Molecularly Imprinted Synthetic Antibodies: From Chemical Design to Biomedical Applications

Small ◽  
2020 ◽  
Vol 16 (27) ◽  
pp. 1906644 ◽  
Author(s):  
Jingjing Xu ◽  
Haohan Miao ◽  
Jixiang Wang ◽  
Guoqing Pan
Keyword(s):  
Biomedical Applications ◽  
Molecularly Imprinted ◽  
Chemical Design ◽  
Synthetic Antibodies

Progress in Molecularly Imprinted Polymers for Biomedical Applications

2019 ◽  
Vol 22 (2) ◽  
pp. 78-88 ◽  
Author(s):  
Jane Ru Choi ◽  
Kar Wey Yong ◽  
Jean Yu Choi ◽  
Alistair C. Cowie
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Biomedical Applications ◽  
Cell Imaging ◽  
Review Article ◽  
Future Perspectives ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Target Analytes ◽  
Methods Of Synthesis ◽  
Near Future

Background: Molecularly Imprinted Polymers (MIPs), a type of biomimetic materials have attracted considerable interest owing to their cost-effectiveness, good physiochemical stability, favorable specificity and selectivity for target analytes, and long shelf life. These materials are able to mimic natural recognition entities, including biological receptors and antibodies, providing a versatile platform to achieve the desirable functionality for various biomedical applications. Objective: In this review article, we introduce the most recent development of MIPs to date. We first highlight the advantages of using MIPs for a broad range of biomedical applications. We then review their various methods of synthesis along with their latest progress in biomedical applications, including biosensing, drug delivery, cell imaging and drug discovery. Lastly, the existing challenges and future perspectives of MIPs for biomedical applications are briefly discussed. Conclusion: We envision that MIPs may be used as potential materials for diverse biomedical applications in the near future.

Recognition and Absorption of the Water-soluble X-ray Contrast Medium Iodixanol using Molecularly Imprinted Polymers for Biomedical Applications

2008 ◽  
Vol 1138 ◽  
Author(s):  
Zhan Liu ◽  
David G. Bucknall ◽  
Mark G. Allen
Keyword(s):  
Contrast Medium ◽  
Molecularly Imprinted Polymers ◽  
Biomedical Applications ◽  
Crosslink Density ◽  
Binding Capacity ◽  
Water Soluble ◽  
Spectrometric Analysis ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
X Ray

AbstractThis work presents the study on the recognition and absorption of the water-soluble X-ray contrast medium iodixanol in aqueous solution using synthetic molecularly imprinted polymers (MIPs). A non-covalent imprinting technique was applied to prepare iodixanol-imprinted polymers using 4-vinylpyridine as the functional monomer and ethylene glycol dimethacrylate as the cross-linker. The effects of quantity of iodixanol templates, the crosslink density, and the solvent were studied in terms of the binding capacity and imprint effect of the polymers. UV-vis spectrometric analysis shows that the highest binding capacity achieved is 284 mg iodixanol per gram of dry polymer, which is 8.8 times higher than the binding capacity of the non-imprinted control polymers (NIPs). SEM and BET surface analysis have also been performed to investigate the effect of morphology and porosity on the binding capacities of polymers.

Protein-Size Molecularly Imprinted Polymer Nanogels as Synthetic Antibodies, by Localized Polymerization with Multi-initiators

2012 ◽  
Vol 25 (7) ◽  
pp. 1048-1051 ◽  
Author(s):  
Pinar Çakir ◽  
Arnaud Cutivet ◽  
Marina Resmini ◽  
Bernadette Tse Sum Bui ◽  
Karsten Haupt
Keyword(s):  
Molecularly Imprinted Polymer ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Protein Size ◽  
Synthetic Antibodies

Molecularly Imprinted Polymer Nanoparticles as Potential Synthetic Antibodies for Immunoprotection against HIV

2019 ◽  
Vol 11 (10) ◽  
pp. 9824-9831 ◽  
Author(s):  
Jingjing Xu ◽  
Franck Merlier ◽  
Bérangère Avalle ◽  
Vincent Vieillard ◽  
Patrice Debré ◽  
...  
Keyword(s):  
Molecularly Imprinted Polymer ◽  
Polymer Nanoparticles ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Synthetic Antibodies

Chemical Design of Nanozymes for Biomedical Applications

2021 ◽  
Author(s):  
Min Wei ◽  
Jiyoung Lee ◽  
Fan Xia ◽  
Peihua Lin ◽  
Xi Hu ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Chemical Design
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