Targeting Neuroblastoma by Limonoids from the Underutilized Fruits of Xylocarpus granatum

2022 ◽  
Vol 7 (2) ◽  
Author(s):  
Kiran Munipalle ◽  
Vamsi Krishna Kommalapati ◽  
Hemendra Kumar Patel ◽  
Bolatito Eunice Olanipekun ◽  
Anjana Devi Tangutur ◽  
...  
Keyword(s):  
Planta Medica ◽  
2006 ◽  
Vol 72 (11) ◽  
Author(s):  
H Wangensteen ◽  
GM Duong ◽  
M Alamgir ◽  
M Sarder ◽  
AB Samuelsen ◽  
...  
Keyword(s):  

2020 ◽  
Vol 11 (1) ◽  
pp. 1-10
Author(s):  
Agus Putra A. Samad ◽  
Pitri Agustina ◽  
Mus Herri

Langsa merupakan salah satu kota pesisir Aceh yang memiliki kawasan mangrove yang  sangat  potensial.  Kota  ini  memiliki  panjang  garis  pantai  16  km dengan luas kawasan mangrove sebesar 7.837 Ha. Keberadaan mangrove di wilayah ini menjadi aset strategis untuk dikembangkan menjadi basis kegiatan ekonomi untuk memakmurkan masyarakat dan meningkatkan pendapatan  asli  daerah. Tujuan utama penelitian ini adalah untuk melestarikan potensi sumberdaya ekosistem mangrove yang ada di Kota Langsa agar dapat memberikan fungsi ekologis dan ekonomis secara berkesinambungan kepada masyarakat disekitarnya. Kajian ini dilakukan menggunakan metode survei, analisa laboratorium dan observasi lapangan. Hasil pengamatan terhadap komposisi jenis tumbuhan yang terdapat di ekosistem mangrove menunjukkan 8 jenis tumbuhan mangrove yaitu: jenis Avicennia lanata, Avicennia marina, Bruguiera gymnorrhiza, Bruguiera parviflora, Rhizophora apiculata, Rhizophora  mucronata, Sonneratia Caseolaris dan Xylocarpus granatum. Nilai rata-rata parameter kualitas air di ekosistem mangrove secara beturut-turut adalah DO (6.3 ppm),salinitas (27 ‰), pH tanah dasar (6.0), pH tanah permukaan (5.08), pH air (7.33), suhu (30 oC) dan kecerahan (5 m).  Perhitungan terhadap nilai manfaat ekosistem mangrove meliputi: 1) Nilai manfaat langsung perikanan tangkap: Rp. 8.710.000.000 per tahun, 2) Nilai manfaat budidaya tambak: Rp. 93.940.000.000,- per tahun, 3) Nilai penahan abrasi dan banjir: Rp. 300.000.000,- per hektar per tahun, 4) Nilai sebagai penyediaan unsur hara: Rp. 28.634.000,- per tahun, 5) Nilai manfaat pilihan: Rp. 210.000.000,- per tahun dan 6) Nilai manfaat keberadaan: Rp. 1.464.493.000,- per tahun.  Nilai keberadaan ekosistem mangrove yang dinilai adalah Nilai Keaslian = 70 % (lebih dari asli), Nilai Keindahan Alam = 74 % (lebih dari indah), Nilai Kenyamanan = 66% (kondisi lebih dari nyaman),  dan Nilai Aspirasi masyarakat = 98 % (sangat didukung masyarakat). Alternatif  pengelolaan  dan  pemanfaatan  ekosistem  mangrove  yang diperkirakan cocok secara ekonomi dan ekologis terdiri dari beberapa kegiatan pilihan yaitu budidaya ikan, udang, tiram dan kepiting, budidaya ikan kerapu dan kakap, pengolahan buah dan daun mangrove, dan pengembangan obyek wisata.


Author(s):  
Kismanto Koroy ◽  
Sandra Hi. Muhammad ◽  
Nurafni Nurafni ◽  
Nurti Boy

