TiL4-Coordinated Black Phosphorus Quantum Dots as an Efficient Contrast Agent for In Vivo Photoacoustic Imaging of Cancer

Small ◽  
2017 ◽  
Vol 13 (11) ◽  
pp. 1602896 ◽  
Author(s):  
Zhengbo Sun ◽  
Yuetao Zhao ◽  
Zhibin Li ◽  
Haodong Cui ◽  
Yayan Zhou ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Contrast Agent ◽  
Photoacoustic Imaging ◽  
Black Phosphorus ◽  
Black Phosphorus Quantum Dots

scholarly journals Folic Acid-Functionalized Black Phosphorus Quantum Dots for Targeted Chemo-Photothermal Combination Cancer Therapy

Pharmaceutics ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 242 ◽  
Author(s):  
Miaomiao Luo ◽  
Wei Cheng ◽  
Xiaowei Zeng ◽  
Lin Mei ◽  
Gan Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Quantum Dots ◽  
Folic Acid ◽  
Drug Delivery System ◽  
Delivery System ◽  
Black Phosphorus ◽  
Model Drug ◽  
Black Phosphorus Quantum Dots

Due to the inherent limitations, single chemo or photothermal therapies (PTT) are always inefficient. The combination of chemotherapy and PTT for the treatment of cancers has attracted a great interest during the past few years. As a photothermal agent, black phosphorus quantum dots (BPQDs) possess an excellent extinction coefficient, high photothermal conversion efficacy, and good biocompatibility. Herein, we developed a photo- and pH-sensitive nanoparticle based on BPQDs for targeted chemo-photothermal therapy. Doxorubicin (DOX) was employed as a model drug. This nanosystem displayed outstanding photothermal performance both in vitro and in vivo. Folic acid conjugation onto the surface endowed this system an excellent tumor-targeting effect, which was demonstrated by the cellular targeting assay. The BPQDs-based drug delivery system exhibited pH- and photo-responsive release properties, which could reduce the potential damage to normal cells. The in vitro cell viability study showed a synergistic effect in suppressing cancer cell proliferation. Therefore, this BPQDs-based drug delivery system has substantial potential for future clinical applications.

Phycocyanin-functionalized black phosphorus quantum dots enhance PDT/PTT therapy by inducing ROS and irreparable DNA damage

2021 ◽  
Author(s):  
Wanheng Zhang ◽  
Liting Yu ◽  
Yin Jiang ◽  
Changying Guo
Keyword(s):  
Dna Damage ◽  
Quantum Dots ◽  
Black Phosphorus ◽  
The Novel ◽  
Black Phosphorus Quantum Dots ◽  
Tumor Eradication

The novel phycocyanin (PC)-functionalized black phosphorus quantum dots (BPQDs) achieve synergistic photodynamic and photothermic activity by inducing massive ROS and irreparable DNA damage, resulting in increased apoptosis in vitro and tumor eradication in vivo.

Sequentially Triggered Delivery System of Black Phosphorus Quantum Dots with Surface Charge-Switching Ability for Precise Tumor Radiosensitization

ACS Nano ◽  
2018 ◽  
Vol 12 (12) ◽  
pp. 12401-12415 ◽  
Author(s):  
Leung Chan ◽  
Pan Gao ◽  
Wenhua Zhou ◽  
Chaoming Mei ◽  
Yanyu Huang ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Surface Charge ◽  
Delivery System ◽  
Black Phosphorus ◽  
Black Phosphorus Quantum Dots

scholarly journals Tea polyphenol modified, photothermal responsive and ROS generative black phosphorus quantum dots as nanoplatforms for promoting MRSA infected wounds healing in diabetic rats

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Shibo Xu ◽  
Linna Chang ◽  
Yanan Hu ◽  
Xingjun Zhao ◽  
Shuocheng Huang ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Wound Healing ◽  
Bacterial Infections ◽  
Photocatalytic Property ◽  
Black Phosphorus ◽  
Control Group ◽  
Ros Generation ◽  
Diabetic Patients ◽  
Photocatalytic Ability ◽  
Black Phosphorus Quantum Dots

Abstract Background Healing of MRSA (methicillin-resistant Staphylococcus aureus) infected deep burn wounds (MIDBW) in diabetic patients remains an obstacle but is a cutting-edge research problem in clinical science. Surgical debridement and continuous antibiotic use remain the primary clinical treatment for MIDBW. However, suboptimal pharmacokinetics and high doses of antibiotics often cause serious side effects such as fatal complications of drug-resistant bacterial infections. MRSA, which causes wound infection, is currently a bacterium of concern in diabetic wound healing. In more severe cases, it can even lead to amputation of the patient's limb. The development of bioactive nanomaterials that can promote infected wound healing is significant. Results The present work proposed a strategy of using EGCG (Epigallocatechin gallate) modified black phosphorus quantum dots (BPQDs) as therapeutic nanoplatforms for MIDBW to achieve the synergistic functions of NIR (near-infrared)-response, ROS-generation, sterilization, and promoting wound healing. The electron spin resonance results revealed that EGCG-BPQDs@H had a more vital photocatalytic ability to produce singlet oxygen than BPQDs@H. The inhibition results indicated an effective bactericidal rate of 88.6% against MRSA. Molecular biology analysis demonstrated that EGCG-BPQDs significantly upregulated CD31 nearly fourfold and basic fibroblast growth factor (bFGF) nearly twofold, which were beneficial for promoting the proliferation of vascular endothelial cells and skin epidermal cells. Under NIR irradiation, EGCG-BPQDs hydrogel (EGCG-BPQDs@H) treated MIDBW area could rapidly raise temperature up to 55 °C for sterilization. The MIBDW closure rate of rats after 21 days of treatment was 92.4%, much better than that of 61.1% of the control group. The engineered EGCG-BPQDs@H were found to promote MIDBW healing by triggering the PI3K/AKT and ERK1/2 signaling pathways, which could enhance cell proliferation and differentiation. In addition, intravenous circulation experiment showed good biocompatibility of EGCG-BPQDs@H. No significant damage to major organs was observed in rats. Conclusions The obtained results demonstrated that EGCG-BPQDs@H achieved the synergistic functions of photocatalytic property, photothermal effects and promoted wound healing, and are promising multifunctional nanoplatforms for MIDBW healing in diabetics. Graphical Abstract

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