Magnetoresponsive Virus-Mimetic Nanocapsules with Dual Heat-Triggered Sequential-Infected Multiple Drug-Delivery Approach for Combinatorial Tumor Therapy

Small ◽  
2015 ◽  
Vol 11 (20) ◽  
pp. 2417-2428 ◽  
Author(s):  
Jen-Hung Fang ◽  
Yun-Ting Lee ◽  
Wen-Hsuan Chiang ◽  
Shang-Hsiu Hu
Keyword(s):  
Drug Delivery ◽  
Tumor Therapy ◽  
Multiple Drug ◽  
Multiple Drug Delivery ◽  
Delivery Approach

Multiple drug delivery hydrogel system for spinal cord injury repair strategies

2012 ◽  
Vol 159 (2) ◽  
pp. 271-280 ◽  
Author(s):  
Giuseppe Perale ◽  
Filippo Rossi ◽  
Marco Santoro ◽  
Marco Peviani ◽  
Simonetta Papa ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Multiple Drug ◽  
Injury Repair ◽  
Cord Injury ◽  
Multiple Drug Delivery ◽  
Hydrogel System

Application of Hydrogel Biocomposites for Multiple Drug Delivery

2017 ◽  
pp. 139-165 ◽  
Author(s):  
S.J. Owonubi ◽  
S.C. Agwuncha ◽  
E. Mukwevho ◽  
B.A. Aderibigbe ◽  
E.R. Sadiku ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Multiple Drug ◽  
Multiple Drug Delivery

scholarly journals Design of a multiple drug delivery system directed at periodontitis

Biomaterials ◽  
2013 ◽  
Vol 34 (34) ◽  
pp. 8835-8842 ◽  
Author(s):  
Sharath C. Sundararaj ◽  
Mark V. Thomas ◽  
Rebecca Peyyala ◽  
Thomas D. Dziubla ◽  
David A. Puleo
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Multiple Drug ◽  
Multiple Drug Delivery

A self-assembled albumin based multiple drug delivery nanosystem to overcome multidrug resistance

RSC Advances ◽  
2015 ◽  
Vol 5 (9) ◽  
pp. 6807-6814 ◽  
Author(s):  
Bin Chen ◽  
Cong Wu ◽  
Ren-Xi Zhuo ◽  
Si-Xue Cheng
Keyword(s):  
Drug Delivery ◽  
Drug Resistance ◽  
Multidrug Resistance ◽  
Drug Delivery System ◽  
Delivery System ◽  
Multiple Drug ◽  
Self Assembled ◽  
Multiple Drug Delivery

A self-assembled nano-sized albumin based drug delivery system co-loaded with an anti-tumor drug and a drug resistance inhibitor has promising applications in overcoming multidrug resistance (MDR).

Development of a multiple-drug delivery implant for intraocular management of proliferative vitreoretinopathy

1998 ◽  
Vol 55 (2-3) ◽  
pp. 281-295 ◽  
Author(s):  
Tianhong Zhou ◽  
Hilel Lewis ◽  
Robert E. Foster ◽  
Steven P. Schwendeman
Keyword(s):  
Drug Delivery ◽  
Proliferative Vitreoretinopathy ◽  
Multiple Drug ◽  
Multiple Drug Delivery

Sialic acid–targeted drug delivery and imaging system for pH- and glutathione-triggered multiple anticancer drug release and enhanced oxidative stress

2020 ◽  
Vol 35 (3) ◽  
pp. 254-269
Author(s):  
Licong Peng ◽  
Xianwu Zeng ◽  
Qianqian Qi ◽  
Hailiang Zhang ◽  
Jinping Fu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Drug Delivery ◽  
Quantum Dots ◽  
Photodynamic Therapy ◽  
Sialic Acid ◽  
Multiple Drug ◽  
Emission Computed Tomography ◽  
Light Conditions ◽  
Multiple Drug Delivery

The emergence of multiple drug delivery systems can solve the disadvantages of single-drug therapy, such as high dose and easy generation of drug resistance. Here, we designed a sialic acid–targeted dextran-mercaptopurine prodrug linked by carbonyl vinyl sulfide for coordinate ZnO quantum dots to achieve multiple drug delivery (doxorubicin, 5-fluorouracil, 6-mercaptopurine), which can be released under the trigger of pH and glutathione. To enhance the antitumor effect, we used inorganic photosensitizer CdSe quantum dots to achieve photodynamic therapy, which can produce cytotoxic reactive oxygen species (hydroxyl radicals) under light conditions. Notably, we found that glutathione is consumed by the delivery of 6-mercaptopurine. It is able to efficiently amplify intracellular oxidative stress via increasing •OH generation. After chelating 99mTc4+ radioisotopes by diethylenetriamine pentaacetic acid, the drug delivery system could be tracked under in vivo single-photon emission computed tomography imaging. The results showed that the phenylboronic acid targeting substance can specifically recognize sialic acid, so that the drug system has a good accumulation in the tumor site, which can better increase the therapeutic effect. Compared to free doxorubicin, the drug system can reduce the IC50 value of cells 4.4-fold under light conditions and significantly inhibit tumor growth in vivo. These data indicate that the sialic acid–targeted nanomedicine system has achieved ideal antitumor effects and apparent photodynamic therapy effects and has broad application prospects.

Multiple Drug Delivery from Mesoporous Coating Realizing Combination Therapy for Bare Metal Stents

Langmuir ◽  
2019 ◽  
Vol 35 (8) ◽  
pp. 3126-3133 ◽  
Author(s):  
Qi Wang ◽  
Shuang Long Hu ◽  
Ying Ben Wu ◽  
Qian Niu ◽  
Yang Yang Huang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Combination Therapy ◽  
Bare Metal Stents ◽  
Metal Stents ◽  
Multiple Drug ◽  
Bare Metal ◽  
Multiple Drug Delivery

Photoresponsive Protein-Graphene-Protein Hybrid Capsules with Dual Targeted Heat-Triggered Drug Delivery Approach for Enhanced Tumor Therapy

2014 ◽  
Vol 24 (26) ◽  
pp. 4144-4155 ◽  
Author(s):  
Shang-Hsiu Hu ◽  
Ren-Hong Fang ◽  
Yu-Wei Chen ◽  
Bang-Jie Liao ◽  
I-Wei Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Therapy ◽  
Delivery Approach
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