scholarly journals Antiviral Agents: Correlation between Membrane Partitioning and Functional Activity in a Single Lipid Vesicle Assay Establishes Design Guidelines for Antiviral Peptides (Small 20/2015)

Small ◽  
2015 ◽  
Vol 11 (20) ◽  
pp. 2464-2464
Author(s):  
Joshua A. Jackman ◽  
Rathi Saravanan ◽  
Yibang Zhang ◽  
Seyed R. Tabaei ◽  
Nam-Joon Cho
Keyword(s):  
Functional Activity ◽  
Antiviral Agents ◽  
Design Guidelines ◽  
Lipid Vesicle ◽  
Membrane Partitioning ◽  
Antiviral Peptides

Correlation between Membrane Partitioning and Functional Activity in a Single Lipid Vesicle Assay Establishes Design Guidelines for Antiviral Peptides

Small ◽  
2015 ◽  
Vol 11 (20) ◽  
pp. 2372-2379 ◽  
Author(s):  
Joshua A. Jackman ◽  
Rathi Saravanan ◽  
Yibang Zhang ◽  
Seyed R. Tabaei ◽  
Nam-Joon Cho
Keyword(s):  
Functional Activity ◽  
Design Guidelines ◽  
Lipid Vesicle ◽  
Membrane Partitioning ◽  
Antiviral Peptides

Representing utility and deploying the body

2020 ◽  
Vol 43 ◽  
Author(s):  
David Spurrett
Keyword(s):  
Functional Activity ◽  
Degrees Of Freedom ◽  
The Body ◽  
Target Article ◽  
Processing Demands ◽  
The Many

Abstract Comprehensive accounts of resource-rational attempts to maximise utility shouldn't ignore the demands of constructing utility representations. This can be onerous when, as in humans, there are many rewarding modalities. Another thing best not ignored is the processing demands of making functional activity out of the many degrees of freedom of a body. The target article is almost silent on both.

New chlorinated daphnane diterpenoids orthoester from Trigonostemon cherrieri as potent antiviral agents

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
M Bourjot ◽  
PM Allard ◽  
MT Martin ◽  
P Leyssen ◽  
F Guéritte ◽  
...  
Keyword(s):  
Antiviral Agents

Plasma Derived von Willebrand Factor Preparations: Collagen Binding and Ristocetin Cofactor Activities

1997 ◽  
Vol 78 (02) ◽  
pp. 930-933 ◽  
Author(s):  
Ping Chang ◽  
D L Aronson
Keyword(s):  
Von Willebrand Factor ◽  
Functional Activity ◽  
Binding Activity ◽  
Collagen Binding ◽  
Binding Function ◽  
Cofactor Activity ◽  
Von Willebrand ◽  
Willebrand Factor ◽  
Ristocetin Cofactor ◽  
Ristocetin Cofactor Activity

SummaryFive plasma preparations (11 lots) used in the treatment of von Willebrand’s disease (vWD) were evaluated. The collagen binding function of von Willebrand factor (vWF) containing preparations was compared with the ristocetin cofactor activity and the vWF antigen. Some preparations have higher ratio of functional activity (ristocetin cofactor and collagen binding) relative to the antigen than is found in normal plasma. The ristocetin cofactor activity and the collagen binding activity are tightly correlated (r = .95). Ultracentrifugal (UCF) analysis was used to compare the size distribution of vWf antigen, ristocetin cofactor and collagen binding activity. The sedimentation of all of the vWF parameters in the plasma products was slower than in plasma. In plasma products the ristocetin cofactor activity sediments the most rapidly, the collagen binding activity is slower and the antigen the slowest. The collagen/antigen ratio decreases with decreasing vWF size. Assignment of potency to vWF containing preparations utilizing the collagen binding activity may be more precise and as accurate as with the traditional ristocetin cofactor assay.

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