scholarly journals Preparation of Monodisperse Biodegradable Polymer Microparticles Using a Microfluidic Flow‐Focusing Device for Controlled Drug Delivery

Small ◽  
2009 ◽  
Vol 5 (13) ◽  
pp. 1575-1581 ◽  
Author(s):  
Qiaobing Xu ◽  
Michinao Hashimoto ◽  
Tram T. Dang ◽  
Todd Hoare ◽  
Daniel S. Kohane ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Biodegradable Polymer ◽  
Controlled Drug Delivery ◽  
Flow Focusing ◽  
Microfluidic Flow ◽  
Polymer Microparticles

scholarly journals Surfactant-Laden Janus Droplets with Tunable Morphologies and Enhanced Stability for Fabricating Lens-Shaped Polymeric Microparticles

Micromachines ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 29
Author(s):  
Siyuan Xu ◽  
Takasi Nisisako
Keyword(s):  
Silicone Oil ◽  
Flow Focusing ◽  
Acrylate Monomer ◽  
Microfluidic Flow ◽  
Planar Convex ◽  
Improved Stability ◽  
Polymeric Microparticles ◽  
Glass Chip ◽  
Polymer Microparticles ◽  
Enhanced Stability

Janus droplets can function as excellent templates for fabricating physically and chemically anisotropic particles. Here, we report new surfactant-laden Janus droplets with curvature controllability and enhanced stability against coalescence, suitable for fabricating shape-anisotropic polymer microparticles. Using a microfluidic flow-focusing device on a glass chip, nanoliter-sized biphasic droplets, comprising an acrylate monomer segment and a silicone-oil (SO) segment containing a surfactant, were produced in a co-flowing aqueous polyvinyl alcohol (PVA) solution. At equilibrium, the droplets formed a Janus geometry based on the minimization of interfacial energy, and each of the two Janus segments were uniform in size with coefficient-of-variation values below 3%. By varying the concentration of the surfactant in the SO phase, the curvature of the interface between the two lobes could be shifted among concave, planar, and convex shapes. In addition, the Janus droplets exhibited significantly improved stability against coalescence compared with previously reported Janus droplets carrying no surfactant that coalesced rapidly. Finally, via off-chip photopolymerization, concave-convex, planar-convex, and biconvex lens-shaped particles were fabricated.

Microfluidic Formation of Hydrogel Microparticles for Drug Delivery

2010 ◽  
Author(s):  
Amy Betz ◽  
Hanwei Zhang ◽  
Weiliam Chen ◽  
Daniel Attinger
Keyword(s):  
Drug Delivery ◽  
Microfluidic Chip ◽  
Flow Focusing ◽  
Traditional Methods ◽  
Hydrogel Microparticles ◽  
Microfluidic Flow ◽  
Drug Delivery Applications ◽  
Unique Composition

Creating monodispersed hydrogel microparticles is advantageous for drug delivery applications. We explore microfluidic flow focusing as a method for generating such particles. Our hydrogel has a unique composition that makes it biodegradable and mechanically strong. We designed and manufactured a polymer microfluidic chip that mixes three viscous precursor solutions and generates a steady stream of microparticles from that solution. We found that microfluidic flow focusing produce particle with a coefficient of variance around 9%; this was a four times improvement over traditional methods.

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