NMI/MsCl-Mediated Amide Bond Formation of Aminopyrazines and Aryl/Heteroaryl Carboxylic Acids: Synthesis of Biologically Relevant Pyrazine Carboxamides.

2017 ◽  
Vol 2 (25) ◽  
pp. 7706-7710 ◽  
Author(s):  
Nagaraja Reddy Gangarapu ◽  
Eeda Koti Reddy ◽  
Ayyiliath M Sajith ◽  
Shivaraj Yellappa ◽  
Kothapalli Bannoth Chandrasekhar
Keyword(s):  
Carboxylic Acids ◽  
Bond Formation ◽  
Amide Bond ◽  
Biologically Relevant ◽  
Amide Bond Formation

A computational study on the mechanism of ynamide-mediated amide bond formation from carboxylic acids and amines

2017 ◽  
Vol 15 (30) ◽  
pp. 6367-6374 ◽  
Author(s):  
Song-Lin Zhang ◽  
Hai-Xing Wan ◽  
Zhu-Qin Deng
Keyword(s):  
Reaction Mechanism ◽  
Carboxylic Acids ◽  
Computational Study ◽  
Bond Formation ◽  
Amide Bond ◽  
Reactivity Pattern ◽  
Amide Bond Formation ◽  
Coupling Reagent ◽  
Catalytic Effects ◽  
Acid Substrate

A detailed computational study is presented on the reaction mechanism of ynamide-mediated condensation of carboxylic acids with amines to produce amides, which elucidates the reactivity pattern of the coupling reagent ynamide and discloses crucial bifunctional catalytic effects of the carboxylic acid substrate during aminolysis.

Mechanism of Amide Bond Formation from Carboxylic Acids and Amines Promoted by 9-Silafluorenyl Dichloride Derivatives

2017 ◽  
Vol 82 (17) ◽  
pp. 9087-9096 ◽  
Author(s):  
Yuan-Ye Jiang ◽  
Ling Zhu ◽  
Yujie Liang ◽  
Xiaoping Man ◽  
Siwei Bi
Keyword(s):  
Carboxylic Acids ◽  
Bond Formation ◽  
Amide Bond ◽  
Amide Bond Formation

scholarly journals Poly(methylhydrosiloxane) as a green reducing agent in organophosphorus-catalysed amide bond formation

2017 ◽  
Vol 15 (30) ◽  
pp. 6426-6432 ◽  
Author(s):  
Daan F. J. Hamstra ◽  
Danny C. Lenstra ◽  
Tjeu J. Koenders ◽  
Floris P. J. T. Rutjes ◽  
Jasmin Mecinović
Keyword(s):  
Carboxylic Acids ◽  
Phosphine Oxide ◽  
Bond Formation ◽  
Reducing Agent ◽  
Amide Bond ◽  
Amide Bond Formation ◽  
Amidation Reaction

In situ reduction of phosphine oxide by poly(methylhydrosiloxane) leads to efficient amidation reaction between carboxylic acids and amines.

ChemInform Abstract: Solvent-Free Protocol for Amide Bond Formation via Trapping of Nascent Phosphazenes with Carboxylic Acids.

ChemInform ◽  
2011 ◽  
Vol 42 (37) ◽  
pp. no-no
Author(s):  
Murugan Sathishkumar ◽  
Poovan Shanmugavelan ◽  
Sangaraiah Nagarajan ◽  
Murugesan Maheswari ◽  
Murugan Dinesh ◽  
...  
Keyword(s):  
Carboxylic Acids ◽  
Bond Formation ◽  
Solvent Free ◽  
Amide Bond ◽  
Amide Bond Formation

Diphenylsilane as a coupling reagent for amide bond formation

2017 ◽  
Vol 19 (21) ◽  
pp. 5060-5064 ◽  
Author(s):  
Morgane Sayes ◽  
André B. Charette
Keyword(s):  
Carboxylic Acids ◽  
Bond Formation ◽  
Direct Coupling ◽  
Amide Bond ◽  
Amide Bond Formation ◽  
Coupling Reagent

A simple amidation procedure enabling the direct coupling of carboxylic acids to amines using one equivalent of diphenysilane is reported.

Fast TiO2-catalyzed direct amidation of neat carboxylic acids under mild dielectric heating

2014 ◽  
Vol 4 (5) ◽  
pp. 1395-1399 ◽  
Author(s):  
E. Calcio Gaudino ◽  
D. Carnaroglio ◽  
M. A. G. Nunes ◽  
L. Schmidt ◽  
E. M. M. Flores ◽  
...  
Keyword(s):  
Carboxylic Acids ◽  
Bond Formation ◽  
Academic Research ◽  
Amide Bond ◽  
Dielectric Heating ◽  
Amide Bond Formation ◽  
Important Challenge ◽  
Pharmaceutical Industries ◽  
Direct Amidation

The development of green protocols for amide bond formation is a major socioeconomic goal for chemical and pharmaceutical industries and an important challenge for academic research.

ChemInform Abstract: Copper-Catalyzed Amide Bond Formation from Formamides and Carboxylic Acids.

ChemInform ◽  
2015 ◽  
Vol 46 (22) ◽  
pp. no-no
Author(s):  
Hong-Qiang Liu ◽  
Jun Liu ◽  
Yang-Hui Zhang ◽  
Chang-Dong Shao ◽  
Jing-Xun Yu
Keyword(s):  
Carboxylic Acids ◽  
Bond Formation ◽  
Amide Bond ◽  
Amide Bond Formation

ChemInform Abstract: Triphenylphosphine-Catalyzed Amide Bond Formation Between Carboxylic Acids and Amines.

ChemInform ◽  
2014 ◽  
Vol 45 (38) ◽  
pp. no-no
Author(s):  
Danny C. Lenstra ◽  
Floris P. J. T. Rutjes ◽  
Jasmin Mecinovic
Keyword(s):  
Carboxylic Acids ◽  
Bond Formation ◽  
Amide Bond ◽  
Amide Bond Formation
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