Intercellular Transport of Nanomaterials is Mediated by Membrane Nanotubes In Vivo

Small ◽  
2016 ◽  
Vol 12 (14) ◽  
pp. 1882-1890 ◽  
Author(s):  
Markus Rehberg ◽  
Katharina Nekolla ◽  
Sabine Sellner ◽  
Marc Praetner ◽  
Karina Mildner ◽  
...  
Keyword(s):  
Intercellular Transport ◽  
Membrane Nanotubes

Nanomedicine: Intercellular Transport of Nanomaterials is Mediated by Membrane Nanotubes In Vivo (Small 14/2016)

Small ◽  
2016 ◽  
Vol 12 (14) ◽  
pp. 1818-1818
Author(s):  
Markus Rehberg ◽  
Katharina Nekolla ◽  
Sabine Sellner ◽  
Marc Praetner ◽  
Karina Mildner ◽  
...  
Keyword(s):  
Intercellular Transport ◽  
Membrane Nanotubes

scholarly journals VP22-mediated intercellular transport of p53 in hepatoma cells in vitro and in vivo

2002 ◽  
Vol 9 (6) ◽  
pp. 489-496 ◽  
Author(s):  
Lars Zender ◽  
Florian Kühnel ◽  
Reiner Köck ◽  
Michael Manns ◽  
Stefan Kubicka
Keyword(s):  
Hepatoma Cells ◽  
Intercellular Transport

Cytoplasmic streaming and transport in the characean alga Nitella

1980 ◽  
Vol 58 (7) ◽  
pp. 786-796 ◽  
Author(s):  
N. Strömgren Allen
Keyword(s):  
Light Microscopy ◽  
Actin Filaments ◽  
Cytoplasmic Streaming ◽  
Three Dimensional ◽  
Differential Interference Contrast ◽  
Intercellular Transport ◽  
Cryoprotective Agents ◽  
Myosin Filaments ◽  
Microscopy Techniques

Plasmodesmata were recorded in vivo in Nitella furcata using polarization and differential interference-contrast light microscopy, techniques that could prove useful for further physiological experimentation on intercellular transport in characean cells.Freeze-fractured, deep-etch replicas of Nitella endoplasm were prepared without the use of cryoprotective agents. The endoplasm, in which rapid cytoplasmic streaming occurs, contains intricate three-dimensional networks of filaments of which two prominent size classes are characterized: 7- to 8-nm putative actin filaments and 4- to 5-nm putative myosin filaments. It is quite likely that the putative actin filaments are components of the endoplasmic filaments, and that these filaments interacting with the 4- to 5-nm filaments produce the motive force generating the observed cytoplasmic streaming.

scholarly journals Cutting Edge: Membrane Nanotubes In Vivo: A Feature of MHC Class II+ Cells in the Mouse Cornea

2008 ◽  
Vol 180 (9) ◽  
pp. 5779-5783 ◽  
Author(s):  
Holly R. Chinnery ◽  
Eric Pearlman ◽  
Paul G. McMenamin
Keyword(s):  
Mhc Class Ii ◽  
Class Ii ◽  
Cutting Edge ◽  
Membrane Nanotubes

scholarly journals Long-distance relationships: do membrane nanotubes regulate cell–cell communication and disease progression?

2013 ◽  
Vol 24 (8) ◽  
pp. 1095-1098 ◽  
Author(s):  
Nathan M. Sherer
Keyword(s):  
Calcium Signaling ◽  
Electrical Coupling ◽  
Cell Communication ◽  
Tunneling Nanotubes ◽  
Long Distance ◽  
Membrane Nanotubes ◽  
Pathogenic Agents ◽  
Key Questions ◽  
Cell Cell

