Synthesis of New Heterocyclic Systems: Pyrido[3′,2′:4,5]thieno(furo)[2,3-e ][1,2,4]triazolopyrimidines and an Unusual ANRORC Rearrangement in the Fused Pyrimidine Series

2018 ◽  
Vol 3 (39) ◽  
pp. 10938-10942 ◽  
Author(s):  
Samvel N. Sirakanyan ◽  
Domenico Spinelli ◽  
Athina Geronikaki ◽  
Viktor G. Kartsev ◽  
Elmira K. Hakobyan ◽  
...  
Keyword(s):  
Pyrimidine Series ◽  
Anrorc Rearrangement

New reaction in pyrimidine series

1984 ◽  
Vol 20 (12) ◽  
pp. 1399-1399
Author(s):  
T. V. Stupnikova ◽  
T. V. Nuzhnaya ◽  
N. A. Klyuev
Keyword(s):  
Pyrimidine Series

Pyridopyrimidines. 6. Nucleophilic substitutions in the pyrido[2,3-d]pyrimidine series

1977 ◽  
Vol 42 (6) ◽  
pp. 993-996 ◽  
Author(s):  
Gary L. Anderson ◽  
Jaewon L. Shim ◽  
Arthur D. Broom
Keyword(s):  
Nucleophilic Substitutions ◽  
Pyrimidine Series

ChemInform Abstract: σ-Complexes in the Pyrimidine Series. Part 11. 5-Arylazo-5-nitro- 2,5- and -4,5-dihydropyrimidines from Anionic σ-Complexes of 5- Nitropyrimidine.

ChemInform ◽  
2010 ◽  
Vol 25 (5) ◽  
pp. no-no
Author(s):  
G. YA. REMENNIKOV ◽  
S. G. VISHNEVSKII ◽  
V. V. PIROZHENKO ◽  
S. I. VDOVENKO ◽  
V. M. CHERKASOV ◽  
...  
Keyword(s):  
Pyrimidine Series

Synthesis of functionalized amides of 2-(arylamino)pyrimidine series

2017 ◽  
Vol 53 (2) ◽  
pp. 251-257 ◽  
Author(s):  
Zh. V. Ignatovich ◽  
E. V. Koroleva
Keyword(s):  
Pyrimidine Series

Antibacterial activity of synthetic pyrido[2,3-d]pyrimidines armed with nitrile groups: POM analysis and identification of pharmacophore sites of nitriles as important pro-drugs

2018 ◽  
Vol 42 (19) ◽  
pp. 15610-15617 ◽  
Author(s):  
Rajendra Sukhdeorao Dongre ◽  
Jyostna S. Meshram ◽  
Rupali Sudhakarrao Selokar ◽  
Faisal A. Almalki ◽  
Taibi Ben Hadda
Keyword(s):  
Antibacterial Activity ◽  
Bacterial Strains ◽  
Inhibitory Effects ◽  
Pyrimidine Series

A pyrido[2,3-d]pyrimidine series has exhibited inhibitory effects on the growth of bacterial strains.

scholarly journals STUDIES OF THE MECHANISM OF ACTION OF URETHANE IN INITIATING PULMONARY ADENOMAS IN MICE

1957 ◽  
Vol 105 (4) ◽  
pp. 279-306 ◽  
Author(s):  
Stanfield Rogers
Keyword(s):  
Nucleic Acid ◽  
Orotic Acid ◽  
Acid Synthesis ◽  
Nucleic Acid Synthesis ◽  
Inhibitory Influence ◽  
Single Exposure ◽  
Carcinogenic Effect ◽  
Pyrimidine Series ◽  
Carcinogenic Action ◽  
Primary Disorder

