Development of a Noninvasive Method for Early Stage Lung Cancer Diagnosis Based on Methylation Analysis ofSHOX2andPTGER4

Small Methods ◽  
2019 ◽  
Vol 3 (2) ◽  
pp. 1800424
Author(s):  
Wei Yin ◽  
Junjie Zhu ◽  
Diego Gonzalez-Rivas ◽  
Ming Liu ◽  
Nan Song ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Diagnosis ◽  
Early Stage ◽  
Noninvasive Method ◽  
Methylation Analysis ◽  
Early Stage Lung Cancer ◽  
Lung Cancer Diagnosis ◽  
Stage Lung Cancer

scholarly journals Feasibility of Bronchial Washing Fluid‐Based Approach to Early‐Stage Lung Cancer Diagnosis

2019 ◽  
Vol 24 (7) ◽  
Author(s):  
Jeong‐Seon Ryu ◽  
Jun Hyeok Lim ◽  
Myoung Kyu Lee ◽  
Seung Jae Lee ◽  
Hyun‐Jung Kim ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Diagnosis ◽  
Early Stage ◽  
Early Stage Lung Cancer ◽  
Lung Cancer Diagnosis ◽  
Bronchial Washing ◽  
Stage Lung Cancer

Early-Stage Lung Cancer Diagnosis by Deep Learning-Based Spectroscopic Analysis of Circulating Exosomes

ACS Nano ◽  
2020 ◽  
Vol 14 (5) ◽  
pp. 5435-5444 ◽  
Author(s):  
Hyunku Shin ◽  
Seunghyun Oh ◽  
Soonwoo Hong ◽  
Minsung Kang ◽  
Daehyeon Kang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Deep Learning ◽  
Cancer Diagnosis ◽  
Spectroscopic Analysis ◽  
Early Stage ◽  
Early Stage Lung Cancer ◽  
Lung Cancer Diagnosis ◽  
Stage Lung Cancer

Early-stage lung cancer: diagnosis and treatment

2006 ◽  
Vol 11 (1) ◽  
pp. 9-12 ◽  
Author(s):  
Tatsuo Ohira ◽  
Yasuhiro Suga ◽  
Yoshitaka Nagatsuka ◽  
Jitsuo Usuda ◽  
Masahiro Tsuboi ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Diagnosis ◽  
Early Stage ◽  
Diagnosis And Treatment ◽  
Early Stage Lung Cancer ◽  
Lung Cancer Diagnosis ◽  
Stage Lung Cancer

Disparities in Early-Stage Lung Cancer Diagnosis Before and after Implementation of Screening Guidelines

2019 ◽  
Vol 229 (4) ◽  
pp. S276-S277
Author(s):  
Tamar B. Nobel ◽  
Smita Sihag ◽  
Paolo Boffetta ◽  
Prasad Adusumilli ◽  
James M. Isbell ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Diagnosis ◽  
Early Stage ◽  
Early Stage Lung Cancer ◽  
Screening Guidelines ◽  
Lung Cancer Diagnosis ◽  
Before And After ◽  
Stage Lung Cancer

scholarly journals Analysis of Lung Flute-collected Sputum for Lung Cancer Diagnosis

2015 ◽  
Vol 10 ◽  
pp. BMI.S26883 ◽  
Author(s):  
Jian Su ◽  
Nigar Anjuman ◽  
Maria A. Guarnera ◽  
Howard Zhang ◽  
Sanford A. Stass ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Diagnosis ◽  
Early Stage ◽  
Polymerase Chain Reaction Analysis ◽  
Diagnostic Efficiency ◽  
Early Stage Lung Cancer ◽  
Lung Cancer Patients ◽  
Lung Cancer Diagnosis ◽  
Sputum Volume ◽  
Former Smokers

Molecular analysis of sputum can help diagnose lung cancer. We have demonstrated that Lung Flute can be used to collect sputum from individuals who cannot spontaneously expectorate sputum. The objective of this study is to further evaluate the performance of the Lung Flute by comparing the characteristics of parallel samples collected with and without the Lung Flute and the usefulness for diagnosis of lung cancer. Fifty-six early-stage lung cancer patients (40 current smokers and 16 former smokers) and 73 cancer-free individuals (52 current smokers and 21 former smokers) were instructed to spontaneously cough and use Lung Flute for sputum sampling. Sputum cytology and polymerase chain reaction analysis of three miRNAs (miRs-21, 31, and 210) were performed in the specimens. All 92 current smokers and 11 (28.7%) of 37 former smokers spontaneously expectorated sputum and also produced sputum when using the Lung Flute. Twenty-seven former smokers (70.3%) who could not spontaneously expectorate sputum, however, were able to produce sputum when using the Lung Flute. The specimens were of low respiratory origin without contamination from other sources, eg, saliva. There was no difference of sputum volume and cell populations, diagnostic efficiency of cytology, and analysis of the miRNAs in the specimens collected by the two approaches. Analysis of the sputum miRNAs produced 83.93% sensitivity and 87.67% specificity for identifying lung cancer. Therefore, sputum collected by the Lung Flute has comparable features as spontaneously expectorated sputum. Using the Lung Flute enables former smokers who cannot spontaneously expectorate to provide adequate sputum to improve sputum collection for lung cancer diagnosis.

Sign in / Sign up

Export Citation Format

Share Document