Graphene Oxide as a Metal‐free Carbocatalyst for Direct Amide Synthesis from Carboxylic Acid and Amine Under Solvent‐Free Reaction Condition

2020 ◽  
Vol 5 (27) ◽  
pp. 8295-8300 ◽  
Author(s):  
Khushbu P. Patel ◽  
Eknath M. Gayakwad ◽  
Ganapati S. Shankarling
Keyword(s):  
Graphene Oxide ◽  
Carboxylic Acid ◽  
Solvent Free ◽  
Metal Free ◽  
Reaction Condition ◽  
Amide Synthesis ◽  
Solvent Free Reaction

Graphene Oxide: A Metal‐Free Carbocatalyst for the Synthesis of Diverse Amides under Solvent‐Free Conditions

2019 ◽  
Vol 361 (9) ◽  
pp. 2107-2116 ◽  
Author(s):  
Khushbu P. Patel ◽  
Eknath M. Gayakwad ◽  
Vilas V. Patil ◽  
Ganapati S. Shankarling
Keyword(s):  
Graphene Oxide ◽  
Solvent Free ◽  
Metal Free ◽  
Solvent Free Conditions

scholarly journals Nanorod-Shaped Basic Al2O3 Catalyzed N,N-Diformylation of Bisuracil Derivatives: A Greener “NOSE” Approach

2013 ◽  
Vol 2013 ◽  
pp. 1-6
Author(s):  
Vijay K. Das ◽  
Ashim J. Thakur
Keyword(s):  
Organic Synthesis ◽  
Recyclable Catalyst ◽  
Solvent Free ◽  
Reaction Condition ◽  
Solvent Free Reaction

A feasible “NOSE” (nanoparticles-catalyzed organic synthesis enhancement) protocol has been developed for N,N-diformylation of bisuracil derivatives using nano-Al2O3 rods as an efficient, inexpensive, and recyclable catalyst under solvent-free reaction condition at 40°C. The catalyst was reused up to the 4th cycle without affecting the rate and yield of the N,N-diformylation products appreciably.

scholarly journals Solvent- and transition metal-free amide synthesis from phenyl esters and aryl amines

RSC Advances ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 1536-1540 ◽  
Author(s):  
Sergey A. Rzhevskiy ◽  
Alexandra A. Ageshina ◽  
Gleb A. Chesnokov ◽  
Pavel S. Gribanov ◽  
Maxim A. Topchiy ◽  
...  
Keyword(s):  
Transition Metal ◽  
Environmentally Friendly ◽  
Solvent Free ◽  
Metal Free ◽  
Amide Synthesis ◽  
Aryl Amines ◽  
Environmentally Friendly Approach

A new environmentally friendly approach to transition metal- and solvent-free amide synthesis from aryl esters and aryl amines is described.

scholarly journals N-Iodosuccinimide as a Precatalyst for Direct Cross-Coupling of Alcohols with C-Nucleophiles under Solvent-Free Reaction Conditions

Catalysts ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 850
Author(s):  
Njomza Ajvazi ◽  
Stojan Stavber
Keyword(s):  
Large Scale ◽  
Bond Formation ◽  
Cross Coupling ◽  
Solvent Free ◽  
Reaction Conditions ◽  
Benzyl Alcohols ◽  
Metal Free ◽  
Direct Cross ◽  
Synthetic Routes ◽  
Solvent Free Reaction

C–C bond formation is one of the most important implements in synthetic organic chemistry. In pursuit of effective synthetic routes functioning under greener pathways to achieve direct C–C bond formation, we report N-iodosuccinimide (NIS) as the most effective precatalyst among the N-halosuccinimides (NXSs) for the direct cross-coupling of benzyl alcohols with C-nucleophiles under solvent-free reaction conditions (SFRC). The protocol is metal-free, and air- and water-tolerant, providing a large-scale synthesis with almost quantitative yields.

