Simple and Label-Free Liquid Crystal-based Optical Sensor for Highly Sensitive and Selective Endotoxin Detection by Aptamer Binding and Separation

2019 ◽  
Vol 4 (4) ◽  
pp. 1416-1422 ◽  
Author(s):  
Zongfu An ◽  
Chang-Hyun Jang
Keyword(s):  
Liquid Crystal ◽  
Optical Sensor ◽  
Label Free ◽  
Highly Sensitive

scholarly journals Highly sensitive and selective liquid crystal optical sensor for detection of ammonia

2017 ◽  
Vol 25 (12) ◽  
pp. 13549 ◽  
Author(s):  
Xiaofang Niu ◽  
Yuanbo Zhong ◽  
Rui Chen ◽  
Fei Wang ◽  
Dan Luo
Keyword(s):  
Liquid Crystal ◽  
Optical Sensor ◽  
Highly Sensitive

scholarly journals Color-Indicating, Label-Free, Dye-Doped Liquid Crystal Organic-Polymer-Based-Bioinspired Sensor for Biomolecule Immunodetection

Polymers ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 2294
Author(s):  
Haw-Ming Huang ◽  
Er-Yuan Chuang ◽  
Fu-Lun Chen ◽  
Jia-De Lin ◽  
Yu-Cheng Hsiao
Keyword(s):  
Liquid Crystal ◽  
Smart Phone ◽  
Organic Polymer ◽  
The Novel ◽  
Label Free ◽  
Home Test ◽  
Sensing Technology ◽  
Highly Sensitive ◽  
Vertically Aligned ◽  
Alignment Layers

The highly sensitive interfacial effects between liquid crystal (LC) and alignment layers make LC-bioinspired sensors an important technology. However, LC-bioinspired sensors are limited by quantification requiring a polarized microscope and expensive equipment, which makes it difficult to commercialize LC-bioinspired sensors. In this report, we first demonstrate that dye-doped LC (DDLC) chips coated with vertically aligned layers can be employed as a new LC-bioinspired sensing technology. The DDLC-bioinspired sensor was tested by detecting bovine serum albumin (BSA) and immunocomplexes of BSA pairs. The intensities of the dye color of the DDLC-bioinspired sensor can be changed with the concentrations of biomolecules and immunocomplexes. A detection limit of 0.5 µg/mL was shown for the color-indicating DDLC-bioinspired sensors. We also designed a new method to use the quantitative DDLC-bioinspired sensor with a smart-phone for potential of home test. The novel DDLC-bioinspired sensor is cheap, label-free, and easy to use, furthering the technology for home and field-based disease-related detection.

scholarly journals Highly sensitive and selective optical sensor for lead ion detection based on liquid crystal decorated with DNAzyme

2019 ◽  
Vol 27 (21) ◽  
pp. 30421 ◽  
Author(s):  
Xiaofang Niu ◽  
Yanjun Liu ◽  
Fei Wang ◽  
Dan Luo
Keyword(s):  
Liquid Crystal ◽  
Optical Sensor ◽  
Lead Ion ◽  
Ion Detection ◽  
Highly Sensitive

scholarly journals Optical Monitoring of the Production Quality of Si-Nanoribbon Chips Intended for the Detection of ASD-Associated Oligonucleotides

Micromachines ◽  
2021 ◽  
Vol 12 (2) ◽  
pp. 147
Author(s):  
Kristina A. Malsagova ◽  
Tatyana O. Pleshakova ◽  
Vladimir P. Popov ◽  
Igor N. Kupriyanov ◽  
Rafael A. Galiullin ◽  
...  
Keyword(s):  
Production Quality ◽  
Autism Spectrum ◽  
Covalent Immobilization ◽  
Biological Macromolecules ◽  
Label Free ◽  
Raman Scattering Spectroscopy ◽  
Dna Oligonucleotides ◽  
Highly Sensitive ◽  
Highly Sensitive Detection

Gas-phase etching and optical lithography were employed for the fabrication of a silicon nanoribbon chip (Si-NR chip). The quality of the so-fabricated silicon nanoribbons (Si-NRs) was monitored by optical Raman scattering spectroscopy. It was demonstrated that the structures of the Si-NRs were virtually defect-free, meaning they could be used for highly sensitive detection of biological macromolecules. The Si-NR chips were then used for the highly sensitive nanoelectronics detection of DNA oligonucleotides (oDNAs), which represent synthetic analogs of 106a-5p microRNA (miR-106a-5p), associated with the development of autism spectrum disorders in children. The specificity of the analysis was attained by the sensitization of the Si-NR chip sur-face by covalent immobilization of oDNA probes, whose nucleotide sequence was complementary to the known sequence of miR-106a-5p. The use of the Si-NR chip was demonstrated to al-low for the rapid label-free real-time detection of oDNA at ultra-low (~10−17 M) concentrations.

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