Discovery of Easily Synthesizable 4, 4‐Dimethylimidazolidin‐2‐ones as Potent Androgen Receptor Antagonists for Prostate Cancer

2021 ◽  
Vol 6 (33) ◽  
pp. 8741-8745
Author(s):  
Muralikrishna Yaragani ◽  
Prasad Yadlapalli ◽  
Sriram Raghavan ◽  
Giridhar Thota ◽  
Venkata Basaveswara Rao Mandava ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Receptor Antagonists ◽  
Androgen Receptor Antagonists

Current androgen receptor antagonists under investigation for resistant prostate cancer

2021 ◽  
Author(s):  
Maria Concetta Nigro ◽  
Veronica Mollica ◽  
Andrea Marchetti ◽  
Michael Cheng ◽  
Matteo Rosellini ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Receptor Antagonists ◽  
Androgen Receptor Antagonists

scholarly journals Inhibition of prostate cancer cell growth by second-site androgen receptor antagonists

2009 ◽  
Vol 106 (29) ◽  
pp. 12178-12183 ◽  
Author(s):  
J. D. Joseph ◽  
B. M. Wittmann ◽  
M. A. Dwyer ◽  
H. Cui ◽  
D. A. Dye ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cell Growth ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Receptor Antagonists ◽  
Cancer Cell Growth ◽  
Androgen Receptor Antagonists

scholarly journals In Silico Discovery of Androgen Receptor Antagonists with Activity in Castration Resistant Prostate Cancer

2012 ◽  
Vol 26 (11) ◽  
pp. 1836-1846 ◽  
Author(s):  
Howard C. Shen ◽  
Kumaran Shanmugasundaram ◽  
Nicholas I. Simon ◽  
Changmeng Cai ◽  
Hongyun Wang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
In Silico ◽  
Castration Resistant Prostate Cancer ◽  
Receptor Antagonists ◽  
Castration Resistant ◽  
Androgen Receptor Antagonists

Recent Androgen Receptor Antagonists in Prostate Cancer

2014 ◽  
Vol 14 (8) ◽  
pp. 655-663 ◽  
Author(s):  
Xufang Lu ◽  
Kang Dun ◽  
Yang Wang ◽  
Yong Yang ◽  
Qidong You ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Receptor Antagonists ◽  
Androgen Receptor Antagonists

Chapter 6. Novel Androgen Receptor Antagonists for the Treatment of Prostate Cancer

2010 ◽  
pp. 120-141
Author(s):  
Ashvinikumar V. Gavai ◽  
William R. Foster ◽  
Aaron Balog ◽  
Gregory D. Vite
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Receptor Antagonists ◽  
Androgen Receptor Antagonists

Papers of note in Science Translational Medicine

2016 ◽  
Vol 9 (423) ◽  
pp. ec88-ec88
Author(s):  
Leslie K. Ferrarelli
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
T Cell ◽  
Cell Response ◽  
T Cell Response ◽  
Receptor Antagonists ◽  
Tumor Relapse ◽  
Link Type ◽  
Early Tumor ◽  
Androgen Receptor Antagonists

CANCERA winning combinationAndrogen receptor antagonists compromise the T cell response against prostate cancer, leading to early tumor relapse.Y. Pu, M. Xu, Y. Liang, K. Yang, Y. Guo, X. Yang, Y.-X. Fu, Androgen receptor antagonists compromise T cell response against prostate cancer leading to early tumor relapse. Sci. Transl. Med.8, 333ra47 (2016). [Abstract]NEUROTOXICITYInsights into neuronal cell deathA method to culture human cortical neurons that yielded a balanced network of excitatory and inhibitory neurons revealed that these cells die in a PARP-dependent manner after neurotoxic insult.J.-C. Xu, J. Fan, X. Wang, S. M. Eacker, T.-I. Kam, L. Chen, X. Yin, J. Zhu, Z. Chi, H. Jiang, R. Chen, T. M. Dawson, V. L. Dawson, Cultured networks of excitatory projection neurons and inhibitory interneurons for studying human cortical neurotoxicity. Sci. Transl. Med.8, 333ra48 (2016). [Abstract]ATHEROSCLEROSISDissolving away cholesterolThe cyclic oligosaccharide 2-hydroxypropyl-β-cyclodextrin facilitates atheroprotective mechanisms through oxysterol-mediated reprogramming of macrophages.S. Zimmer, A. Grebe, S. S. Bakke, N. Bode, B. Halvorsen, T. Ulas, M. Skjelland, D. De Nardo, L. I. Labzin, A. Kerksiek, C. Hempel, M. T. Heneka, V. Hawxhurst, M. L. Fitzgerald, J. Trebicka, I. Björkhem, J.-Å. Gustafsson, M. Westerterp, A. R. Tall, S. D. Wright, T. Espevik, J. L. Schultze, G. Nickenig, D. Lütjohann, E. Latz, Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming. Sci. Transl. Med. 8, 333ra50 (2016). [Abstract]

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