In Vitro and In Silico Studies on the Toxic Effects of Antibacterial Drugs as Human Serum Paraoxonase 1 Inhibitor

2019 ◽  
Vol 4 (33) ◽  
pp. 9731-9736 ◽  
Author(s):  
Cüneyt Türkeş ◽  
Şükrü Beydemir ◽  
Ömer İrfan Küfrevioğlu
Keyword(s):  
Human Serum ◽  
In Silico ◽  
Toxic Effects ◽  
Paraoxonase 1 ◽  
Antibacterial Drugs ◽  
In Silico Studies ◽  
Serum Paraoxonase

In Vitro Inhibition Effect of Some Dihydroxy Coumarin Compounds on Purified Human Serum Paraoxonase 1 (PON1)

2012 ◽  
Vol 168 (6) ◽  
pp. 1540-1548 ◽  
Author(s):  
Mahmut Erzengin ◽  
Ismet Basaran ◽  
Umit Cakir ◽  
Aynur Aybey ◽  
Selma Sinan
Keyword(s):  
Human Serum ◽  
Paraoxonase 1 ◽  
Inhibition Effect ◽  
In Vitro Inhibition ◽  
Coumarin Compounds ◽  
Serum Paraoxonase

scholarly journals Unraveling the Antioxidant, Binding and Health-Protecting Properties of Phenolic Compounds of Beers with Main Human Serum Proteins: In Vitro and In Silico Approaches

Molecules ◽  
2020 ◽  
Vol 25 (21) ◽  
pp. 4962
Author(s):  
Raja Mohamed Beema Shafreen ◽  
Selvaraj Alagu Lakshmi ◽  
Shunmugiah Karutha Pandian ◽  
Yong Seo Park ◽  
Young Mo Kim ◽  
...  
Keyword(s):  
Human Serum ◽  
In Silico ◽  
Serum Proteins ◽  
In Silico Analysis ◽  
Cardiovascular Effects ◽  
In Vivo Studies ◽  
In Silico Studies ◽  
Human Serum Proteins

Our recently published in vivo studies and growing evidence suggest that moderate consumption of beer possesses several health benefits, including antioxidant and cardiovascular effects. Although beer contains phenolic acids and flavonoids as the major composition, and upon consumption, the levels of major components increase in the blood, there is no report on how these beer components interact with main human serum proteins. Thus, to address the interaction potential between beer components and human serum proteins, the present study primarily aims to investigate the components of beer from different industrial sources as well as their mode of interaction through in silico analysis. The contents of the bioactive compounds, antioxidant capacities and their influence on binding properties of the main serum proteins in human metabolism (human serum albumin (HSA), plasma circulation fibrinogen (PCF), C-reactive protein (CRP) and glutathione peroxidase 3 (GPX3)) were studied. In vitro and in silico studies indicated that phenolic substances presented in beer interact with the key regions of the proteins to enhance their antioxidant and health properties. We hypothesize that moderate consumption of beer could be beneficial for patients suffering from coronary artery disease (CAD) and other health advantages by regulating the serum proteins.

scholarly journals In vitro inhibition effect of some coumarin compounds on purified human serum paraoxonase 1 (PON1)

2015 ◽  
Vol 31 (4) ◽  
pp. 534-537 ◽  
Author(s):  
Basak Gokce ◽  
Nahit Gencer ◽  
Oktay Arslan ◽  
Mert Olgun Karatas ◽  
Bulent Alici
Keyword(s):  
Human Serum ◽  
Paraoxonase 1 ◽  
Inhibition Effect ◽  
In Vitro Inhibition ◽  
Coumarin Compounds ◽  
Serum Paraoxonase
Sign in / Sign up

Export Citation Format

Share Document