Detection of congenital heart disease ( CHD ) in the first trimester

Sonography ◽  
2021 ◽  
Author(s):  
Alison Lee‐Tannock
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
First Trimester

Generalized Bone Changes and Thrombocytopenic Purpura in Association with Intrauterine Rubella

PEDIATRICS ◽  
1965 ◽  
Vol 36 (2) ◽  
pp. 264-268
Author(s):  
AARON R. RAUSEN ◽  
ROBERT D. LONDON ◽  
ABRAHAM MIZRAHI ◽  
LOUIS Z. COOPER
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Rubella Virus ◽  
Congenital Heart ◽  
Newborn Infants ◽  
First Trimester ◽  
Long Bones ◽  
Thrombocytopenic Purpura ◽  
Bone Changes ◽  
First Trimester Of Pregnancy

Two newborn infants are presented whose mothers had rubella in the first trimester of pregnancy. Both infants were born with thrombocytopenic purpura and suggestive evidence of a hemolytic disorder. The second infant had congenital heart disease as well. Roentgenographic changes in the metaphyseal ends of several long bones, observed in the first infant at 3 days of age, regressed completely by 2 months of age. The second infant had roentgenographic evidence of metaphyseal changes of a lesser degree, limited to the distal ends of the femora. These changes were no longer present at 6 weeks of age. Both infants were shown to be harboring an interfering agent with the characteristics of the rubella virus.

scholarly journals 2076927 Is the Brain-Sparing Effect Described in Fetuses With Congenital Heart Disease Evident in the First Trimester?

2015 ◽  
Vol 41 (4) ◽  
pp. S52
Author(s):  
Reem Abu-Rustum ◽  
M. Fouad Ziade ◽  
Assaad Kesrouani ◽  
Sameer Abu-Rustum ◽  
Linda Daou
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
First Trimester ◽  
Sparing Effect ◽  
The Brain

Reversed end-diastolic umbilical flow in a first-trimester fetus with congenital heart disease

1998 ◽  
Vol 18 (10) ◽  
pp. 1001-1005 ◽  
Author(s):  
Antoni Borrell ◽  
Dolors Costa ◽  
Josep M. Martinez ◽  
M. Teresa Farre ◽  
Montserrat Palacio ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
First Trimester

scholarly journals Incidence and risk factors of congenital heart disease in Qingdao: a prospective cohort study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Xiao Jin ◽  
Wei Ni ◽  
Guolan Wang ◽  
Qin Wu ◽  
Jun Zhang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Congenital Heart Disease ◽  
Logistic Regression ◽  
Cohort Study ◽  
Heart Disease ◽  
Congenital Heart ◽  
First Trimester ◽  
Chd Risk ◽  
Positive Rate ◽  
Chd Risk Factors

Abstract Background Many studies have been conducted to assess the incidence of congenital heart disease (CHD). However, results were greatly inconsistent among these studies with a broad range of findings. Methods A prospective census-based cohort study was conducted in Qingdao, China, from August 1, 2018 to April 30, 2019. All of the local registered pregnant women were continuously investigated and followed from 15 to 20 weeks of gestation to delivery, tracking the CHD cases in both the fetal and neonatal stages. A logistic regression model was applied to assess the association between CHD and possible risk factors. Results The positive rate of prenatal CHD screening was 14.36 per 1000 fetuses and the incidence of CHD was 9.38 per 1000 live births. Results from logistic regression indicated that, living in the countryside (odds ratio, (OR): 0.771; 95% confidence interval, (CI): 0.628–0.946) and having a childbearing history (OR: 0.802; 95%CI: 0.676–0.951) were negatively associated with CHD. However, twin pregnancy (OR: 1.957, 95% CI: 1.245–3.076), illness in the first trimester (OR: 1.306; 95% CI: 1.048–1.628), a family history of CHD (OR: 7.156; 95% CI: 3.293–15.552), and having a child with a birth defect (OR: 2.086; 95% CI: 1.167–3.731) were positively associated with CHD. Conclusion CHD is a serious health problem in Qingdao. The CHD incidence found in this study was similar to existing research. The positive rate of prenatal CHD screening was higher than the incidence of neonatal CHD. Moreover, CHD risk factors were identified in our study, and our findings may have great implications for formation CHD intervention strategies.

scholarly journals Analysis of commonly expressed genes between first trimester fetal heart and placenta cell types in the context of congenital heart disease

2022 ◽  
Author(s):  
Rebecca Wilson ◽  
Victor Yuan ◽  
Jennifer Alexander Courtney ◽  
Alyssa Tipler ◽  
James Cnota ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Endothelial Cells ◽  
Heart Disease ◽  
Congenital Heart ◽  
Fetal Heart ◽  
Reduction Process ◽  
Cell Types ◽  
First Trimester ◽  
Cellular Respiration ◽  
Oxidation Reduction

Congenital heart disease (CHD) is often associated with fetal growth abnormalities. During the first trimester of pregnancy, the heart and placenta develop concurrently, and share key developmental pathways. Hence, it is hypothesized that defective morphogenesis of either organ is synergistically linked. However, many studies determined to understand the mechanisms behind CHD overlook the contribution of the placenta. In this study, we aimed to identify commonly expressed genes between first trimester heart and placenta cells using two publicly available single cell sequencing databases. Using a systematic computational approach, we identified 328 commonly expressed genes between heart and placenta endothelial cells and enrichment in pathways including Vasculature Development (GO:0001944, FDR 2.90E-30), and Angiogenesis (GO:0001525, FDR 1.18E-27). We also found, in comparison with fetal heart endothelial cells, 197 commonly expressed genes with placenta extravillous trophoblasts, 128 with cytotrophoblasts and 80 with syncytiotrophoblasts, and included genes such as FLT1, GATA2, ENG and CDH5. Finally, comparison of first trimester cardiomyocytes and placenta cytotrophoblasts revealed 53 commonly expressed genes and enrichment in biological processes integral to cellular function including Cellular Respiration (GO:0045333; FDR 5.05E-08), Ion Transport (GO:0006811; FDR 2.08E-02), and Oxidation-Reduction Process (GO:0055114; FDR 1.58E-07). Overall, our results identify specific genes and cellular pathways common between first trimester fetal heart and placenta cells which if disrupted may concurrently contribute to the developmental perturbations resulting in CHD.

scholarly journals Does First-Trimester Screening Modify the Natural History of Congenital Heart Disease?

Circulation ◽  
2017 ◽  
Vol 135 (11) ◽  
pp. 1045-1055 ◽  
Author(s):  
Hana Jicinska ◽  
Pavel Vlasin ◽  
Michal Jicinsky ◽  
Ilga Grochova ◽  
Viktor Tomek ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Natural History ◽  
Congenital Heart ◽  
First Trimester ◽  
First Trimester Screening ◽  
Trimester Screening ◽  
History Of

scholarly journals First Trimester Plasma Glucose Values in Women without Diabetes are Associated with Risk for Congenital Heart Disease in Offspring

2018 ◽  
Vol 195 ◽  
pp. 275-278 ◽  
Author(s):  
Emmi I.T. Helle ◽  
Preston Biegley ◽  
Joshua W. Knowles ◽  
Joseph B. Leader ◽  
Sarah Pendergrass ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Plasma Glucose ◽  
Congenital Heart ◽  
First Trimester
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