A conditional autoregressive model for genetic association analysis accounting for genetic heterogeneity

2021 ◽  
Author(s):  
Xiaoxi Shen ◽  
Yalu Wen ◽  
Yuehua Cui ◽  
Qing Lu
Keyword(s):  
Genetic Association ◽  
Association Analysis ◽  
Genetic Heterogeneity ◽  
Autoregressive Model ◽  
Genetic Association Analysis ◽  
Conditional Autoregressive Model ◽  
Conditional Autoregressive

Genetic association analysis between IL9 and coronary artery disease in a Chinese Han population

Cytokine ◽  
2022 ◽  
Vol 150 ◽  
pp. 155761
Author(s):  
Lingfeng Zha ◽  
Jiangtao Dong ◽  
Qianwen Chen ◽  
Yuhua Liao ◽  
Hongsong Zhang ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Genetic Association ◽  
Association Analysis ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Genetic Association Analysis ◽  
Han Population ◽  
Artery Disease

scholarly journals Prevalence, Patterns, and Genetic Association Analysis of Modic Vertebral Endplate Changes

2017 ◽  
Vol 11 (4) ◽  
pp. 594-600 ◽  
Author(s):  
Rishi Mugesh Kanna ◽  
Rajasekaran Shanmuganathan ◽  
Veera Ranjani Rajagopalan ◽  
Senthil Natesan ◽  
Raveendran Muthuraja ◽  
...  
Keyword(s):  
Candidate Genes ◽  
Genetic Association ◽  
Association Analysis ◽  
Disc Degeneration ◽  
Lumbar Disc ◽  
Nucleotide Polymorphisms ◽  
Lumbar Disc Degeneration ◽  
Vertebral Endplate ◽  
Genetic Association Analysis ◽  
Study Population

<sec><title>Study Design</title><p>A prospective genetic association study.</p></sec><sec><title>Purpose</title><p>The etiology of Modic changes (MCs) is unclear. Recently, the role of genetic factors in the etiology of MCs has been evaluated. However, studies with a larger patient subset are lacking, and candidate genes involved in other disc degeneration phenotypes have not been evaluated. We studied the prevalence of MCs and genetic association of 41 candidate genes in a large Indian cohort.</p></sec><sec><title>Overview of Literature</title><p>MCs are vertebral endplate signal changes predominantly observed in the lumbar spine. A significant association between MCs and lumbar disc degeneration and nonspecific low back pain has been described, with the etiopathogenesis implicating various mechanical, infective, and biochemical factors.</p></sec><sec><title>Methods</title><p>We studied 809 patients using 1.5-T magnetic resonance imaging to determine the prevalence, patterns, distribution, and type of lumbar MCs. Genetic association analysis of 71 single nucleotide polymorphisms (SNPs) of 41 candidate genes was performed based on the presence or absence of MCs. SNPs were genotyped using the Sequenome platform, and an association test was performed using PLINK software.</p></sec><sec><title>Results</title><p>The mean age of the study population (n=809) was 36.7±10.8 years. Based on the presence of MCs, the cohort was divided into 702 controls and 107 cases (prevalence, 13%). MCs were more commonly present in the lower (149/251, 59.4%) than in the upper (102/251, 40.6%) endplates. L4–5 endplates were the most commonly affected levels (30.7%). Type 2 MCs were the most commonly observed pattern (n=206, 82%). The rs2228570 SNP of VDR (<italic>p</italic>=0.02) and rs17099008 SNP of MMP20 (<italic>p</italic>=0.03) were significantly associated with MCs.</p></sec><sec><title>Conclusions</title><p>Genetic polymorphisms of SNPs of VDR and MMP20 were significantly associated with MCs. Understanding the etiopathogenetic mechanisms of MCs is important for planning preventive and therapeutic strategies.</p></sec>

scholarly journals Bioinformatic and Genetic Association Analysis of MicroRNA Target Sites in One-Carbon Metabolism Genes

PLoS ONE ◽  
2011 ◽  
Vol 6 (7) ◽  
pp. e21851 ◽  
Author(s):  
Nicole Stone ◽  
Faith Pangilinan ◽  
Anne M. Molloy ◽  
Barry Shane ◽  
John M. Scott ◽  
...  
Keyword(s):  
Genetic Association ◽  
Association Analysis ◽  
Carbon Metabolism ◽  
Microrna Target ◽  
Genetic Association Analysis ◽  
Target Sites ◽  
One Carbon Metabolism

scholarly journals Genetic Association Analysis of Cell Cycle Regulators Reveals YWHAZ Has Prognostic Significance in Prostate Cancer

2020 ◽  
Vol 17 (2) ◽  
pp. 209-216 ◽  
Author(s):  
CHIA-CHENG YU ◽  
LIH-CHYANG CHEN ◽  
WEN-HSIN LIN ◽  
VICTOR C. LIN ◽  
CHAO-YUAN HUANG ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Cycle ◽  
Genetic Association ◽  
Association Analysis ◽  
Prognostic Significance ◽  
Cell Cycle Regulators ◽  
Genetic Association Analysis
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