Mindfulness-based program for stress reduction in infertile women: Randomized controlled trial

2018 ◽  
Vol 35 (1) ◽  
pp. 49-58 ◽  
Author(s):  
Simone F. Nery ◽  
Sara P.C. Paiva ◽  
Érica L. Vieira ◽  
Andressa B. Barbosa ◽  
Edna M. Sant'Anna ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Stress Reduction ◽  
Controlled Trial ◽  
Infertile Women ◽  
Randomized Controlled

scholarly journals A Randomized Controlled Trial of the Effects of Mindfulness-Based Stress Reduction (MBSR[BC]) on Levels of Inflammatory Biomarkers Among Recovering Breast Cancer Survivors

2017 ◽  
Vol 19 (4) ◽  
pp. 456-464 ◽  
Author(s):  
Richard R. Reich ◽  
Cecile A. Lengacher ◽  
Thomas W. Klein ◽  
Cathy Newton ◽  
Steve Shivers ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Randomized Controlled Trial ◽  
Stress Reduction ◽  
Tumor Necrosis ◽  
Breast Cancer Survivors ◽  
Controlled Trial ◽  
Randomized Controlled ◽  
Cytokine Levels ◽  
Tgf Β1 ◽  
Necrosis Factor

Purpose: The purpose of this substudy of a large randomized controlled trial was to evaluate the efficacy of the Mindfulness-Based Stress Reduction (Breast Cancer) (MBSR[BC]) program compared to usual care (UC) in normalizing blood levels of pro-inflammatory cytokines among breast cancer survivors (BCS). Method: A total of 322 BCS were randomized to either a 6-week MBSR(BC) program or a UC. At baseline and 6 and 12 weeks, 10 ml of venous blood and demographic and clinical data were collected and/or updated. Plasma cytokines (interleukin [IL]-1β, IL-6, IL-10, tumor necrosis factor [TNF] α, transforming growth factor [TGF] β1, soluble tumor necrosis factor receptor [sTNFR] 1) were assayed. Linear mixed models were used to assess cytokine levels across three time points (baseline and 6 and 12 weeks) by group (MBSR[BC] vs. UC). Results: Of the six measured cytokines, three were nondetectable at rates greater than 50% (IL-10, IL-1β, TGF-β1) and, because of overall low prevalence, were not analyzed further. For the remaining cytokines (TNFα, IL-6, sTNFR1), results showed that TNFα and IL-6 increased during the follow-up period (between 6 and 12 weeks) rather than during the MBSR(BC) training period (between baseline and 6 weeks), while sTNFR1 levels did not change significantly across the 12-week period. Conclusions: Study results suggest that MBSR(BC) affects cytokine levels in BCS, mainly with increases in TNFα and IL-6. The data further suggest that B-cell modulation may be a part of immune recovery during breast cancer management and that increases in TNFα and IL-6 may be markers for MBSR(BC)-related recovery.

scholarly journals Randomized Controlled Trial of Preconception Interventions in Infertile Women With Polycystic Ovary Syndrome

2015 ◽  
Vol 100 (11) ◽  
pp. 4048-4058 ◽  
Author(s):  
Richard S. Legro ◽  
William C. Dodson ◽  
Penny M. Kris-Etherton ◽  
Allen R. Kunselman ◽  
Christy M. Stetter ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Controlled Trial ◽  
Ovary Syndrome ◽  
Infertile Women ◽  
Randomized Controlled
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