Asymmetric Hydrogenation vs Transfer Hydrogenation in the Reduction of Cyclic Imines

2018 ◽  
Vol 3 (31) ◽  
pp. 8797-8800 ◽  
Author(s):  
Giorgio Facchetti ◽  
Raffaella Bucci ◽  
Marco Fusè ◽  
Isabella Rimoldi
Keyword(s):  
Asymmetric Hydrogenation ◽  
Transfer Hydrogenation

Enantioselective Catalytic Methods for the Elaboration of Chiral Tetrahydro-β-carbolines and Related Scaffolds

Synthesis ◽  
2017 ◽  
Vol 49 (12) ◽  
pp. 2605-2620 ◽  
Author(s):  
Nicolas Glinsky-Olivier ◽  
Xavier Guinchard
Keyword(s):  
Kinetic Resolution ◽  
Asymmetric Reduction ◽  
Asymmetric Hydrogenation ◽  
Transfer Hydrogenation ◽  
Chiral Molecules ◽  
Chiral Phosphoric Acid ◽  
Hydrogenation Reactions ◽  
Synthetic Intermediates ◽  
Catalyzed Reactions

Tetrahydro-β-carbolines are important synthetic intermediates in the total synthesis of natural products and of compounds exhibiting strong bioactivities. Over the last decades, catalytic methods using chiral catalysts have been described for their synthesis. This review covers catalytic and enantioselective methods to access chiral tetrahydro-β-carbolines and their applications in the elaboration of complex chiral molecules.1 Introduction2 Asymmetric Reduction of Dihydro-β-carbolines2.1 Asymmetric Transfer Hydrogenation Reactions2.2 Asymmetric Hydrogenation Reactions2.3 Biocatalyzed Reduction of Dihydro-β-carbolines3 Organocatalyzed Pictet–Spengler Reactions3.1 Chiral Thiourea-Catalyzed Reactions3.2 Chiral Phosphoric Acid Catalyzed Reactions4 Pictet–Spengler Reactions of In Situ Generated Cyclic Iminiums5 Organocatalyzed Functionalization of Dihydro-β-carboliniums6 Organocatalyzed Alkylation of Tetrahydro-β-carbolines7 Biocatalyzed Dynamic Kinetic Resolution of Tetrahydro-β-carbolines8 Conclusion and Perspectives

scholarly journals Nickel-catalyzed asymmetric transfer hydrogenation of conjugated olefins

2015 ◽  
Vol 51 (60) ◽  
pp. 12115-12117 ◽  
Author(s):  
Siyu Guo ◽  
Peng Yang ◽  
Jianrong (Steve) Zhou
Keyword(s):  
Formic Acid ◽  
Nickel Catalyst ◽  
Asymmetric Hydrogenation ◽  
Transfer Hydrogenation ◽  
Asymmetric Transfer Hydrogenation

A nickel catalyst is used for asymmetric hydrogenation of electron-deficient olefins using formic acid as hydrogen source.

Asymmetric Hydrogenation of Trifluoromethyl Ketones: Application in the Synthesis of Odanacatib and LX-1031

2021 ◽  
Author(s):  
Tiao-Zhen Zhu ◽  
Pan-Lin Shao ◽  
Xumu Zhang
Keyword(s):  
Asymmetric Hydrogenation ◽  
Transfer Hydrogenation ◽  
Asymmetric Transfer Hydrogenation ◽  
Tridentate Ligands ◽  
Iridium Catalysis ◽  
Trifluoromethyl Ketones ◽  
Stereoelectronic Properties

Due to their stereoelectronic properties, trifluoromethyl (or perfluoroalkyl) ketones are challenging substrates in asymmetric (transfer) hydrogenation. We developed iridium catalysis bearing ferrocene-based tridentate ligands (f-amphol or f-ampha), offering a promising...

Mechanisms of the H2- and transfer hydrogenation of polar bonds catalyzed by iron group hydrides

2018 ◽  
Vol 47 (32) ◽  
pp. 10809-10826 ◽  
Author(s):  
Robert H. Morris
Keyword(s):  
Asymmetric Hydrogenation ◽  
Transfer Hydrogenation ◽  
Iron Group

This Perspective describes the mechanism-based development of iron-group catalysts for the asymmetric hydrogenation of ketones and imines.

Towards a Zinc-Catalyzed Asymmetric Hydrogenation/Transfer Hydrogenation of Imines

2012 ◽  
Vol 7 (11) ◽  
pp. 2562-2568 ◽  
Author(s):  
Svenja Werkmeister ◽  
Steffen Fleischer ◽  
Kathrin Junge ◽  
Matthias Beller
Keyword(s):  
Asymmetric Hydrogenation ◽  
Transfer Hydrogenation
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