De Novo Engineering of Metal–Organic Framework‐Printed In Vitro Diagnostic Devices for Specific Capture and Release of Tumor Cells

Small ◽  
2021 ◽  
pp. 2103590
Author(s):  
Jieying Liang ◽  
Jian Liu ◽  
Megan S. Lord ◽  
Yu Wang ◽  
Kang Liang
Keyword(s):  
Tumor Cells ◽  
De Novo ◽  
Metal Organic Framework ◽  
In Vitro Diagnostic ◽  
Metal Organic ◽  
Capture And Release ◽  
Organic Framework

The cascade catalysis of the porphyrinic zirconium metal-organic framework PCN-224-Cu for CO2 conversion to alcohols

2021 ◽  
Author(s):  
Shi-Chao Qi ◽  
Zhi-Hui Yang ◽  
Rong-Rong Zhu ◽  
Xiao-Jie Lu ◽  
Ding-Ming Xue ◽  
...  
Keyword(s):  
Metal Organic Framework ◽  
Co2 Conversion ◽  
Cascade System ◽  
The Past ◽  
Highly Efficient ◽  
Metal Organic ◽  
Zirconium Metal ◽  
Organic Framework ◽  
Cascade Catalysis

Reproducing the highly efficient catalytic cascade system to mimic life behaviors in vitro has been intensively investigated over the past few decades. However, except the biocatalysis with enzymes, most chemocatalytic...

scholarly journals In Vitro Toxicity Study of a Porous Iron(III) Metal‒Organic Framework

Molecules ◽  
2019 ◽  
Vol 24 (7) ◽  
pp. 1211 ◽  
Author(s):  
Gongsen Chen ◽  
Xin Leng ◽  
Juyuan Luo ◽  
Longtai You ◽  
Changhai Qu ◽  
...  
Keyword(s):  
Metal Organic Framework ◽  
Drug Carrier ◽  
In Vitro Cytotoxicity ◽  
In Vitro Toxicity ◽  
Porous Iron ◽  
Dapi Staining ◽  
Toxicological Assessment ◽  
Metal Organic ◽  
Organic Framework

A MIL series metal‒organic framework (MOF), MIL-100(Fe), was successfully synthesized at the nanoscale and fully characterized by TEM, TGA, XRD, FTIR, DLS, and BET. A toxicological assessment was performed using two different cell lines: human normal liver cells (HL-7702) and hepatocellular carcinoma (HepG2). In vitro cytotoxicity of MIL-100(Fe) was evaluated by the MTT assay, LDH releasing rate assay, DAPI staining, and annexin V/PI double staining assay. The safe dose of MIL-100(Fe) was 80 μg/mL. It exhibited good biocompatibility, low cytotoxicity, and high cell survival rate (HL-7702 cells’ viability >85.97%, HepG2 cells’ viability >91.20%). Therefore, MIL-100(Fe) has a potential application as a drug carrier.

scholarly journals Metal–Organic Framework-Based Chemo-Photothermal Combinational System for Precise, Rapid, and Efficient Antibacterial Therapeutics

Pharmaceutics ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 463 ◽  
Author(s):  
Wu ◽  
Fu ◽  
Zhou ◽  
Wang ◽  
Feng ◽  
...  
Keyword(s):  
Laser Irradiation ◽  
Photothermal Therapy ◽  
Metal Organic Framework ◽  
Global Public Health ◽  
Zeolitic Imidazolate Frameworks ◽  
Porous Carrier ◽  
Metal Organic ◽  
Organic Framework

Rapid increase of antimicrobial resistance has become an urgent threat to global public health. In this research, since photothermal therapy is a potential antibacterial strategy, which is less likely to cause resistance, a metal–organic framework-based chemo-photothermal combinational system was constructed. Zeolitic imidazolate frameworks-8 (ZIF-8), a porous carrier with unique features such as high loading and pH-sensitive degradation, was synthesized, and then encapsulated photothermal agent indocyanine green (ICG). First, ICG with improved stability in ZIF-8 (ZIF-8-ICG) can effectively produce heat in response to NIR laser irradiation for precise, rapid, and efficient photothermal bacterial ablation. Meanwhile, Zn2+ ions released from ZIF-8 can inhibit bacterial growth by increasing the permeability of bacterial cell membrane and further strengthen photothermal therapy efficacy by reducing the heat resistance of bacteria. Study showed that bacteria suffered from significant changes in morphology after treatment with ZIF-8-ICG under laser irradiation. The combinational chemo-hyperthermia therapy of ZIF-8-ICG could thoroughly ablate murine subcutaneous abscess induced by methicillin-resistant Staphylococcus aureus (MRSA), exhibiting a nearly 100% bactericidal ratio. Both in vitro and in vivo safety evaluation confirmed that ZIF-8-ICG was low toxic. Overall, our researches demonstrated that ZIF-8-ICG has great potential to be served as an alternative to antibiotics in combating multidrug-resistant bacterial pathogens.