ABSTRACTMangroves are one of the most important natural resources in coastal areas. Availability of various types of food that are on ecosystems is already making its presence as a local nursery, where searching for eating and also serve as a regional tourist ecosystem of mangrove. In use as Regional tourist mangrove need to attention the condition of the physical environment and the distribution pattern of zoning. Research is carried out in the month October to November 2019 in the village of Juanga Regency island of Morotai. Data zoning mangrove using the method of the combination is to combine the methods of plots to track transects, to determine the four stations of observation of each respective stations and each station is divided into three zones: zone front, zone of middle and zone back starting from the point of the outermost growth of types of mangrove constituent primary to the point of transition between sea and land. The research results of the study found 5 types of mangroves namely Rhizophora mucronata, Ceriops decandra, Rhizophora apiculata, Xylocarpus granatum and Sonneratia alba. The distribution of zoning patterns in the front zones of station I and the middle zone is dominated by Rhizophora mucronata and Rhizophora apiculata types, the rear zone is dominated by Ceriops decandra. Station II front zone is dominated by Sonneratia alba, middle zone (Rhizophora mucronata), rear zone (Ceriops decandra). At station III the front zone (Rhizophora apiculata), the middle zone and the rear zone (Ceriops decandra) while at station IV the front zone, the middle zone and the rear zone are dominated by the Ceriops decandra type.


F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 63 ◽  
Author(s):  
Gina Saptiani ◽  
A. Syafei Sidik ◽  
Fikri Ardhani

Background: Xylocarpus granatum has been used as a medicinal plant by coastal communities, which may indicate that this plant is a potential source of pharmaceuticals. Methods: Xylocarpus granatum leaf extract was tested as an antimicrobial agent for pathogens infecting tiger shrimp post-larvae. Of the treatments applied to the post-larvae, 25 were crudely extracted with ethanol, distilled water, and seawater solvent given by immersion. Vibrio harveyi and Saprolegnia sp. were microbial species used for the test. Results: X. granatum extract had the potential to inhibit V. harveyi and Saprolegnia sp., reducing infection and improving the survival of shrimp. Shrimp soaked with X. granatum extract had a total Vibrio count ranging from 14.67x103 to 22.67x103 CFU/ml. The survival rate of shrimp was recorded as 53.33% to 78.67% and 54.67% to 76.00% due to V. harveyi, and Saprolegnia sp infection, respectively. The relative percentage of the survival of shrimp protected from V. harveyi and Saprolegnia sp infection in treatments compared to negative controls ranged from 40.61% to 72.89% and 35.84% to 66.12%, respectively. Conclusions: Leaf extracts of X. granatum, which might have better antimicrobial activities to prevent tiger shrimp from pathogenetic infection, were consecutively extracted ethanol at 800-1,000 ppm, distilled water at 800-1,000 ppm, and seawater at 1,000 ppm.


ChemInform ◽  
2004 ◽  
Vol 35 (40) ◽  
Author(s):  
Jun Wu ◽  
Qiang Xiao ◽  
Jianshe Huang ◽  
Zhihui Xiao ◽  
Shuhua Qi ◽  
...  

Author(s):  
Irmanida Batubara ◽  
Maily Mustofa ◽  
Wulan Tri Wahyuni ◽  
Kilala Tilaar ◽  
Waras Nurcholis ◽  
...  

Xylocarpus granatum is mangrove plant that traditionally used as face powder in Central Sulawesi, Indonesia which related to antioxidant, antiglycation and tyrosinase inhibition activities. This study aimed to evaluate the potency of X. granatum as a tyrosinase inhibitor, antiglycation, and antioxidant. The leaves, stem, stem bark, fruit flesh, fruit peel, and kernel of X. granatum were extracted using ethanol then their tyrosinase inhibition, antiglycation, and antioxidant were evaluated. Tyrosinase inhibition activity was evaluated using in vitro assay with L-tyrosine and L-DOPA as the substrate of monophenolase and diphenolase. Antiglycation activity was studied by measuring the excitation and emission fluorescence from glucose and fructose reaction with Bovine Serum Albumin. Antioxidant activity was measured using the DPPH radical scavenging assay. The result showed that the ethanolic extract of fruit flesh has higher potency as tyrosinase inhibitor (IC50 of 393.8 mg/L and IC50 of 448 mg/L, respectively for monophenolase and diphenolase). Antiglycation assay showed that the ethanolic extract of stem bark provides the strongest antiglycation activity with an IC50 of 118.1 mg/L. Meanwhile, fruit peel provides the strongest antioxidant activity with an IC50 of 5.5 mg/L. Fractionation of ethanolic extracts of each part of X. granatum tree yield fractions with lower bioactivity compared to the crude extract. Moreover, stem extract and fractions from two different locations (Tarakan and Kendari) tend to have different bioactivities strengths.  The stem part of X granatum could be developed as new raw material of cosmetic product in Indonesia, while ethanol as the solvent for extraction, and the different bioactivity of stem extract from different location can be the consideration for the industry to standardize the extract prior to production of final product.


