Ultrasound-assisted dispersive micro-solid-phase extraction using hydrophobic thiolated ionic liquids immobilized on gold nanoparticles for the preconcentration and determination of amino acids in human plasma samples

2018 ◽  
Vol 1 (6) ◽  
pp. 419-429 ◽  
Author(s):  
Fahimeh Zare ◽  
Ramin Jannesar ◽  
M. K. Purkait ◽  
Mehrorang Ghaedi
Keyword(s):  
Amino Acids ◽  
Gold Nanoparticles ◽  
Ionic Liquids ◽  
Solid Phase Extraction ◽  
Human Plasma ◽  
Solid Phase ◽  
Phase Extraction ◽  
Plasma Samples ◽  
Ultrasound Assisted

scholarly journals A New Solid-Phase Extraction Method for Determination of Pantoprazole in Human Plasma Using High-Performance Liquid Chromatography

2019 ◽  
Vol 7 (11) ◽  
pp. 1757-1761 ◽  
Author(s):  
Dragica Zendelovska ◽  
Emilija Atanasovska ◽  
Kalina Gjorgjievska ◽  
Kristina Pavlovska ◽  
Krume Jakjovski ◽  
...  
Keyword(s):  
Solid Phase Extraction ◽  
Human Plasma ◽  
Extraction Method ◽  
High Performance ◽  
Solid Phase ◽  
Hplc Method ◽  
Phase Extraction ◽  
Good Precision ◽  
Plasma Samples

BACKGROUND: A new simple, selective and accurate high-performance liquid chromatographic (HPLC) method utilising solid-phase extraction for the determination of pantoprazole in human plasma samples has been developed. AIM: The purpose of this paper was developing a new HPLC method suitable for the determination of pantoprazole in plasma samples, which enables simple and rapid isolation and concentration of the analysed drug.METHODS: The chromatographic separation was accomplished on a LiChroCart LiChrospher 60 RP select B column using a mobile phase composed of 0.2 % (V/V) water solution of triethylamine (pH 7) and acetonitrile (58:42, V/V) followed by UV detection was at 280 nm. The solid-phase extraction method using LiChrolut RP-18 (200 mg, 3 ml) was applied to the obtained good separation of investigated drug from endogenous plasma components. Best results were achieved when plasma samples were buffered with 0.1 mol/L KH2PO4 (pH 9) before extraction, eluted and reconstituted with acetonitrile and 0.001 mol/L NaOH after extraction, respectively. RESULTS: The standard calibration curves showed good linearity within the range of 25.0-4000.0 ng/mL with a correlation coefficient greater than 0.996. Retention times of pantoprazole and internal standard, lansoprazole was 4.1 and 6.0 min respectively. The limit of quantification was 25.0 ng/mL. For intra- and inter-day precision relative standard deviations ranged from 4.2 to 9.3%. The relative errors for stability investigations were ranged from 0.12 to -10.5%. CONCLUSION: This method has good precision and accuracy and was successfully applied to the pharmacokinetic and bioequivalence study of 40 mg pantoprazole in healthy volunteers.

Ultrasound-assisted magnetic solid-phase extraction for the determination of some transition metals in Orujo spirit samples by capillary electrophoresis

2016 ◽  
Vol 190 ◽  
pp. 263-269 ◽  
Author(s):  
Rosa M. Peña Crecente ◽  
Carlha Gutiérrez Lovera ◽  
Julia Barciela García ◽  
Carlos Herrero Latorre ◽  
Sagrario García Martín
Keyword(s):  
Capillary Electrophoresis ◽  
Transition Metals ◽  
Solid Phase Extraction ◽  
Solid Phase ◽  
Magnetic Solid Phase Extraction ◽  
Phase Extraction ◽  
Magnetic Solid ◽  
Ultrasound Assisted
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