Metazoan cells rapidly exchange signals at tight cell–cell interfaces, including synapses and gap junctions. Advances in imaging recently exposed a third mode of intercellular cross-talk mediated by thin, actin-containing membrane extensions broadly known as “membrane” or “tunneling” nanotubes. An explosion of research suggests diverse functions for nanotubular superhighways, including cell–cell electrical coupling, calcium signaling, small-molecule exchange, and, remarkably, the transfer of bulky cargoes, including organelles or pathogenic agents. Despite great enthusiasm for all things nanotubular and their potential roles in cell signaling and pathogenesis, key questions remain regarding the mechanisms by which these structures regulate directional cell–cell exchange; how these linkages are formed and between which cells and, critically, whether nanotubes are as prevalent in vivo as they appear to be in the incubator.

scholarly journals Membrane nanotubes are ancient machinery for cell-to-cell communication and transport. Their interference with the immune system

2021 ◽  
Author(s):  
János Matkó ◽  
Eszter Angéla Tóth
Keyword(s):  
Current Knowledge ◽  
Cell Communication ◽  
Super Resolution ◽  
Cell Types ◽  
Bacterial Strains ◽  
Membrane Nanotubes ◽  
Long Time ◽  
Cross Dressing ◽  
Cellular Immune

AbstractNanotubular connections between mammalian cell types came into the focus only two decades ago, when “live cell super-resolution imaging” was introduced. Observations of these long-time overlooked structures led to understanding mechanisms of their growth/withdrawal and exploring some key genetic and signaling factors behind their formation. Unbelievable level of multiple supportive collaboration between tumor cells undergoing cytotoxic chemotherapy, cross-feeding” between independent bacterial strains or “cross-dressing” collaboration of immune cells promoting cellular immune response, all via nanotubes, have been explored recently. Key factors and "calling signals" determining the spatial directionality of their growth and their overall in vivo significance, however, still remained debated. Interestingly, prokaryotes, including even ancient archaebacteria, also seem to use such NT connections for intercellular communication. Herein, we will give a brief overview of current knowledge of membrane nanotubes and depict a simple model about their possible “historical role”.

Fluorescent nanodiamond as a probe for the intercellular transport of proteins in vivo

Biomaterials ◽  
2013 ◽  
Vol 34 (33) ◽  
pp. 8352-8360 ◽  
Author(s):  
Yung Kuo ◽  
Tsung-Yuan Hsu ◽  
Yi-Chun Wu ◽  
Huan-Cheng Chang
Keyword(s):  
Intercellular Transport

Fine Structural Changes in the Microvasculature of the Mouse Pinna: Aging and Radiation Injury

1974 ◽  
Vol 32 ◽  
pp. 54-55
Author(s):  
S. Phyllis Steamer ◽  
Rosemarie L. Devine
Keyword(s):  
Structural Changes ◽  
Radiation Treatment ◽  
Arterial Stenosis ◽  
Ultrastructural Changes ◽  
Vascular Effects ◽  
Microvascular Changes ◽  
Surrounding Connective Tissue ◽  
Fission Neutrons ◽  
Total Body

The importance of radiation damage to the skin and its vasculature was recognized by the early radiologists. In more recent studies, vascular effects were shown to involve the endothelium as well as the surrounding connective tissue. Microvascular changes in the mouse pinna were studied in vivo and recorded photographically over a period of 12-18 months. Radiation treatment at 110 days of age was total body exposure to either 240 rad fission neutrons or 855 rad 60Co gamma rays. After in vivo observations in control and irradiated mice, animals were sacrificed for examination of changes in vascular fine structure. Vessels were selected from regions of specific interest that had been identified on photomicrographs. Prominent ultrastructural changes can be attributed to aging as well as to radiation treatment. Of principal concern were determinations of ultrastructural changes associated with venous dilatations, segmental arterial stenosis and tortuosities of both veins and arteries, effects that had been identified on the basis of light microscopic observations. Tortuosities and irregularly dilated vein segments were related to both aging and radiation changes but arterial stenosis was observed only in irradiated animals.

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