The process of carcinogenesis following exposure of mice to urethane is demonstrated in the present work to be intimately related to nucleic acid synthesis. Injection of animals with a DNA hydrolysate immediately prior to a single exposure of the animals to urethane markedly reduced the number of pulmonary adenomas initiated. Aminopterin, known to interfere in nucleic acid synthesis (46), potentiated the carcinogenic action of urethane and this potentiation was blocked by injection of a DNA hydrolysate. Of the components and precursors of nucleic acids the pyrimidine series seemed especially concerned. Alterations in the utilization of oxaloacetate, ureidosuccinic acid, dihydro-orotic acid, orotic acid, cytidylic acid, and thymine appeared to be critical steps in the oncogenic process, following upon the primary disorder of cellular metabolism initiated by the carcinogen. All these substances except oxaloacetate profoundly reduced the number of tumors initiated by urethane. Oxaloacetate potentiated the carcinogenic effect. When these results are viewed together and in relation to known facts concerning nucleic acid synthesis they provide evidence suggesting that the point of action of the carcinogen is in the pathway of nucleic acid synthesis below orotic acid and perhaps at the level of ureidosuccinic acid. The potentiating influence of adenine, 4-amino-5-imidazole carboxamide, and aminopterin, the lack of effect of uracil, and the inhibitory influence of thymine together suggest that DNA rather than RNA is the nucleic acid critical to the oncogenic response of mice to urethane.

scholarly journals Synthesis of Compounds of the Pyrimidine Series Based on the Reactions of 3-Arylmethylidenefuran-2(3H)-ones with N,N-Binucleophilic Reagents

Molecules ◽  
2017 ◽  
Vol 22 (8) ◽  
pp. 1251 ◽  
Author(s):  
Tatyana Aniskova ◽  
Vyacheslav Grinev ◽  
Alevtina Yegorova
Keyword(s):  
Pyrimidine Series

Synthesis of 2-Deoxy-β-D-ribonucleosides and 2,3-Dideoxy-β-D-pentofuranosides on Immobilized Bacterial Cells

1994 ◽  
Vol 59 (10) ◽  
pp. 2303-2330 ◽  
Author(s):  
Ivan Votruba ◽  
Antonín Holý ◽  
Hana Dvořáková ◽  
Jaroslav Günter ◽  
Dana Hocková ◽  
...  
Keyword(s):  
The Other ◽  
Bacterial Cells ◽  
Amino Groups ◽  
E Coli ◽  
Pyrimidine Series ◽  
Acceptor Activity ◽  
Dependent Strain ◽  
Pyrimidine Bases ◽  
Heterocyclic Bases ◽  
Derivatives Of

Alginate gel-entrapped cells of auxotrophic thymine-dependent strain of E. coli catalyze the transfer of 2-deoxy-D-ribofuranosyl moiety of 2'-deoxyuridine to purine and pyrimidine bases as well as their aza and deaza analogs. All experiments invariably gave β-anomers; in most cases, the reaction was regiospecific, affording N9-isomers in the purine and N1-isomers in the pyrimidine series. Also a 2,3-dideoxynucleoside can serve as donor of the glycosyl moiety. The acceptor activity of purine bases depends only little on substitution, the only condition being the presence of N7-nitrogen atom. On the other hand, in the pyrimidine series the activity is limited to only a narrow choice of mostly short 5-alkyl and 5-halogeno uracil derivatives. Heterocyclic bases containing amino groups are deaminated; this can be avoided by conversion of the base to the corresponding N-dimethylaminomethylene derivative which is then ammonolyzed. The method was verified by isolation of 9-(2-deoxy-β-D-ribofuranosyl) derivatives of adenine, guanine, 2-chloroadenine, 6-methylpurine, 8-azaadenine, 8-azaguanine, 1-deazaadenine, 3-deazaadenine, 1-(2-deoxy-β-D-ribofuranosyl) derivatives of 5-ethyluracil, 5-fluorouracil, and 9-(2,3-dideoxy-β-D-pentofuranosyl)hypoxanthine, 9-(2,3-dideoxy-β-D-pentofuranosyl)-6-methylpurine, and other nucleosides.

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