scholarly journals Reversible Capture and Release of Cl2 and Br2 with a Redox-Active Metal–Organic Framework

2017 ◽  
Vol 139 (16) ◽  
pp. 5992-5997 ◽  
Author(s):  
Yuri Tulchinsky ◽  
Christopher H. Hendon ◽  
Kirill A. Lomachenko ◽  
Elisa Borfecchia ◽  
Brent C. Melot ◽  
...  
Keyword(s):  
Metal Organic Framework ◽  
Redox Active ◽  
Active Metal ◽  
Metal Organic ◽  
Capture And Release ◽  
Redox Active Metal ◽  
Organic Framework

Lanthanide Metal–Organic Framework Nanoprobes for the In Vitro Detection of Cardiac Disease Markers

2019 ◽  
Vol 11 (47) ◽  
pp. 43989-43995 ◽  
Author(s):  
Xingjun Li ◽  
Shanyong Zhou ◽  
Shan Lu ◽  
Datao Tu ◽  
Wei Zheng ◽  
...  
Keyword(s):  
Cardiac Disease ◽  
Metal Organic Framework ◽  
Disease Markers ◽  
Metal Organic ◽  
Lanthanide Metal ◽  
Organic Framework

scholarly journals Electrochemically addressable trisradical rotaxanes organized within a metal–organic framework

2015 ◽  
Vol 112 (36) ◽  
pp. 11161-11168 ◽  
Author(s):  
Paul R. McGonigal ◽  
Pravas Deria ◽  
Idan Hod ◽  
Peyman Z. Moghadam ◽  
Alyssa-Jennifer Avestro ◽  
...  
Keyword(s):  
Solid State ◽  
Near Infrared ◽  
De Novo ◽  
Metal Organic Framework ◽  
Paramagnetic Resonance ◽  
Interlocked Molecules ◽  
Redox Active ◽  
Metal Organic ◽  
Electron Paramagnetic ◽  
Organic Framework

The organization of trisradical rotaxanes within the channels of a Zr6-based metal–organic framework (NU-1000) has been achieved postsynthetically by solvent-assisted ligand incorporation. Robust ZrIV–carboxylate bonds are forged between the Zr clusters of NU-1000 and carboxylic acid groups of rotaxane precursors (semirotaxanes) as part of this building block replacement strategy. Ultraviolet–visible–near-infrared (UV-Vis-NIR), electron paramagnetic resonance (EPR), and 1H nuclear magnetic resonance (NMR) spectroscopies all confirm the capture of redox-active rotaxanes within the mesoscale hexagonal channels of NU-1000. Cyclic voltammetry measurements performed on electroactive thin films of the resulting material indicate that redox-active viologen subunits located on the rotaxane components can be accessed electrochemically in the solid state. In contradistinction to previous methods, this strategy for the incorporation of mechanically interlocked molecules within porous materials circumvents the need for de novo synthesis of a metal–organic framework, making it a particularly convenient approach for the design and creation of solid-state molecular switches and machines. The results presented here provide proof-of-concept for the application of postsynthetic transformations in the integration of dynamic molecular machines with robust porous frameworks.

A core–shell metal–organic-framework (MOF)-based smart nanocomposite for efficient NIR/H2O2-responsive photodynamic therapy against hypoxic tumor cells

2017 ◽  
Vol 5 (13) ◽  
pp. 2390-2394 ◽  
Author(s):  
Hui-Juan Cai ◽  
Ting-Ting Shen ◽  
Jian Zhang ◽  
Chang-Fu Shan ◽  
Jian-Guo Jia ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Cells ◽  
Metal Organic Framework ◽  
Core Shell ◽  
Metal Organic ◽  
Bio Imaging ◽  
Hypoxic Tumor ◽  
Organic Framework

In this work, core–shell MOF-based smart nanocomposite UCNPs/MB@ZIF-8@catalase has been constructed for bio-imaging and efficient NIR/H2O2-responsive photodynamic therapy against hypoxic tumor cells.

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