Solution-Controlled Conformational Switching of an Anchored Wireframe DNA Nanostructure

Small ◽  
2018 ◽  
Vol 15 (1) ◽  
pp. 1803628 ◽  
Author(s):  
Ian T. Hoffecker ◽  
Sijie Chen ◽  
Andreas Gådin ◽  
Alessandro Bosco ◽  
Ana I. Teixeira ◽  
...  
Keyword(s):  
Conformational Switching ◽  
Dna Nanostructure

Visualization of Dynamic Conformational Switching of the G-Quadruplex in a DNA Nanostructure

2010 ◽  
Vol 132 (46) ◽  
pp. 16311-16313 ◽  
Author(s):  
Yuta Sannohe ◽  
Masayuki Endo ◽  
Yousuke Katsuda ◽  
Kumi Hidaka ◽  
Hiroshi Sugiyama
Keyword(s):  
Conformational Switching ◽  
Dna Nanostructure ◽  
G Quadruplex

scholarly journals Tuning flavin environment to detect and control light-induced conformational switching in Drosophila cryptochrome

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Siddarth Chandrasekaran ◽  
Connor M. Schneps ◽  
Robert Dunleavy ◽  
Changfan Lin ◽  
Cristina C. DeOliveira ◽  
...  
Keyword(s):  
Side Reactions ◽  
Resonance Spectroscopy ◽  
Conformational Switching ◽  
Spin Resonance ◽  
Degradation Activity ◽  
Recognition Motifs ◽  
Cellular Turnover ◽  
Control Light ◽  
Dynamics Simulations ◽  
And Control

AbstractLight-induction of an anionic semiquinone (SQ) flavin radical in Drosophila cryptochrome (dCRY) alters the dCRY conformation to promote binding and degradation of the circadian clock protein Timeless (TIM). Specific peptide ligation with sortase A attaches a nitroxide spin-probe to the dCRY C-terminal tail (CTT) while avoiding deleterious side reactions. Pulse dipolar electron-spin resonance spectroscopy from the CTT nitroxide to the SQ shows that flavin photoreduction shifts the CTT ~1 nm and increases its motion, without causing full displacement from the protein. dCRY engineered to form the neutral SQ serves as a dark-state proxy to reveal that the CTT remains docked when the flavin ring is reduced but uncharged. Substitutions of flavin-proximal His378 promote CTT undocking in the dark or diminish undocking in the light, consistent with molecular dynamics simulations and TIM degradation activity. The His378 variants inform on recognition motifs for dCRY cellular turnover and strategies for developing optogenetic tools.

In situ injection of dual-delivery PEG based MMP-2 sensitive hydrogels for enhanced tumor penetration and chemo-immune combination therapy

Nanoscale ◽  
2021 ◽  
Author(s):  
Jianqin Yan ◽  
Zhuangzhuang Zhang ◽  
xiaohui Zhan ◽  
Keqi Chen ◽  
Yuji Pu ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Cancer Treatment ◽  
Deep Penetration ◽  
Tumor Penetration ◽  
Dna Nanostructure ◽  
Promising Strategy

mproving the deep penetration of nanoparticles and realizing the combination of chemotherapy and immunotherapy have become a promising strategy for cancer treatment. Herein, nuclear-targeted tetrahedral DNA nanostructure (NLS-TDNs, NT) was...

Molecular Mechanism of Light-Induced Conformational Switching of the LOV Domain in Aureochrome-1

Biochemistry ◽  
2020 ◽  
Vol 59 (28) ◽  
pp. 2592-2601 ◽  
Author(s):  
Itsuki Kobayashi ◽  
Hiroto Nakajima ◽  
Osamu Hisatomi
Keyword(s):  
Molecular Mechanism ◽  
Lov Domain ◽  
Conformational Switching

scholarly journals Potent anti‐angiogenesis and anti‐tumour activity of pegaptanib‐loaded tetrahedral DNA nanostructure

2019 ◽  
Vol 52 (5) ◽  
Author(s):  
Xueping Xie ◽  
Yuxin Zhang ◽  
Wenjuan Ma ◽  
Xiaoru Shao ◽  
Yuxi Zhan ◽  
...  
Keyword(s):  
Dna Nanostructure ◽  
Anti Tumour Activity ◽  
Tumour Activity

Electrochemical Quantification ofEscherichia coliwith DNA Nanostructure

2015 ◽  
Vol 25 (25) ◽  
pp. 3840-3846 ◽  
Author(s):  
Marcella Giovanni ◽  
Magdiel Inggrid Setyawati ◽  
Chor Yong Tay ◽  
Hang Qian ◽  
Win Sen Kuan ◽  
...  
Keyword(s):  
Dna Nanostructure

Amperometric biosensor for microRNA based on the use of tetrahedral DNA nanostructure probes and guanine nanowire amplification

2017 ◽  
Vol 184 (8) ◽  
pp. 2597-2604 ◽  
Author(s):  
Yan Li Huang ◽  
Shi Mo ◽  
Zhong Feng Gao ◽  
Jing Rong Chen ◽  
Jing Lei Lei ◽  
...  
Keyword(s):  
Amperometric Biosensor ◽  
Dna Nanostructure
Sign in / Sign up

Export Citation Format

Share Document