2021 ◽  
Vol 10 (2) ◽  
pp. 233-242
Author(s):  
Muslimin Muslimin ◽  
Susiana Susiana ◽  
Aditya Hikmat Nugraha

Penelitian mengenai Produksi dan Laju Dekomposisi Serasah Mangrove Xylocarpus granatum dan Rhizophora apiculata di Perairan Busung dan Tanjung Unggat Pulau Bintan. Tujuan penelitian ini adalah untuk membandingkan produksi dan laju dekomposisi serasah mangrove Xylocarpus granatum dan Rhizophora apiculata di perairan Busung dan Tanjung Unggat, Pulau Bintan. Penelitian ini di laksanakan pada bulan Februari – Mei 2020 mengenai produksi dan laju dekomposisi serasah mangrove X. granatum dan R. apiculata di perairan Busung dan Tanjung Unggat Pulau Bintan. Penelitian ini bertujuan membandingkan produksi dan laju dekomposisi serasah mangrove X. granatum dan  R. apiculata. Penelitian ini dilakukan dengan penentuan lokasi, kemudian persiapan alat dan bahan dan dilanjutkan dengan pengambilan data kerapatan mangrove dan pengambilan data serasah serta laju dekomposisi. Hasil penelitian ditemukan 2 jenis mangrove di 2 stasiun yaitu X. granatum dan R. apiculata. Kerapatan total di Desa Busung berjumlah 2267 pohon/ha tergolong sangat padat dan masih dalam kondisi baik sedangkan kerapatan total di Tanjung Unggat berjumlah 1200 pohon/ha tergolong sedang dan masih dalam kondisi baik. Produksi serasah tertinggi yaitu terjadi pada Stasiun Busung yaitu R. apiculata 1.47 g/m2/hari dan X. ganatum 0.83 g/m2/hari dengan kerapatan yang padat dan untuk hasil terendah terjadi pada stasiun Tanjung Unggat yaitu R. apiculata 1.09 g/m2/hari dan X. granatum 0.65 g/m2/hari dengan kerapatan sedang. Laju dekomposisi serasah daun spesies X. granatum menunjukkan nilai 0.0192 dan Laju dekomposisi serasah daun spesies R. apiculata menunjukkan nilai 0.0203. Laju dekomposisi sersah daun terjadi penurunan yang sangat signifikan pada hari ke 14 yaitu dengan kisaran 0.04 – 0.06 gr/hr. Sedangkan pada hari ke-14 sampai hari ke-28 relatif  konstan, dengan kisaran 0.01 – 0.03 gr/hr. Research on the Production and Decomposition Rate of Xylocarpus granatum and Rhizophora apiculata Mangrove Litter in Busung and Tanjung Unggat Waters, Bintan Island. The purpose of this study was to compare the production and decomposition rate of mangrove litter from Xylocarpus granatum and Rhizophora apiculata in the waters of Busung and Tanjung Unggat, Bintan Island. This research was conducted in February - May 2020 regarding the production and decomposition rate of mangrove litter X. granatum and R. apiculata in the waters of Busung and Tanjung Unggat Bintan Island. This study aims to compare the production and decomposition rate of mangrove litter X. granatum and R. apiculata. This research was conducted by determining the location, then preparing the tools and materials, followed by collecting data on mangrove density and data collection of litter and decomposition rate. The results found 2 types of mangroves at 2 stations, namely X. granatum and R. apiculata. The total density in Busung Village was 2267 trees / ha which was classified as very dense and still in good condition, while the total density in Tanjung Unggat was 1200 trees / ha which was classified as moderate and still in good condition. The highest litter production occurred at Busung Station, namely R. apiculata 1.47 g/M2/day and X. granatum 0.83 g/m2 /day with a dense density and for the lowest yield occurred at Tanjung Unggat station, namely R. apiculata 1.09 g/m2/day and X. granatum 0.65 g/m2/day with moderate density. The leaf litter decomposition rate of species X. granatum showed a value of 0.0192 and the rate of decomposition of leaf litter of species R. apiculata showed a value of 0.0203. The decomposition rate of leaf litter decreased significantly on day 14, in the range of 0.04 - 0.06 gr/day. Meanwhile, on day 14 to day 28 it is relatively constant, with a range of 0.01 - 0.03 g/day.


2016 ◽  
Vol 633 ◽  
pp. 33-39 ◽  
Author(s):  
Qiang Gao ◽  
Yuan Gao ◽  
Han Song ◽  
Jianli Li ◽  
Yibing Wu ◽  
...  

Phytomedicine ◽  
2010 ◽  
Vol 17 (8-9) ◽  
pp. 569-574 ◽  
Author(s):  
V. Lakshmi ◽  
N. Singh ◽  
S. Shrivastva ◽  
S.K. Mishra ◽  
P. Dharmani ◽  
...  

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