steps in the analytical method development – sample preparation, separation and detection- are described in a “green perspective”. Special emphasis is given to the description of green sample preparation procedures, in particular to Solid Phase Microextraction, that, since its introduction in 1989 by Janusz Pawliszyn, has drastically revolutionized the methodology of sample preparation, providing a convenient and green alternative to already existing methods.

Developing a Validated HPLC Method for Quantification of Ceftazidime Employing Analytical Quality by Design and Monte Carlo Simulations

2021 ◽  
Author(s):  
Ranjot Kaur ◽  
Sumant Saini ◽  
Asha Patel ◽  
Teenu Sharma ◽  
Ripandeep Kaur ◽  
...  
Keyword(s):  
Monte Carlo ◽  
Monte Carlo Simulations ◽  
Flow Rate ◽  
Analytical Method ◽  
Mobile Phase ◽  
Quality By Design ◽  
Hplc Method ◽  
Superior Performance ◽  
Analytical Quality ◽  
Method Performance

Abstract Background Ceftazidime, a third-generation cephalosporin, is widely used in the treatment of lung infections, often given as “off-label” nebulization. There is need for developing a sensitive and robust analytical method to compute aerodynamic properties of ceftazidime following nebulization. Objective The current study entails development of a simple, accurate and sensitive high-performance liquid chromatography method (HPLC) for ceftazidime estimation, employing the principles of analytical quality-by-design (AQbD) and Monte Carlo simulations. Methods Selection of critical material attributes (CMAs) affecting method performance was accomplished by factor screening exercise. Subsequently, the influential CMAs, i.e., mobile phase ratio and flow rate, were systemically optimized using a face-centred cubic design for the chosen critical analytical attributes (CAAs). The factor relationship(s) between CMAs and CAAs was explored employing 3 D-response surface and 2 D-contour plots, followed by numerical as well as graphical optimization, for establishing the optimal chromatographic conditions. The obtained method operable design region was validated by Monte Carlo simulations for defect rate analysis. Results The optimized HPLC conditions for estimating ceftazidime were acetonitrile to acetic acid solution (75:25) as mobile phase at a flow rate of 0.7 mL/min, leading to Rt of 4.5 min and peak tailing ≤ 2. Validation studies, as per ICH Q2(R1) guidance’s, demonstrated high sensitivity, accuracy and efficiency of the developed analytical method with LOD of 0.075 and LOQ of 0.227 µg/mL. Application of this chromatographic method was extrapolated for determining aerodynamic performance by nebulizing ceftazidime at flow rate of 15 L/min using next-generation impactor. The study indicated superior performance, sensitivity and specificity of the developed analytical system for quantifying ceftazidime. Conclusions Application of AQbD approach, coupled with Monte Carlo simulations, aided in developing a robust HPLC method for estimation of ceftazidime per se and on various stages of impactor.

scholarly journals Comprehensive Assessment of Flow and Other Analytical Methods Dedicated to the Determination of Zinc in Water

Molecules ◽  
2021 ◽  
Vol 26 (13) ◽  
pp. 3914
Author(s):  
Paweł Kościelniak ◽  
Paweł Mateusz Nowak ◽  
Joanna Kozak ◽  
Marcin Wieczorek
Keyword(s):  
Analytical Chemistry ◽  
Green Chemistry ◽  
Analytical Method ◽  
Analytical Methods ◽  
Green Analytical Chemistry ◽  
General Quality ◽  
Analytical Strategies ◽  
High Degree

An original strategy to evaluate analytical procedures is proposed and applied to verify if the flow-based methods, generally favorable in terms of green chemistry, are competitive when their evaluation also relies on other criteria. To this end, eight methods for the determination of zinc in waters, including four flow-based ones, were compared and the Red–Green–Blue (RGB) model was exploited. This model takes into account several features related to the general quality of an analytical method, namely, its analytical efficiency, compliance with the green analytical chemistry, as well as practical and economic usefulness. Amongst the investigated methods, the best was the flow-based spectrofluorimetric one, and a negative example was that one involving a flow module, ICP ionization and MS detection, which was very good in analytical terms, but worse in relation to other aspects, which significantly limits its overall potential. Good assessments were also noted for non-flow electrochemical methods, which attract attention with a high degree of balance of features and, therefore, high versatility. The original attempt to confront several worldwide accepted analytical strategies, although to some extent subjective and with limitations, provides interesting information and indications, establishing a novel direction towards the development and evaluation of analytical methods.

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