In Vitro Anticancer Drug Delivery Using Amphiphilic Poly(N -vinylpyrrolidone)-b -Polyketal-b -Poly(N -vinylpyrrolidone) Block Copolymer as Micellar Nanocarrier

2018 ◽  
Vol 3 (31) ◽  
pp. 8833-8843 ◽  
Author(s):  
Kheyanath Mitra ◽  
Sumit Kumar Hira ◽  
Shikha Singh ◽  
Niraj Kumar Vishwakarma ◽  
Sambhav Vishwakarma ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Anticancer Drug ◽  
Anticancer Drug Delivery

scholarly journals Corrigendum: In Vitro Anticancer Drug Delivery Using Amphiphilic Poly( N ‐vinylpyrrolidone)‐ b ‐Polyketal‐ b ‐Poly( N ‐vinylpyrrolidone) Block Copolymer as Micellar Nanocarrier

2019 ◽  
Vol 4 (40) ◽  
pp. 11851-11851
Author(s):  
Kheyanath Mitra ◽  
Sumit Kumar Hira ◽  
Shikha Singh ◽  
Niraj Kumar Vishwakarma ◽  
Sambhav Vishwakarma ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Anticancer Drug ◽  
Anticancer Drug Delivery

A block copolymer of zwitterionic polyphosphoester and polylactic acid for drug delivery

2015 ◽  
Vol 3 (7) ◽  
pp. 1105-1113 ◽  
Author(s):  
Rong Sun ◽  
Xiao-Jiao Du ◽  
Chun-Yang Sun ◽  
Song Shen ◽  
Yang Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Block Copolymers ◽  
Ethylene Glycol ◽  
Polylactic Acid ◽  
Anticancer Drug ◽  
Poly Ethylene Glycol ◽  
Anticancer Drug Delivery ◽  
Poly Ethylene

Zwitterionic polyphosphoester containing polymers are synthesized and evaluated as an alternative to poly(ethylene glycol) block copolymers for anticancer drug delivery.

Facile construction of stabilized, pH-sensitive micelles based on cyclic statistical copolymers of poly(oligo(ethylene glycol)methyl ether methacrylate-st-N,N-dimethylaminoethyl methacrylate) for in vitro anticancer drug delivery

2020 ◽  
Vol 11 (38) ◽  
pp. 6139-6148
Author(s):  
Miao Zhang ◽  
Ying Liu ◽  
Jinlei Peng ◽  
Yuping Liu ◽  
Fangjun Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Anticancer Drug ◽  
Methyl Ether ◽  
Colloidal Stability ◽  
Ph Sensitive ◽  
Anticancer Drug Delivery ◽  
Dimethylaminoethyl Methacrylate ◽  
Glycol Methyl Ether

This study developed a facile approach to improve the colloidal stability of a cyclic polycation as well as presented a pH-sensitive cyclic copolymer-based nanoplatform with great potential for anticancer drug delivery.

Poly(2-oxazoline)–Pterostilbene Block Copolymer Nanoparticles for Dual-Anticancer Drug Delivery

2017 ◽  
Vol 19 (1) ◽  
pp. 103-111 ◽  
Author(s):  
Matteo Romio ◽  
Giulia Morgese ◽  
Lucca Trachsel ◽  
Samuel Babity ◽  
Cristina Paradisi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Anticancer Drug ◽  
Anticancer Drug Delivery

Simultaneously Photo-Cleavable and Activatable Prodrug-Backboned Block Copolymer Micelles for Precise Anticancer Drug Delivery

2016 ◽  
Vol 5 (19) ◽  
pp. 2493-2499 ◽  
Author(s):  
Dongfang Zhou ◽  
Jinshan Guo ◽  
Gloria B. Kim ◽  
Jizhen Li ◽  
Xuesi Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Anticancer Drug ◽  
Anticancer Drug Delivery ◽  
Block Copolymer Micelles ◽  
Copolymer Micelles

Poly(N-isopropylacrylamide)-b-Poly(L-lysine)-b-Poly(L-histidine) Triblock Amphiphilic Copolymer Nanomicelles for Dual-Responsive Anticancer Drug Delivery

2020 ◽  
Vol 20 (11) ◽  
pp. 6959-6967
Author(s):  
Rimesh Augustine ◽  
Dae-Kyoung Kim ◽  
Ho An Kim ◽  
Jae Ho Kim ◽  
Il Kim
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Drug Loading ◽  
Anticancer Drug Delivery ◽  
Dual Responsive ◽  
Micellar Aggregates ◽  
Reversible Addition ◽  
Hydrogen Carbonate ◽  
Copolymer Micelle

A series of ABC triblock poly(N-isopropylacrylamide)75-block-poly(L-lysine)35-block-poly(L-histidine)n (p(NIPAM)75-b-p(Lys)35-b-p(His)N) (N = 35,50,75,100) copolymer bio-conjugates were prepared by combining reversible addition-fragmentation chain transfer polymerization and fast ring-opening polymerization of N-carboxyanhydride a-amino acid using 1,3-dicyclohexylimidazolium hydrogen carbonate as a catalyst. All the resulting triblock copolymers self-assembled into spherical micellar aggregates in aqueous solution, irrespective of the chain length of the histidine block. The micellar aggregates encapsulated the anticancer drug doxorubicin (Dox) and exhibited high drug loading efficiency. Temperature and pH stimuli were applied to investigate the controlled release of Dox. The non-cytotoxic nature of the polymers was investigated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Cellular uptake of the Dox-loaded micelles revealed that the micelles successfully release Dox in cancer cells in response to pH- and temperature-induced morphological change. In-vitro studies further confirmed that the Dox-loaded triblock copolymer micelle is an excellent platform for drug delivery.

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