Detection of a Single Nucleotide Polymorphism Using Single-Walled Carbon-Nanotube Near-Infrared Fluorescence

Small ◽  
2010 ◽  
Vol 6 (1) ◽  
pp. 40-43 ◽  
Author(s):  
Esther S. Jeng ◽  
John D. Nelson ◽  
Kristala L. J. Prather ◽  
Michael S. Strano
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Carbon Nanotube ◽  
Near Infrared ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Single Walled Carbon Nanotube ◽  
Near Infrared Fluorescence ◽  
Single Walled Carbon

scholarly journals Single Nucleotide Polymorphism Detection Using Au-Decorated Single-Walled Carbon Nanotube Field Effect Transistors

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Keum-Ju Lee ◽  
Hye-Mi So ◽  
Byoung-Kye Kim ◽  
Do Won Kim ◽  
Jee-Hwan Jang ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Field Effect Transistors ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide Polymorphism Detection ◽  
Single Nucleotide ◽  
Single Walled Carbon Nanotube ◽  
Single Walled Carbon ◽  
Au Clusters ◽  
Polymorphism Detection ◽  
Au Cluster

We demonstrate that Au-cluster-decorated single-walled carbon nanotubes (SWNTs) may be used to discriminate single nucleotide polymorphism (SNP). Nanoscale Au clusters were formed on the side walls of carbon nanotubes in a transistor geometry using electrochemical deposition. The effect of Au cluster decoration appeared as hole doping when electrical transport characteristics were examined. Thiolated single-stranded probe peptide nucleic acid (PNA) was successfully immobilized on Au clusters decorating single-walled carbon nanotube field-effect transistors (SWNT-FETs), resulting in a conductance decrease that could be explained by a decrease in Au work function upon adsorption of thiolated PNA. Although a target single-stranded DNA (ssDNA) with a single mismatch did not cause any change in electrical conductance, a clear decrease in conductance was observed with matched ssDNA, thereby showing the possibility of SNP (single nucleotide polymorphism) detection using Au-cluster-decorated SWNT-FETs. However, a power to discriminate SNP target is lost in high ionic environment. We can conclude that observed SNP discrimination in low ionic environment is due to the hampered binding of SNP target on nanoscale surfaces in low ionic conditions.

(Invited) In Vivo Analyte Detection Via Single-Walled Carbon Nanotube Near-Infrared Fluorescence

2020 ◽  
Vol MA2020-02 (67) ◽  
pp. 3417-3417
Author(s):  
Ryan M. Williams ◽  
Jackson Harvey ◽  
Thomas Galassi ◽  
Daniel A. Heller
Keyword(s):  
Carbon Nanotube ◽  
Near Infrared ◽  
Single Walled Carbon Nanotube ◽  
Near Infrared Fluorescence ◽  
Single Walled Carbon ◽  
Analyte Detection

(Invited) In Vivo Analyte Detection Via Single-Walled Carbon Nanotube Near-Infrared Fluorescence

2020 ◽  
Vol MA2020-01 (6) ◽  
pp. 638-638
Author(s):  
Ryan M. Williams ◽  
Jackson Harvey ◽  
Thomas Galassi ◽  
Daniel A. Heller
Keyword(s):  
Carbon Nanotube ◽  
Near Infrared ◽  
Single Walled Carbon Nanotube ◽  
Near Infrared Fluorescence ◽  
Single Walled Carbon ◽  
Analyte Detection

A Luciferase/Single-Walled Carbon Nanotube Conjugate for Near-Infrared Fluorescent Detection of Cellular ATP

2010 ◽  
Vol 122 (8) ◽  
pp. 1498-1501 ◽  
Author(s):  
Jong-Ho Kim ◽  
Jin-Ho Ahn ◽  
Paul W. Barone ◽  
Hong Jin ◽  
Jingqing Zhang ◽  
...  
Keyword(s):  
Carbon Nanotube ◽  
Near Infrared ◽  
Fluorescent Detection ◽  
Single Walled Carbon Nanotube ◽  
Single Walled Carbon
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