Transition-Metal-Free Direct Synthesis of Tetra- and Pentacyclic Azaheteroarenes via [3+3] Annulation of Nitroarenes and Benzyl-Type Carbanions Mediated by Silylating Agents.

2016 ◽  
Vol 1 (15) ◽  
pp. 4886-4890 ◽  
Author(s):  
Michał Nowacki ◽  
Krzysztof Wojciechowski
Keyword(s):  
Transition Metal ◽  
Direct Synthesis ◽  
Metal Free ◽  
Silylating Agents

A cascade process for the synthesis of ortho-formyl allyl aryl ethers and 2H-chromen-2-ol derivatives from arynes via trapping of o-quinone methide with an activated alkene

2019 ◽  
Vol 17 (2) ◽  
pp. 333-346 ◽  
Author(s):  
Abhilash Sharma ◽  
Pranjal Gogoi
Keyword(s):  
Transition Metal ◽  
Direct Synthesis ◽  
Quinone Methide ◽  
Cascade Process ◽  
Metal Free ◽  
Synthetic Strategy ◽  
Aryl Ethers ◽  
Three Component Coupling

A transition-metal free synthetic strategy for the direct synthesis of ortho-formyl substituted allyl aryl ethers and 2H-chromen-2-ol derivatives via a cascade three-component coupling of arynes, activated alkene and N,N-dimethylformamide.

scholarly journals Straightforward Strategies for the Preparation of NH-Sulfox­imines: A Serendipitous Story

Synlett ◽  
2017 ◽  
Vol 28 (19) ◽  
pp. 2525-2538 ◽  
Author(s):  
James Bull ◽  
Renzo Luisi ◽  
Leonardo Degennaro
Keyword(s):  
Transition Metal ◽  
Physicochemical Properties ◽  
Direct Synthesis ◽  
Transition Metal Catalysts ◽  
Hypervalent Iodine ◽  
Reaction Conditions ◽  
One Pot ◽  
Metal Free ◽  
Recent Developments ◽  
New Procedures

Sulfoximines are emerging as valuable new isosteres for use in medicinal chemistry, with the potential to modulate physicochemical properties. Recent developments in synthetic strategies have made the unprotected ‘free’ NH-sulfoximine group more readily available, facilitating further study. This account reviews approaches to NH-sulfoximines, with a focus on our contribution to the field. Starting from the development of catalytic strategies involving transition metals, more sustainable metal-free processes have been discovered. In particular, the use of hypervalent iodine reagents to mediate NH-transfer to sulfoxides is described, along with an assessment of the substrate scope. Furthermore, a one-pot strategy to convert sulfides directly into NH-sulfoximines is discussed, with N- and O-transfer occurring under the reaction conditions. Mechanistic evidence for the new procedures is included as well as relevant synthetic applications that further exemplify the potential of these approaches.1 Introduction2 Strategies to Form NH-Sulfoximines Involving Transition-Metal Catalysts3 Metal-Free Strategies to Prepare NH-Sulfoximines4 Mechanistic Evidence for the Direct Synthesis of NH-Sulfoximines from Sulfoxides and Sulfides5 Further Applications6 Conclusion

ChemInform Abstract: Diazo- and Transition-Metal-Free C-H Insertion: A Direct Synthesis of β-Lactams.

ChemInform ◽  
2015 ◽  
Vol 46 (24) ◽  
pp. no-no
Author(s):  
Luis F. R. Gomes ◽  
Luis F. Veiros ◽  
Nuno Maulide ◽  
Carlos A. M. Afonso
Keyword(s):  
Transition Metal ◽  
Direct Synthesis ◽  
Metal Free

Synthesis of 6-substituted indoloquinazolinones from arynes and 2-acyl-4-quinazolinones: a transition-metal free C–N and C–C bond formation strategy

2020 ◽  
Vol 44 (41) ◽  
pp. 17938-17953
Author(s):  
Abhilash Sharma ◽  
Pranjal Gogoi
Keyword(s):  
Transition Metal ◽  
Direct Synthesis ◽  
Bond Formation ◽  
Reaction Vessel ◽  
Metal Free ◽  
Synthetic Strategy ◽  
Single Reaction

A versatile transition-metal free synthetic strategy has been developed for the direct synthesis of 6-substituted indoloquinazolinones from 2-acyl-4-quinazolinones and aryne precursors. This cascade strategy proceeds via successive C–N and C–C bond formation in a single reaction vessel.

scholarly journals Back Cover: Diazo- and Transition-Metal-Free CH Insertion: A Direct Synthesis of β-Lactams (Chem. Eur. J. 4/2015)

2015 ◽  
Vol 21 (4) ◽  
pp. 1820-1820
Author(s):  
Luis F. R. Gomes ◽  
Luís F. Veiros ◽  
Nuno Maulide ◽  
Carlos A. M. Afonso
Keyword(s):  
Transition Metal ◽  
Direct Synthesis ◽  
Metal Free ◽  
Back Cover

Aryne insertion into the PO bond: one-pot synthesis of quaternary phosphonium triflates

2019 ◽  
Vol 17 (26) ◽  
pp. 6450-6460 ◽  
Author(s):  
Kashmiri Neog ◽  
Dhiraj Dutta ◽  
Babulal Das ◽  
Pranjal Gogoi
Keyword(s):  
Transition Metal ◽  
Phosphine Oxide ◽  
Direct Synthesis ◽  
One Pot ◽  
Metal Free ◽  
One Pot Synthesis ◽  
Synthetic Strategy

A novel transition-metal free synthetic strategy for the direct synthesis of quaternary phosphonium triflates via insertion of aryne into phosphine oxide.

Direct Synthesis of 2-Aryl-4-quinolones via Transition-Metal-Free Intramolecular Oxidative C(sp3)–H/C(sp3)–H Coupling

2015 ◽  
Vol 17 (5) ◽  
pp. 1268-1271 ◽  
Author(s):  
Wei Hu ◽  
Jian-Ping Lin ◽  
Li-Rui Song ◽  
Ya-Qiu Long
Keyword(s):  
Transition Metal ◽  
Direct Synthesis ◽  
Metal Free

Direct synthesis of N-arylamides via the coupling of aryl diazonium tetrafluoroborates and nitriles under transition-metal-free conditions

2018 ◽  
Vol 59 (32) ◽  
pp. 3139-3142 ◽  
Author(s):  
Biquan Xiong ◽  
Gang Wang ◽  
Tao Xiong ◽  
Liming Wan ◽  
Congshan Zhou ◽  
...  
Keyword(s):  
Transition Metal ◽  
Direct Synthesis ◽  
Metal Free

Direct synthesis of ortho-methylthio allyl and vinyl ethers via three component reaction of aryne, activated alkene and DMSO

2020 ◽  
Vol 18 (14) ◽  
pp. 2727-2738 ◽  
Author(s):  
Hemanta Hazarika ◽  
Pranjal Gogoi
Keyword(s):  
Transition Metal ◽  
Direct Synthesis ◽  
Vinyl Ethers ◽  
Metal Free ◽  
Synthetic Strategy ◽  
Three Component Reaction ◽  
Three Component Coupling

A transition-metal free synthetic strategy for the direct synthesis of ortho-methylthio allyl and vinyl ethers via cascade three-component coupling of aryne, activated alkene and DMSO.

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