PEG-400 Mediated an Efficient Green Synthesis of Isoxazolyl Indole-3-Carboxylic Acid Esters via Nentizescu Condensation Reaction and Their Anti-Inflammatory and Analgesic Activity

2017 ◽  
Vol 2 (18) ◽  
pp. 5110-5114 ◽  
Author(s):  
Nagaraju Dharavath ◽  
Rajanarendar Eligeti ◽  
Y N Reddy ◽  
Praveen Kumar Pittala ◽  
Nagi Reddy Modugu
Keyword(s):  
Carboxylic Acid ◽  
Green Synthesis ◽  
Analgesic Activity ◽  
Condensation Reaction ◽  
Peg 400 ◽  
Anti Inflammatory ◽  
Acid Esters

scholarly journals Green Synthesis and Antimicrobial Activity of Some Novel N-Arylimidazo[1,2-a]pyrazine-2-Carboxamide Derivatives

2019 ◽  
Vol 32 (1) ◽  
pp. 84-90 ◽  
Author(s):  
Boggavarapu Jyothi ◽  
Nannapaneni Madhavi
Keyword(s):  
Antimicrobial Activity ◽  
Carboxylic Acid ◽  
Microwave Irradiation ◽  
Green Synthesis ◽  
13C Nmr ◽  
Aromatic Amines ◽  
Condensation Reaction ◽  
Analytical Data ◽  
Ammonia Gas ◽  
1H And 13C Nmr

The article deals with the synthesis of some novel N-arylimidazo[1,2-a]pyrazine-2-carboxamides (7a-l) by condensation reaction of imidazo[1,2-a]pyrazine-2-carboxylic acid (5) with different aliphatic/aromatic amines (6a-l) by using 1-methylimidazole, Mukaiyama’s reagent and 2-chloro-1-methylpyridinium iodide under microwave irradiation conditions. A new series of compounds 7 have been prepared from 2-iodopyrazine (1). Compound 1 on purged with ammonia gas in the presence of Cu2O and K2CO3 furnishes pyrazin-2-amine (2), which is treated with ethyl 3-bromo-2-oxopropanoate (3) to produce ethyl imidazo[1,2-a]pyrazine-2-carboxylate (4), which on hydrolysis with NaOH yields imidazo[1,2-a]pyrazine-2-carboxylic acid (5). The structures of the newly synthesized compounds have been elucidated on the basis of spectral (IR, 1H and 13C NMR and MS) and analytical data. Compounds 7a-l have also been screened for their antimicrobial activity. Some of the compounds exhibit promising antimicrobial activity

scholarly journals Green Synthesis of Acid Esters from Furfural via Stobbe Condensation

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Shubhra Banerjee ◽  
Ravibabu A. Tayade ◽  
Bhagyashree D. Sharma
Keyword(s):  
Green Synthesis ◽  
Acid Ester ◽  
Room Temperature ◽  
Condensation Reaction ◽  
Dicarboxylic Acids ◽  
Solvent Free ◽  
Butenoic Acid ◽  
Acid Esters ◽  
Dimethyl Succinate

Solvent-free Stobbe condensation of furfural1with dimethyl succinate2under anhydrous conditions at room temperature using dry-solid potassium tertiary butoxide gave 3-carbomethoxy, 4-furyl-3-butenoic acid3, which upon methylation followed by Stobbe condensation reaction with different aldehydes and/or ketones under anhydrous conditions at room temperature afforded substituted carbomethoxy acids5a–f. These acid ester products were saponified to the corresponding dicarboxylic acids6a–fwhich are useful in the synthesis of photochromic fulgides.

PEG-400 mediated an efficient eco-friendly synthesis of new isoxazolyl pyrido[2,3-d]pyrimidines and their anti-inflammatory and analgesic activity

2020 ◽  
Vol 50 (19) ◽  
pp. 2950-2961
Author(s):  
Srinivasa Rao Dasari ◽  
Subbaiah Tondepu ◽  
Lakshmana Rao Vadali ◽  
Nareshvarma Seelam
Keyword(s):  
Analgesic Activity ◽  
Peg 400 ◽  
Anti Inflammatory

Anti-inflammatory and analgesic activity of Jateorhiza macrantha (Menispermaceae)

Planta Medica ◽  
2013 ◽  
Vol 79 (13) ◽  
Author(s):  
GO Ajayi ◽  
O Salako ◽  
IM Mosebolatan
Keyword(s):  
Analgesic Activity ◽  
Anti Inflammatory

Anti-inflammatory and analgesic activity of Memecylon edule Roxb

Planta Medica ◽  
2007 ◽  
Vol 73 (09) ◽  
Author(s):  
S Nualkaew ◽  
S Thongpraditchote ◽  
Y Wongkrajang ◽  
K Rattanamanee
Keyword(s):  
Analgesic Activity ◽  
Anti Inflammatory

Ketones from Nickel-Catalyzed Decarboxylative, Non-Symmetric Cross-Electrophile Coupling of Carboxylic Acid Esters

2019 ◽  
Author(s):  
Jiang Wang ◽  
Brian P. Cary ◽  
Peyton Beyer ◽  
Samuel H. Gellman ◽  
Daniel Weix
Keyword(s):  
Carboxylic Acid ◽  
Solid Support ◽  
Reaction Conditions ◽  
Decarboxylative Coupling ◽  
New Strategy ◽  
The Cross ◽  
Acyl Donors ◽  
Acid Esters

A new strategy for the synthesis of ketones is presented based upon the decarboxylative coupling of N-hydroxyphthalimide (NHP) esters with S-2-pyridyl thioesters. The reactions are selective for the cross-coupled product because NHP esters act as radical donors and the thioesters act as acyl donors. The reaction conditions are general and mild, with over 40 examples presented, including larger fragments and the 20-mer peptide Exendin(9-39) on solid support.

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