MCM-41-Supported Linear Alkylamine-Catalyzed In Situ Generation of Unstable Trifluoroacetaldehyde and Successive syn -Selective Direct Aldol Reaction with Cyclic Ketones

2017 ◽  
Vol 2 (23) ◽  
pp. 6673-6682
Author(s):  
Kazumasa Funabiki ◽  
Hideyuki Nagaya ◽  
Hiroshi Gonda ◽  
Yuta Sakaida ◽  
Yasuhiro Kubota ◽  
...  
Keyword(s):  
Aldol Reaction ◽  
Cyclic Ketones ◽  
Direct Aldol Reaction ◽  
In Situ Generation ◽  
Mcm 41

Cinchonine-catalyzed in situ generation of unstable and gaseous trifluoroacetaldehyde from its hemiacetal and direct aldol reaction with 2-methoxy-1-phenylethanone

2017 ◽  
Vol 198 ◽  
pp. 76-81 ◽  
Author(s):  
Kazumasa Funabiki ◽  
Yosuke Yano ◽  
Ayaka Hayakawa ◽  
Toshiyasu Inuzuka ◽  
Yasuhiro Kubota ◽  
...  
Keyword(s):  
Aldol Reaction ◽  
Direct Aldol Reaction ◽  
In Situ Generation

In situ generation of less accessible Boc-imines from aldehydes: construction of a quaternary carbon by the Mannich reaction or unprecedented aldol reaction

2017 ◽  
Vol 15 (21) ◽  
pp. 4527-4530 ◽  
Author(s):  
Taichi Kano ◽  
Chihiro Homma ◽  
Keiji Maruoka
Keyword(s):  
Mannich Reaction ◽  
Aldol Reaction ◽  
Quaternary Carbon ◽  
Mannich Reactions ◽  
The Mannich Reaction ◽  
In Situ Generation

Mannich reactions of β-dicarbonyls with in situ generated less accessible Boc-imines from aldehydes were achieved.

Highly diastereo- and enantioselective organocatalytic synthesis of trifluoromethylated erythritols based on the in situ generation of unstable trifluoroacetaldehyde

2021 ◽  
Author(s):  
Kazumasa Funabiki ◽  
Toshiya Gotoh ◽  
Ryunosuke Kani ◽  
Toshiyasu Inuzuka ◽  
Yasuhiro Kubota
Keyword(s):  
Trifluoromethyl Group ◽  
In Situ Generation

A highly diastereo- and enantioselective organocatalytic method to synthesise erythritols bearing a trifluoromethyl group has been investigated.

Recent advances in Minisci-type reactions and applications in organic synthesis

2020 ◽  
Vol 24 ◽  
Author(s):  
Wengui Wang ◽  
Shoufeng Wang
Keyword(s):  
Free Radical ◽  
Hydrogen Atom ◽  
Organic Synthesis ◽  
Radical Reactivity ◽  
Atom Loss ◽  
Radical Generation ◽  
In Situ Generation ◽  
Thermal Cleavage ◽  
Synthetic Chemist

Abstract:: Minisci-type reactions have become widely known as reactions that involve the addition of carbon-centered radicals to basic heteroarenes followed by formal hydrogen atom loss. While the originally developed protocols for radical generation remain in active use today, in recent years by a new array of radical generation strategies allow use of a wider variety of radical precursors that often operate under milder and more benign conditions. New transformations based on free radical reactivity are now available to a synthetic chemist looking to utilize a Minisci-type reaction. Radical-generation methods based on photoredox catalysis and electrochemistry, which utilize thermal cleavage or the in situ generation of reactive radical precursors, have become popular approaches. Our review will cover the remarkably literature that has appeared on this topic in recent 5 years, from 2015-01 to 2020-01, in an attempt to provide guidance to the synthetic chemist, on both the challenges that have been overcome and applications in organic synthesis.

scholarly journals A residue-free approach to water disinfection using catalytic in situ generation of reactive oxygen species

2021 ◽  
Author(s):  
Thomas Richards ◽  
Jonathan H. Harrhy ◽  
Richard J. Lewis ◽  
Alexander G. R. Howe ◽  
Grzegorz M. Suldecki ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Water Disinfection ◽  
Oxygen Species ◽  
In Situ Generation

In Situ Generation of Unstable Difluoromethylphosphonate-Containing Diazoalkanes and Their Use in [3 + 2] Cycloaddition Reactions with Vinyl Sulfones

2021 ◽  
Vol 23 (3) ◽  
pp. 1130-1134
Author(s):  
Haibo Mei ◽  
Li Wang ◽  
Romana Pajkert ◽  
Qian Wang ◽  
Jingcheng Xu ◽  
...  
Keyword(s):  
Cycloaddition Reactions ◽  
In Situ Generation
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