Hypervalent Iodine Mediated Efficient Solvent-Free Regioselective Halogenation and Thiocyanation of Fused N-Heterocycles

Synlett ◽  
2019 ◽  
Vol 30 (13) ◽  
pp. 1573-1579 ◽  
Author(s):  
Divakar Reddy Indukuri ◽  
Gal Reddy Potuganti ◽  
Manjula Alla
Keyword(s):  
Alkali Metal ◽  
Solvent Free ◽  
Heterocyclic Amines ◽  
Ammonium Salts ◽  
Hypervalent Iodine ◽  
Pyrimidine Derivatives ◽  
Reaction Conditions ◽  
Metal Free ◽  
Solvent Free Reaction

A facile, rapid, metal-free regioselective halogenation and thiocyanation of imidazo[1,2-a]pyridine/pyrimidine heterocycles has been achieved under solvent-free reaction conditions. Halogenations and thiocyanation of the heterocycles could be accomplished by simple grinding of reactants and hypervalent iodine reagents with the corresponding alkali metal or ammonium salts. The method has been extrapolated to a cleaner synthesis of brominated imidazo[1,2-a]pyridine/pyrimidine derivatives, starting from the corresponding heterocyclic amines and substituted α-bromoketones, utilising HBr generated in situ as the source of bromine.

Organic nanocages: a promising testbed for catalytic CO2 conversion

2019 ◽  
Vol 3 (10) ◽  
pp. 2567-2571 ◽  
Author(s):  
MD. Waseem Hussain ◽  
Arkaprabha Giri ◽  
Abhijit Patra
Keyword(s):  
Solvent Free ◽  
Co2 Conversion ◽  
Reaction Conditions ◽  
Metal Free ◽  
Organic Carbonates ◽  
Solvent Free Reaction

Shape-persistent N-rich organic cages are demonstrated as catalysts for the metal-free conversion of CO2 and epoxides into cyclic organic carbonates under solvent-free reaction conditions.

Chlorosulfonic Acid Supported Piperidine-4-carboxylic Acid (PPCA) Functionalized Fe3O4 Nanoparticles (Fe3O4-PPCA): The Efficient, Green and Reusable Nanocatalyst for the Synthesis of Pyrazolyl Coumarin Derivatives under Solvent-Free Conditions

2019 ◽  
Vol 22 (2) ◽  
pp. 123-128
Author(s):  
Setareh Habibzadeh ◽  
Hassan Ghasemnejad-Bosra ◽  
Mina Haghdadi ◽  
Soheila Heydari-Parastar
Keyword(s):  
Carboxylic Acid ◽  
Fe3o4 Nanoparticles ◽  
High Efficiency ◽  
Reaction Times ◽  
Chlorosulfonic Acid ◽  
Aromatic Aldehydes ◽  
Solvent Free ◽  
Magnetic Nanocatalyst ◽  
One Pot ◽  
Solvent Free Conditions

Background: In this study, we developed a convenient methodology for the synthesis of coumarin linked to pyrazolines and pyrano [2,3-h] coumarins linked to 3-(1,5-diphenyl-4,5- dihydro-1H-pyrazol-3-yl)-chromen-2-one derivatives using Chlorosulfonic acid supported Piperidine-4-carboxylic acid (PPCA) functionalized Fe3O4 nanoparticles (Fe3O4-PPCA) catalyst. Materials and Methods:: Fe3O4-PPCA was investigated as an efficient and magnetically recoverable Nanocatalyst for the one-pot synthesis of substituted coumarins from the reaction of coumarin with a variety of aromatic aldehydes in high to excellent yield at room temperature under solvent-free conditions. The magnetic nanocatalyst can be easily recovered by applying an external magnet device and reused for at least 10 reaction runs without considerable loss of reactivity. Results and Conclusion: The advantages of this protocol are the use of commercially available materials, simple and an inexpensive procedure, easy separation, and an eco-friendly procedure, and it shows good reaction times, good to high yields, inexpensive and practicability procedure, and high efficiency.

scholarly journals 3′-Methyl-2-oxo-1′,5′-diphenyl-1′,7′-dihydrospiro[indoline-3,4′-pyrazolo[3,4-b]pyridine]-6′-carboxylic Acid

Molbank ◽  
10.3390/m1214 ◽  
2021 ◽  
Vol 2021 (2) ◽  
pp. M1214
Author(s):  
Pablo E. Romo ◽  
Braulio Insuasty ◽  
Jairo Quiroga ◽  
Rodrigo Abonia
Keyword(s):  
Carboxylic Acid ◽  
Microwave Irradiation ◽  
Reaction Condition ◽  
Water As Solvent

3′-methyl-2-oxo-1′,5′-diphenyl-1′,7′-dihydrospiro[indoline-3,4′-pyrazolo[3,4-b]pyridine]-6′-carboxylic acid was synthesized using diverse conditions. The best reaction condition consisted of using water as solvent under microwave irradiation, affording product in 76% yield.

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