Design and Synthesis of New Tubulin Polymerization Inhibitors Inspired from Combretastatin A‐4: An Anticancer Agent

2020 ◽  
Vol 5 (37) ◽  
pp. 11560-11572
Author(s):  
Akanksha Sharma ◽  
Doddabasappa Talimarada ◽  
Umesh Prasad Yadav ◽  
Nidhi Singh ◽  
A. Sudharshan Reddy ◽  
...  
Keyword(s):  
Anticancer Agent ◽  
Tubulin Polymerization ◽  
Design And Synthesis ◽  
Tubulin Polymerization Inhibitors

Design and synthesis of 1,2,3-triazolo linked benzo[ d ]imidazo[2,1- b ]thiazole conjugates as tubulin polymerization inhibitors

2017 ◽  
Vol 25 (13) ◽  
pp. 3285-3297 ◽  
Author(s):  
Siddiq Pasha Shaik ◽  
M.V.P.S. Vishnuvardhan ◽  
Faria Sultana ◽  
A.V. Subba Rao ◽  
Chandrakant Bagul ◽  
...  
Keyword(s):  
Tubulin Polymerization ◽  
Design And Synthesis ◽  
Tubulin Polymerization Inhibitors

Design and Synthesis of Aminostilbene-Arylpropenones as Tubulin Polymerization Inhibitors

ChemMedChem ◽  
2014 ◽  
Vol 9 (11) ◽  
pp. 2565-2579 ◽  
Author(s):  
Ahmed Kamal ◽  
G. Bharath Kumar ◽  
Sowjanya Polepalli ◽  
Anver Basha Shaik ◽  
Vangala Santhosh Reddy ◽  
...  
Keyword(s):  
Tubulin Polymerization ◽  
Design And Synthesis ◽  
Tubulin Polymerization Inhibitors

Design and synthesis of substituted dihydropyrimidinone derivatives as cytotoxic and tubulin polymerization inhibitors

2019 ◽  
Vol 93 ◽  
pp. 103317 ◽  
Author(s):  
Sravani Sana ◽  
Ramya Tokala ◽  
Deepti Madanlal Bajaj ◽  
Narayana Nagesh ◽  
Kiran Kumar Bokara ◽  
...  
Keyword(s):  
Tubulin Polymerization ◽  
Design And Synthesis ◽  
Tubulin Polymerization Inhibitors

Design and synthesis of pyrazole/isoxazole linked arylcinnamides as tubulin polymerization inhibitors and potential antiproliferative agents

2015 ◽  
Vol 13 (40) ◽  
pp. 10162-10178 ◽  
Author(s):  
Ahmed Kamal ◽  
Anver Basha Shaik ◽  
Bala Bhaskara Rao ◽  
Irfan Khan ◽  
G. Bharath Kumar ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Tubulin Polymerization ◽  
Human Cancer Cell ◽  
Antiproliferative Agents ◽  
Human Cancer Cell Lines ◽  
Design And Synthesis ◽  
Tubulin Polymerization Inhibitors

A series of pyrazole/isoxazole linked arylcinnamide conjugates were synthesized and investigated for their cytotoxic activity against a panel of four human cancer cell lines. Most of them have shown significant cytotoxicity apart from potential tubulin depolymerization activity.

scholarly journals Simple Thalidomide Analogs in Melanoma: Synthesis and Biological Activity

2021 ◽  
Vol 11 (13) ◽  
pp. 5823
Author(s):  
Alexia Barbarossa ◽  
Alessia Catalano ◽  
Jessica Ceramella ◽  
Alessia Carocci ◽  
Domenico Iacopetta ◽  
...  
Keyword(s):  
Anticancer Agent ◽  
Ring System ◽  
In Vitro Assays ◽  
Tubulin Polymerization ◽  
Cytotoxic Effects ◽  
Ongoing Research ◽  
Drug Candidates ◽  
Small Series ◽  
Clinical Interest

Thalidomide is an old well-known drug that is still of clinical interest, despite its teratogenic activities, due to its antiangiogenic and immunomodulatory properties. Therefore, efforts to design safer and effective thalidomide analogs are continually ongoing. Research studies on thalidomide analogs have revealed that the phthalimide ring system is an essential pharmacophoric fragment; thus, many phthalimidic compounds have been synthesized and evaluated as anticancer drug candidates. In this study, a panel of selected in vitro assays, performed on a small series of phthalimide derivatives, allowed us to characterize compound 2k as a good anticancer agent, acting on A2058 melanoma cell line, which causes cell death by apoptosis due to its capability to inhibit tubulin polymerization. The obtained data were confirmed by in silico assays. No cytotoxic effects on normal cells have been detected for this compound that proves to be a valid candidate for further investigations to achieve new insights on possible mechanism of action of this class of compounds as anticancer drugs.

Semi-synthesis and anti-lung cancer activity evaluation of aryl dihydrothiazol acyl podophyllotoxin ester derivatives

RSC Advances ◽  
2015 ◽  
Vol 5 (35) ◽  
pp. 27775-27784 ◽  
Author(s):  
Hong-Yan Lin ◽  
Li-Fei Bai ◽  
Fang Wang ◽  
Xun Wu ◽  
Lu-Jing Han ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Anticancer Agent ◽  
Tubulin Polymerization ◽  
Inhibition Effect ◽  
Activity Evaluation ◽  
Podophyllotoxin Derivatives ◽  
Cancer Activity

S12, the best anticancer agent among the 17 podophyllotoxin derivatives, showed a proliferative inhibition effect via inhibiting tubulin polymerization.

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