Towards the Synthesis of New Tumor Targeting Photosensitizers for Photodynamic Therapy and Imaging Applications

2017 ◽  
Vol 2 (1) ◽  
pp. 190-200 ◽  
Author(s):  
Giuliana Mion ◽  
Cristina Mari ◽  
Tatiana Da Ros ◽  
Riccardo Rubbiani ◽  
Gilles Gasser ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Targeting

scholarly journals Enzyme-Loaded Catalytic Macrophage Vesicles with Cascade Amplification of Tumor-Targeting for Oxygenated Photodynamic Therapy

2021 ◽  
Vol Volume 16 ◽  
pp. 7801-7812
Author(s):  
Ling Liu ◽  
Jiayu Zhang ◽  
Zinan Li ◽  
Yang Yang ◽  
Longyun Li ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Targeting ◽  
Cascade Amplification

scholarly journals Chlorin e6-Biotin Conjugates for Tumor-Targeting Photodynamic Therapy

Molecules ◽  
2021 ◽  
Vol 26 (23) ◽  
pp. 7342
Author(s):  
Wei Liu ◽  
Xingqun Ma ◽  
Yingying Jin ◽  
Jie Zhang ◽  
Yang Li ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Hela Cells ◽  
Tumor Targeting ◽  
Laser Scanning ◽  
Water Solubility ◽  
Laser Scanning Microscopy ◽  
Chlorin E6 ◽  
Confocal Laser ◽  
Oxygen Generation ◽  
Targeting Ability

To improve the tumor-targeting efficacy of photodynamic therapy, biotin was conjugated with chlorin e6 to develop a new tumor-targeting photosensitizer, Ce6-biotin. The Ce6-biotin had good water solubility and low aggregation. The singlet-oxygen generation rate of Ce6-biotin was slightly increased compared to Ce6. Flow cytometry and confocal laser scanning microscopy results confirmed Ce6-biotin had higher binding affinity toward biotin-receptor-positive HeLa human cervical carcinoma cells than its precursor, Ce6. Due to the BR-targeting ability of Ce6-biotin, it exhibited stronger cytotoxicity to HeLa cells upon laser irradiation. The IC50 against HeLa cells of Ce6-biotin and Ce6 were 1.28 µM and 2.31 µM, respectively. Furthermore, both Ce6-biotin and Ce6 showed minimal dark toxicity. The selectively enhanced therapeutic efficacy and low dark toxicity suggest that Ce6-biotin is a promising PS for BR-positive-tumor-targeting photodynamic therapy.

scholarly journals Binary organic nanoparticles with enhanced reactive oxygen species generation capability for photodynamic therapy

2021 ◽  
pp. 2150009
Author(s):  
Xiaofu Weng ◽  
Zhouzhou Bao ◽  
Xunbin Wei
Keyword(s):  
Reactive Oxygen Species ◽  
Photodynamic Therapy ◽  
Tumor Targeting ◽  
Reactive Oxygen Species Generation ◽  
Reactive Oxygen ◽  
Ros Generation ◽  
Oxygen Species ◽  
Enhanced Fluorescence ◽  
New Strategy ◽  
Biological Environment

Photodynamic therapy (PDT) takes advantage of photosensitizers (PSs) to generate reactive oxygen species (ROS) for cell killing when excited by light. It has been widely used in clinic for therapy of multiple cancers. Currently, all the FDA-approved PSs, including porphyrin, are all small organic molecules, suffering from aggregation-caused quenching (ACQ) issues in biological environment and lacking tumor targeting capability. Nanoparticles (NPs) with size between 20[Formula: see text]nm and 200[Formula: see text]nm possess tumor targeting capability due to the enhanced permeability and retention (EPR) effect. It is urgent to develop a new strategy to form clinical-approved-PSs-based NPs with improved ROS generation capability. In this study, we report a strategy to overwhelm the ACQ of porphyrin by doping it with a type of aggregation-induced emission (AIE) luminogen to produce a binary NPs with high biocompatibility, and enhanced fluorescence and ROS generation capability. Such NPs can be readily synthesized by mixing a porphyrin derivative, Ce6 with a typical AIE luminogen, TPE-Br. Here, our experimental results have demonstrated the feasibility and effectiveness of this strategy, endowing it a great potential in clinical applications.

Tumor-targeting and imaging micelles for pH-triggered anticancer drug release and combined photodynamic therapy

2020 ◽  
Vol 31 (11) ◽  
pp. 1385-1404 ◽  
Author(s):  
Qianqian Qi ◽  
Xianwu Zeng ◽  
Licong Peng ◽  
Hailiang Zhang ◽  
Miao Zhou ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Drug Release ◽  
Anticancer Drug ◽  
Tumor Targeting

Anti-HER2 Affibody-Conjugated Photosensitizer for Tumor Targeting Photodynamic Therapy

2020 ◽  
Vol 17 (5) ◽  
pp. 1546-1557 ◽  
Author(s):  
Shuang Li ◽  
Yingying Jin ◽  
Yao Su ◽  
Wenjing Li ◽  
Yutong Xing ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Targeting
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