Synthesis of 1‐(3‐(1‐substituted‐1,2,3‐triazol‐4‐yl)‐1,2,4‐triazol‐5‐yl)‐tetrazoles by Sequential Assembly of Azole Fragments

2021 ◽  
Vol 6 (45) ◽  
pp. 12890-12894
Author(s):  
Eugene Zviagin ◽  
Vyacheslav Saraev ◽  
Dmytro Sysoiev ◽  
Blanka Klepetářová ◽  
Maryna Mazur ◽  
...  
Keyword(s):  
Sequential Assembly

scholarly journals CAD integrated automatic recognition of weld paths

2021 ◽  
Author(s):  
Tuan Anh Tran ◽  
Andrei Lobov ◽  
Tord Hansen Kaasa ◽  
Morten Bjelland ◽  
Ole Terje Midling
Keyword(s):  
Life Cycle ◽  
Spatial Analysis ◽  
Product Life Cycle ◽  
Real Life ◽  
Automatic Recognition ◽  
Integrated Method ◽  
Weld Joints ◽  
Related Information ◽  
Almost All ◽  
Sequential Assembly

AbstractIn this paper, a CAD integrated method is proposed for automatic recognition of potential weld locations in large assembly structures predominantly comprised of weld joints. The intention is to reduce the total man-hours spent on manually locating, assigning, and maintaining weld-related information throughout the product life cycle. The method utilizes spatial analysis of extracted stereolithographic data in combination with available CAD functions to determine whether the accessibility surrounding a given intersection edge is sufficient for welding. To demonstrate the method, a system is developed in Siemens NX using their NXOpen Python API. The paper presents the application of the method to real-life use cases in varying complexity in cooperation with industrial partners. The system is able to correctly recognize almost all weld lines for the parts considered within a few minutes. Some exceptions are known for particular intersection lines located deep within notched joints and geometries weldable through sequential assembly, which are left as a subject to further works.

The yeast KRE5 gene encodes a probable endoplasmic reticulum protein required for (1----6)-beta-D-glucan synthesis and normal cell growth

1990 ◽  
Vol 10 (6) ◽  
pp. 3013-3019
Author(s):  
P Meaden ◽  
K Hill ◽  
J Wagner ◽  
D Slipetz ◽  
S S Sommer ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Cell Wall ◽  
Cell Growth ◽  
Normal Cell ◽  
Secretory Pathway ◽  
Endoplasmic Reticulum Retention Signal ◽  
Endoplasmic Reticulum Protein ◽  
Glucan Synthesis ◽  
Retention Signal ◽  
Sequential Assembly

Yeast kre mutants define a pathway of cell wall (1----6)-beta-D-glucan synthesis, and mutants in genes KRE5 and KRE6 appear to interact early in such a pathway. We have cloned KRE5, and the sequence predicts the product to be a large, hydrophilic, secretory glycoprotein which contains the COOH-terminal endoplasmic reticulum retention signal, HDEL. Deletion of the KRE5 gene resulted in cells with aberrant morphology and extremely compromised growth. Suppressors to the KRE5 deletions arose at a frequency of 1 in 10(7) to 1 in 10(8) and permitted an analysis of deletions which were found to contain no alkali-insoluble (1----6)-beta-D-glucan. These results indicate a role for (1----6)-beta-D-glucan in normal cell growth and suggest a model for sequential assembly of (1----6)-beta-D-glucan in the yeast secretory pathway.

scholarly journals Total synthesis of aStreptococcus pneumoniaeserotype 12F CPS repeating unit hexasaccharide

2017 ◽  
Vol 13 ◽  
pp. 164-173 ◽  
Author(s):  
Peter H Seeberger ◽  
Claney L Pereira ◽  
Subramanian Govindan
Keyword(s):  
Total Synthesis ◽  
Capsular Polysaccharide ◽  
Severe Disease ◽  
Building Blocks ◽  
Positive Bacterium ◽  
Linear Approach ◽  
Starting Point ◽  
Branching Points ◽  
Glycoconjugate Vaccines ◽  
Sequential Assembly

The Gram-positive bacteriumStreptococcus pneumoniaecauses severe disease globally. Vaccines that preventS. pneumoniaeinfections induce antibodies against epitopes within the bacterial capsular polysaccharide (CPS). A better immunological understanding of the epitopes that protect from bacterial infection requires defined oligosaccharides obtained by total synthesis. The key to the synthesis of theS. pneumoniaeserotype 12F CPS hexasaccharide repeating unit that is not contained in currently used glycoconjugate vaccines is the assembly of the trisaccharide β-D-GalpNAc-(1→4)-[α-D-Glcp-(1→3)]-β-D-ManpNAcA, in which the branching points are equipped with orthogonal protecting groups. A linear approach relying on the sequential assembly of monosaccharide building blocks proved superior to a convergent [3 + 3] strategy that was not successful due to steric constraints. The synthetic hexasaccharide is the starting point for further immunological investigations.

scholarly journals Sequential Assembly of the Nucleotide Excision Repair Factors In Vivo

2001 ◽  
Vol 8 (1) ◽  
pp. 213-224 ◽  
Author(s):  
Marcel Volker ◽  
Martijn J Moné ◽  
Parimal Karmakar ◽  
Anneke van Hoffen ◽  
Wouter Schul ◽  
...  
Keyword(s):  
Nucleotide Excision Repair ◽  
Excision Repair ◽  
Nucleotide Excision ◽  
Sequential Assembly

Construction of One- and Two-Dimensional Nanostructures by the Sequential Assembly of Quadruplex DNA Scaffolds

2019 ◽  
Vol 20 (6) ◽  
pp. 2207-2217 ◽  
Author(s):  
Yanwei Cao ◽  
Ye Kuang ◽  
Luyan Yang ◽  
Pi Ding ◽  
Renjun Pei
Keyword(s):  
Two Dimensional ◽  
Quadruplex Dna ◽  
Dna Scaffolds ◽  
Sequential Assembly

Thin Films of Prussian Blue: Sequential Assembly, Patterning and Electron Transport Properties at the Nanometric Scale

2010 ◽  
Vol 10 (8) ◽  
pp. 5042-5050 ◽  
Author(s):  
Saioa Cobo ◽  
Gábor Molnár ◽  
Franck Carcenac ◽  
Petra Á Szilágyi ◽  
Lionel Salmon ◽  
...  
Keyword(s):  
Thin Films ◽  
Electron Transport ◽  
Transport Properties ◽  
Prussian Blue ◽  
Electron Transport Properties ◽  
Sequential Assembly

Sequential assembly of 3D perfusable microfluidic hydrogels

2014 ◽  
Vol 25 (11) ◽  
pp. 2491-2500 ◽  
Author(s):  
Jiankang He ◽  
Lin Zhu ◽  
Yaxiong Liu ◽  
Dichen Li ◽  
Zhongmin Jin
Keyword(s):  
Sequential Assembly

scholarly journals Sequential assembly of collagen revealed by atomic force microscopy

1995 ◽  
Vol 68 (5) ◽  
pp. 2124-2128 ◽  
Author(s):  
M. Gale ◽  
M.S. Pollanen ◽  
P. Markiewicz ◽  
M.C. Goh
Keyword(s):  
Atomic Force Microscopy ◽  
Force Microscopy ◽  
Atomic Force ◽  
Sequential Assembly
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