Facile Non-Transition Metal-Catalyzed Synthesis of 2-Thioxo-2,3-dihydroquinazolin-4(1H )-one Derivatives via One-Pot Multicomponent Reactions

2019 ◽  
Vol 4 (1) ◽  
pp. 100-104 ◽  
Author(s):  
Saeed Bahadorikhalili ◽  
Golnaz Rahimzadeh ◽  
Ebrahim Kianmehr ◽  
Samira Ansari ◽  
Haleh Hamedifar ◽  
...  
Keyword(s):  
Transition Metal ◽  
Multicomponent Reactions ◽  
One Pot ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

Transition-Metal-Catalyzed Reactions Involving Arynes

Synthesis ◽  
2017 ◽  
Vol 50 (01) ◽  
pp. 1-16 ◽  
Author(s):  
Santosh Mhaske ◽  
Ranjeet Dhokale
Keyword(s):  
Natural Products ◽  
Transition Metal ◽  
Total Synthesis ◽  
Scientific Community ◽  
Multicomponent Reactions ◽  
Polycyclic Aromatic Compounds ◽  
Polycyclic Aromatic ◽  
Transition Metal Catalyzed ◽  
Catalyzed Reactions ◽  
Metal Catalyzed

The plethora of transformations attainable by the transition-metal-catalyzed reactions of arynes has found immense contemporary interest in the scientific community. This review highlights the scope and importance of transition-metal-catalyzed aryne reactions in the field of synthetic organic chemistry reported to date. It covers transformations achieved by the combination of arynes and various transition metals, which provide a facile access to a biaryl motif, fused polycyclic aromatic compounds, different novel carbocycles, various heterocycles, and complex natural products.1 Introduction2 Insertion of Arynes3 Annulation of Arynes4 Cycloaddition of Arynes5 Multicomponent Reactions of Arynes6 Miscellaneous Reactions of Arynes7 Total Synthesis of Natural Products Using Arynes8 Conclusion

Real-time monitoring of a cobalt-mediated one-pot transition metal-catalyzed multicomponent reaction

2020 ◽  
Vol 508 ◽  
pp. 119654
Author(s):  
Antônio E.M. Crotti ◽  
Daniel Previdi ◽  
Paulo M. Donate ◽  
J. Scott McIndoe
Keyword(s):  
Transition Metal ◽  
Real Time ◽  
Multicomponent Reaction ◽  
Real Time Monitoring ◽  
One Pot ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

scholarly journals Real-Time Monitoring of a Cobalt-Mediated One-Pot Transition Metal Catalyzed Multicomponent Reaction

2020 ◽  
Author(s):  
Antonio Crotti ◽  
Daniel Previdi ◽  
Paulo Donate ◽  
J Scott McIndoe
Keyword(s):  
Transition Metal ◽  
Real Time ◽  
Multicomponent Reaction ◽  
Side Reaction ◽  
Ionization Mass ◽  
One Pot ◽  
Esi Ms ◽  
Transition Metal Catalyzed ◽  
Time Changes ◽  
Metal Catalyzed

In this paper, pressurized sample infusion electrospray ionization mass spectrometry (PSI-ESI-MS) and FTIR spectroscopy was used to investigate the mechanism of a like-Barbier cobalt-mediated one-pot transition metal-catalyzed multicomponent reaction (MCR). The use of charge-tagged aryl halides allowed for the detection of cobalt(II)-promoted hydrodehalogenation products. Although these products were also detected in the off-line ESI-MS monitoring, the ability of PSI-ESI-MS to track real-time changes in the reaction mixture composition proved cobalt(II) was responsible for the undesired transformation. The occurrence of cobalt(II)-promoted hydrodehalogenation as a side reaction in this MCR had not been considered in previous mechanistic proposals and represents an important mechanistic consideration.

Recent Advancements in Transition‐Metal‐Catalyzed One‐Pot Twofold Unsymmetrical Difunctionalization of Arenes

2019 ◽  
Vol 14 (23) ◽  
pp. 4074-4086 ◽  
Author(s):  
Anup Mandal ◽  
Suman Dana ◽  
Deepan Chowdhury ◽  
Mahiuddin Baidya
Keyword(s):  
Transition Metal ◽  
One Pot ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

scholarly journals A combination of experimental and computational methods to study the reactions during a Lignin-First approach

2020 ◽  
Vol 92 (4) ◽  
pp. 631-639
Author(s):  
Ivan Kumaniaev ◽  
Elena Subbotina ◽  
Maxim V. Galkin ◽  
Pemikar Srifa ◽  
Susanna Monti ◽  
...  
Keyword(s):  
Transition Metal ◽  
Hydrogen Transfer ◽  
Transfer Hydrogenation ◽  
Metal Catalyst ◽  
Main Role ◽  
One Pot ◽  
Transition Metal Catalyst ◽  
Transition Metal Catalyzed ◽  
Catalyzed Reactions ◽  
Metal Catalyzed

AbstractCurrent pulping technologies only valorize the cellulosic fiber giving total yields from biomass below 50 %. Catalytic fractionation enables valorization of both cellulose, lignin, and, optionally, also the hemicellulose. The process consists of two operations occurring in one pot: (1) solvolysis to separate lignin and hemicellulose from cellulose, and (2) transition metal catalyzed reactions to depolymerize lignin and to stabilized monophenolic products. In this article, new insights into the roles of the solvolysis step as well as the operation of the transition metal catalyst are given. By separating the solvolysis and transition metal catalyzed hydrogen transfer reactions in space and time by applying a flow-through set-up, we have been able to study the solvolysis and transition metal catalyzed reactions separately. Interestingly, the solvolysis generates a high amount of monophenolic compounds by pealing off the end groups from the lignin polymer and the main role of the transition metal catalyst is to stabilize these monomers by transfer hydrogenation/hydrogenolysis reactions. The experimental data from the transition metal catalyzed transfer hydrogenation/hydrogenolysis reactions was supported by molecular dynamics simulations using ReaXFF.

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