scholarly journals Strong Penetration‐Induced Effective Photothermal Therapy by Exosome‐Mediated Black Phosphorus Quantum Dots (Small 49/2021)

Small ◽  
2021 ◽  
Vol 17 (49) ◽  
pp. 2170258
Author(s):  
Jing Liu ◽  
Kezhen Yi ◽  
Qi Zhang ◽  
Hang Xu ◽  
Xingang Zhang ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Photothermal Therapy ◽  
Black Phosphorus ◽  
Black Phosphorus Quantum Dots

Ultrasmall black phosphorus quantum dots: synthesis, characterization, and application in cancer treatment

The Analyst ◽  
2018 ◽  
Vol 143 (23) ◽  
pp. 5822-5833 ◽  
Author(s):  
Mingqian Wang ◽  
Ying Liang ◽  
Yajun Liu ◽  
Guohong Ren ◽  
Zhicheng Zhang ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Cancer Treatment ◽  
Photothermal Therapy ◽  
Black Phosphorus ◽  
Black Phosphorus Quantum Dots

We synthesized black phosphorus quantum dots with good fluorescence performance and excellent biocompatibility, and highlighted their great potential in the photothermal therapy of cancer.

scholarly journals Biomimetic black phosphorus quantum dots-based photothermal therapy combined with anti-PD-L1 treatment inhibits recurrence and metastasis in triple-negative breast cancer

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Peiqi Zhao ◽  
Yuanlin Xu ◽  
Wei Ji ◽  
Shiyong Zhou ◽  
Lanfang Li ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quantum Dots ◽  
Triple Negative Breast Cancer ◽  
Photothermal Therapy ◽  
Triple Negative ◽  
Black Phosphorus ◽  
High Rate ◽  
Immune Memory ◽  
Immunotherapy Strategy ◽  
Black Phosphorus Quantum Dots

Abstract Background Triple-negative breast cancer (TNBC) is a highly aggressive malignant disease with a high rate of recurrence and metastasis, few effective treatment options and poor prognosis. Here, we designed and constructed a combined photothermal immunotherapy strategy based on cancer cell membrane-coated biomimetic black phosphorus quantum dots (BBPQDs) for tumor-targeted photothermal therapy and anti-PD-L1 mediated immunotherapy. Results BBPQDs have good photothermal conversion efficiency and can efficiently target tumor cells through homologous targeting and tumor homing. Under near infrared irradiation, we found that BBPQDs kill tumors directly through photothermal effects and induce dendritic cells maturation. In vivo studies have confirmed that the combined photothermal immunotherapy strategy displays a stronger antitumor activity than anti-PD-L1 monotherapy. In addition, BBPQDs-mediated photothermal therapy in combination with anti-PD-L1 treatment inhibit tumor recurrence and metastasis by reprograming the immunosuppressive tumor microenvironment into an immune-active microenvironment, and promoting the local and systemic antitumor immune response. We further found that the combined photothermal immunotherapy strategy can produce an immune memory effect against tumor rechallenge. Conclusions This study provides a novel therapeutic strategy for inhibiting the recurrence and metastasis of TNBC, with broad application prospects.

Strong Penetration‐Induced Effective Photothermal Therapy by Exosome‐Mediated Black Phosphorus Quantum Dots

Small ◽  
2021 ◽  
pp. 2104585
Author(s):  
Jing Liu ◽  
Kezhen Yi ◽  
Qi Zhang ◽  
Hang Xu ◽  
Xingang Zhang ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Photothermal Therapy ◽  
Black Phosphorus ◽  
Black Phosphorus Quantum Dots

Sequentially Triggered Delivery System of Black Phosphorus Quantum Dots with Surface Charge-Switching Ability for Precise Tumor Radiosensitization

ACS Nano ◽  
2018 ◽  
Vol 12 (12) ◽  
pp. 12401-12415 ◽  
Author(s):  
Leung Chan ◽  
Pan Gao ◽  
Wenhua Zhou ◽  
Chaoming Mei ◽  
Yanyu Huang ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Surface Charge ◽  
Delivery System ◽  
Black Phosphorus ◽  
Black Phosphorus Quantum Dots
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