scholarly journals Expression of a Distinct Set of Chemokine Receptors in Adipose Tissue‐Derived Stem Cells is Responsible for In Vitro Migration Toward Chemokines Appearing in the Major Pelvic Ganglion Following Cavernous Nerve Injury

10.1002/sm2.1 ◽  
2013 ◽  
Vol 1 (1) ◽  
pp. 3-15 ◽  
Author(s):  
Maarten Albersen ◽  
Joost Berkers ◽  
Philip Dekoninck ◽  
Jan Deprest ◽  
Tom F. Lue ◽  
...  
Keyword(s):  
Stem Cells ◽  
Adipose Tissue ◽  
Nerve Injury ◽  
Chemokine Receptors ◽  
Pelvic Ganglion ◽  
Cavernous Nerve ◽  
Major Pelvic Ganglion ◽  
Cavernous Nerve Injury

scholarly journals Neurotrophic Effect of Adipose Tissue-Derived Stem Cells on Erectile Function Recovery by Pigment Epithelium-Derived Factor Secretion in a Rat Model of Cavernous Nerve Injury

2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Xin Chen ◽  
Qiyun Yang ◽  
Tao Zheng ◽  
Jun Bian ◽  
Xiangzhou Sun ◽  
...  
Keyword(s):  
Stem Cells ◽  
Adipose Tissue ◽  
Nerve Injury ◽  
Erectile Function ◽  
Pigment Epithelium ◽  
Intracavernous Injection ◽  
Cavernous Nerve ◽  
Pigment Epithelium Derived Factor ◽  
Cavernous Nerve Injury

The paracrine effect is the major mechanism of stem cell therapy. However, the details of the effect’s mechanism remain unknown. The aim of this study is to investigate whether adipose tissue-derived stem cells (ADSCs) can ameliorate cavernous nerve injury-induced erectile dysfunction (CNIED) rats and to determine its mechanism. Twenty-eight days after intracavernous injection of 5-ethynyl-2-deoxyuridine- (EdU-) labeled ADSCs, the erectile function of all the rats was evaluated by intracavernosal pressure (ICP). The ADSCs steadily secreted detectable pigment epithelium-derived factor (PEDF)in vitro. The expression of PEDF increased in the penis of the bilateral cavernous nerve injury (BCNI) group for 14 days and then gradually decreased. On day 28 after the intracavernous injection, the ADSCs group exhibited a significantly increased ICP compared with the phosphate buffered saline- (PBS-) treated group. Moreover, the neuronal nitric oxide synthase (nNOS) and S100 expression in penile dorsal nerves and the smooth muscle content to collagen ratio in penile tissues significantly increased. Furthermore, elevated PEDF, p-Akt, and p-eNOS were identified in the ADSCs group. This study demonstrated that intracavernous injection of ADSCs improved erectile function, repaired the nerve, and corrected penile fibrosis. One potential mechanism is the PEDF secretion of ADSCs and subsequent PI3K/Akt pathway activation.

MP43-10 CAVERNOUS NERVE INJURY INDUCED TEMPORAL INCREASE IN NEUROINFLAMMATION AND CYTOKINE INDUCTION IN THE MAJOR PELVIC GANGLION OF THE RAT

2014 ◽  
Vol 191 (4S) ◽  
Author(s):  
Johanna Hannan ◽  
Emmanuel Weyne ◽  
Maarten Albersen ◽  
Xiaopu Liu ◽  
Fabio Castiglione ◽  
...  
Keyword(s):  
Nerve Injury ◽  
Pelvic Ganglion ◽  
Cavernous Nerve ◽  
Cytokine Induction ◽  
Major Pelvic Ganglion ◽  
Cavernous Nerve Injury
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